The invention provides a main bearing grease replacement method for a fan driving chain. The method comprises the following steps that old grease in a cavity on the side, close to a gear box, of a bearing seat is cleaned up at first, new grease is poured into the cavity on the side of the gear box, then new grease is poured into the cavity of the bearing seat in a turning state, and the new grease and the old grease in the cavity on the side, far away from the gear box, of the bearing seat are mixed; and meanwhile, most of the new and old mixed grease in the cavity on the side far away from the gear box is washed away through the poured-in new grease, then the new grease is injected again in the turning state, the new grease and the old grease can be evenly mixed and then discharged, then the new grease is injected multiple times, evenly mixed and then discharged, finally, the discharged grease does not change color, and cleaning of the old grease is completed. The discharged old grease needs to be weighed in the whole process, so that it is guaranteed that the total grease injection amount and the total grease discharging amount are almost the same. The grease of a main bearing can be replaced through grease injection and grease discharging methods, damage of a bearing oil film can be reduced to the maximum extent, the lubricating environment of the main bearing is improved, and the service life of the main bearing is prolonged.