The invention relates to a thermal-force coupling fatigue test device and method, belonging to the field of metal material performance test and analysis. The device comprises a tested material test sample, a cold-thermal fatigue system and a stress fatigue system, wherein the test sample comprises a clamping section, a test section and a transition section; the cold-thermal fatigue system comprises a high frequency induction coil, a rotary seal device, a flow pump, a temperature sensor, a heating power supply, a cooling medium pipeline and a control system; and the stress fatigue system mainly comprises a driving rotating fixture, a driven rotating fixture, a transmission gear, a motor and a motor control system. The method comprises the following steps of: connecting and fixing the test sample with the cold-thermal fatigue system and the stress fatigue system, and carrying out cold-thermal fatigue while stress fatigues under different stresses are carried out to obtain a curve which shows variation of stress fatigue life along with cyclic stress; and adjusting parameters of the cold-thermal fatigue, thus influence of cold-thermal fatigue temperature to fatigue limit can be obtained.