The invention discloses an efficient full-automatic laser welding system. The system comprises a supporting base, wherein a welding mechanism, a grinding mechanism, a cooling box and a fixing supportframe are arranged on the outer surface of the upper end of the supporting base, a movable cross beam is fixedly connected to the top end of the fixing support frame, a first motor is arranged at oneend of the movable cross beam, a lead screw is fixedly connected to one end of a rotating shaft of the first motor, the lead screw penetrates through the inner part of the movable cross beam, the outer part of the movable cross beam is sleeved with a movable block, the movable block is in threaded connection with the lead screw in the movable cross beam, a movable longitudinal beam is arranged onone side of the movable cross beam, and a second motor is arranged at one end of the movable longitudinal beam. According to the efficient full-automatic laser welding system, feeding, transferring and discharging can be synchronously operated, meanwhile, welding, air cooling and grinding can be synchronously carried out, full-automatic production and machining are achieved, and the production efficiency is effectively improved.