Special disease-resisting and rooting nutritious mud for seedling cutting is prepared from following components: 90-110 g of urea, 180-220 g of calcined loess powder, 45-55 g of nitrogenous fertilizer, 8-12 g of magnesium sulfate, 70-90 g of plant ash, 250-350 g of leaf mold, 80-120 g of pit mud, 50-70 g of rooting powder, 35-45 g of neutral detergent, 45-55 g of sea mud, 8-12 g of an erythromycin ointment, 45-55 ml of 1.8% abamectin emulsifiable concentrate, 35-45 g of dry clover leaf powder, 15-25 g of sodium selenite, 8-12 g of saponin, 15-25 g of potassium fulvic acid, 45-55 g of monopotassium phosphate, 45-55 g of algae micropowder, 4-6 g of alanine and 8-12 g of ofloxacin gel. The nutritious mud can promote the germination vitality of plants, rooting is easy, the survival rate is high, the mud has good disease resistance, and diseases and insect pests are reduced for the seedlings; meanwhile, nutrients required for normal growth of the seedlings can be provided, the planting cost is reduced, and the economic benefit is increased.