The invention discloses a moisture-proof mobile substation, include a box body of a substation, an upper protective plate attached to the top of the box body of the substation and a side protective plate attached to the left and right sides of the box body of the substation, A heat insulation and moisture absorption cavity is formed between the side surface of the box body and the side protectiveplate of the transformer substation, A plurality of groups of heat-insulating moisture-absorbing cotton are arranged in the heat-insulating moisture-absorbing cavity, heat insulation and moisture absorption cotton can absorb and insulate certain heat, and is capable of absorbing heat conducted through the side shields, it has good effect of heat insulation and moisture absorption, the normal working condition of the substation box is ensured, A telescopic move wheel is arranged at that low end of the box body of the substation, the movable wheel and its telescopic structure are isolated and protected in a moisture-proof cavity in an internal protective housing, The invention avoids the phenomenon that the external moisture enters the inside of the substation box body from the protruding groove, has good moisture-proof property as a whole, is convenient to move, can change and move the substation box body according to the actual demand, is convenient to move the position of the substation box body in time when the water is swollen, and can cope with the sudden situation.