The invention provides and discloses a dyeing and finishing process of a PLA fiber / pearl fiber blended fabric.The process includes the first step of singeing, the second step of desizing, the third step of souring and bleaching, the fourth step of whitening, the fifth step of presetting, the six step of mercerizing, the seventh step of primary dyeing, the eighth step of secondary dyeing, the ninth step of soaping, the tenth step of drying, the eleventh step of padding, the twelfth step of drying, the thirteenth step of baking, the fourteenth step of setting, the fifteenth step of calendering and the sixteenth step of rolling.By adding the whitening step before the presetting step, the whiteness and overall performance of the fabric are improved without damaging the fabric, and the stability and effectiveness of dyeing, padding, setting and calendering in the subsequent steps are guaranteed; two types of fiber are dyed according to the difference of dyes suitable for PLA fiber and pearl fiber, and the dyeing effect is further optimized.