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31results about How to "Low measurement disturbance" patented technology
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Wheeled type distance measuring apparatus
InactiveCN101285674AAvoid disturbing influenceLow measurement disturbanceUsing electrical meansForeign matterEngineering
The invention relates to a wheeled range finder, comprising a handle and a hand grip on the handle. The lower part of the handle is fixed with a wheel seat, and a rotatable measuring wheel is arranged on the side of the wheel seat. The range finder is characterized in that: a magnetic steel element is fixed on the side of the measuring wheel; a hall induction sensor matched with the magnetic steel element is fixed inside the wheel seat; an output of the hall induction sensor is connected with a control circuit; an output of the control circuit is connected with a display screen on the hand grip. The range finder matches the magnetic steel element with the hall induction sensor, can avoid the interference and influence from outside weather and foreign matter, and is little in measurement interference and higher in precision. In addition, the range finder automatically subtracts the reversing rotation distance of the measuring wheel from the present distance data, which is more convenient to use, reasonable and practical in integral structure design and easy to assemble and produce.
Owner:宁波蓝达实业有限公司
Soil multiparameter sensing measurement system
InactiveCN102997964ASolve the problem that cannot be measured at the same pointHigh measurement accuracyMaterial analysis by electric/magnetic meansData acquisitionEngineering
The invention discloses a soil multiparameter sensing measurement system which comprises a sensor, a data acquisition processing unit and a power supply part. The sensor comprises a probe circuit, middle stainless steel tubes and peripheral stainless steel tubes, wherein the middle stainless steel tubes and the peripheral stainless steel tubes are fixed through a printed circuit board (PCB). The power supply part is a power supply circuit and comprises a heat source constant flow source and a system voltage stabilization source which provides power for the whole system. The soil multiparameter sensing measurement system can acquire data of multiple parameters of soil simultaneously and effectively solves the problem that simultaneous measurement cannot be achieved in soil physics. Besides, by utilizing a frequency dispersion method to measure soil water content, interference to measurement of the soil water content caused by factors such as the soil temperature and salt content can be effectively reduced, the application range of the sensor is expanded, and measurement accuracy of the soil water content is improved. The head of the sensor adopts the specially-designed PCB, so that connection matching between the probe circuit and a probing needle is effectively achieved, the microwave reflected value is reduced, the measurement accuracy is improved, and maintenance of the sensor and replacement of the probing needle are facilitated.
Owner:NORTHWEST A & F UNIV
Hypersonic wind tunnel double-cover-body static cover throwing back support force measurement test device
PendingCN111122101ARealize synchronous regulationIncrease stiffnessAerodynamic testingMeasurement testClassical mechanics
The invention discloses a hypersonic wind tunnel double-cover-body static cover throwing back support force measurement test device. The device comprises a projectile body model, and two half cover body models, two sets of half cover angle adjusting devices and two sets of Y-direction interstage distance adjusting devices which are symmetrically distributed above and below the projectile body model. According to the hypersonic wind tunnel double-cover-body static cover throwing back support force measurement test device and the Y-direction stage spacing adjustment device, an integrated designis adopted, a semi-cover body balance is arranged in the internal space of the semi-cover angle adjusting device, the supporting and protecting problems of the half-cover balance are solved, the rigidity and strength of the device are improved, supporting components are reduced, static force measurement of separation of the hypersonic wind tunnel double-cover body and the projectile body is achieved, and adjustment of the half-cover angle of the half-cover model and adjustment of the distance between the projectile body model and the half-cover model are achieved.
Owner:中国空气动力研究与发展中心超高速空气动力研究所
VFTO test apparatus for 500-kV GIS basin type insulator
InactiveCN107356823AHigh precisionLow measurement disturbanceElectrostatic field measurementsObservational errorPositive pressure
The application relates to the technical field of insulating material performance testing, in particular to a VFTO test apparatus for a 500-kV GIS basin type insulator. In practical operation, surface charges are accumulated on the surface of the GIS basin insulator to cause distortion of a local electric field, so that the insulator surface flashover under VFTO is caused; and thus the interference on the space electrical field measurement is caused, so that the measurement error is increased. The VFTO test apparatus is composed of an electric field measurement unit, a data processing unit and an energy supply unit. The electric field measurement unit consists of a positive-pressure container module, a high-voltage electrode module, a to-be-tested basin type insulator module and sensor modules; the data processing unit includes a data calculation module and a display module; and the energy supply unit includes a high-voltage power supply module connected to the high-voltage electrode module. The test apparatus has advantages of small measurement interference, small error, and high precision.
Owner:YUNNAN POWER GRID CO LTD ELECTRIC POWER RES INST
Gas concentration detection system based on wavelength modulation spectrum and gas concentration detection method based on wavelength modulation spectrum
PendingCN107478601AImprove inspection accuracyAccurate Alignment of Absorption WavelengthsColor/spectral properties measurementsDistributed feedback laserEngineering
The invention relates to a gas concentration detection system based on a wavelength modulation spectrum. A sine wave signal output end of a first signal generator of the system is connected with a summator; a triangular wave signal output end of a second signal generator is connected with the summator; the signal output end of the summator is connected with a pulse width modulator; the signal output end of the pulse width modulator is connected with a laser drive; the laser drive signal input end of the laser drive is connected with a distribution type feedback laser; the laser signal output end surface of the distribution type feedback laser faces to the laser signal incidence port of a gas concentration detection gas chamber; the signal input end of a laser detector faces to the laser signal outgoing port of the gas concentration detection gas chamber; the laser sensing signal output end of the laser detector is connected with a signal input end of a processor; the cosine wave signal output end of the first signal generator is connected with a locking amplifier; the signal output end of the locking amplifier is connected with the processor; the triangular wave signal output end of the second signal generator is connected with the processor. By adopting the gas concentration detection system, the concentration of gases can be accurately measured.
Owner:JIANGHAN UNIVERSITY
Surface enhanced Raman spectrum detection method for gene based on CRISPR/Cas12a protein
PendingCN113736853AEfficient detectionAccurate detectionMicrobiological testing/measurementMicroorganism based processesDiseaseTernary complex
The invention discloses a surface enhanced Raman spectrum detection method for a gene based on CRISPR / Cas12a protein. Target virus nucleic acid, Cas12a and crRNA are utilized to form a ternary complex, and a substrate (i.e., ssDNA) in a cleavage system is opened. The ssDNA is a bridging complementary sequence of DNA1 and DNA2 on a probe 1 and a probe 2. Whether the probe 1 and the probe 2 are bridged or not can cause change of SERS signals, so that whether a sample to be detected contains target nucleic acid or not can be known. Accurate and rapid detection of viral nucleic acid can be realized by using the specific crRNA. The CRISPR@Cas12a is combined with the SERS technology, so that the biggest advantage is that a tedious modification preparation process is avoided, and the SERS probe can stably exist for a long time. According to the method, the key step of signal amplification occurs on a solution phase of ssDNA instead of an interface of a nano assembly, so that the method is more stable and higher in trans-cutting efficiency, the sensitivity and repeatability of the detection method can be guaranteed, and the method has important significance in early monitoring, diagnosis, prevention and control of diseases.
Owner:JILIN UNIV
Vibration measurement device for laser interference rotor and measurement method thereof
InactiveCN103335704AReduce machining errorsImplementing FM MeasurementsSubsonic/sonic/ultrasonic wave measurementUsing wave/particle radiation meansVibration measurementLaser interference
The invention provides a technical scheme of a vibration measurement device for a laser interference rotor and a measurement method thereof. The scheme can simultaneously detect bending vibration and torsional vibration of a high-speed rotor based on beat frequency generated by laser Doppler effect, realizes frequency modulation measurement of a vibration signal under the condition of not using an expensive frequency shift device, and precisely distinguishes the directions of bending vibration and torsional vibration, has very strong anti-environment disturbance capability, and is low in manufacturing cost. The scheme belongs to non-contact measurement, the motion state of the to-be-measured rotor is free from interference, the accuracy in measurement is high, the response speed is fast, the dynamic range is wide, and the measurement can be performed at a further distance. The processing error of the rotor and measurement interference of torsional vibration and bending vibration from other vibration states are small.
Owner:SOUTHWEAT UNIV OF SCI & TECH
High-throughput screening method for targeted drug
PendingCN113189078AAchieve fishingLow measurement disturbanceRaman scatteringHigh-Throughput Screening MethodsProtein target
The invention discloses a high-throughput screening technology of a targeted drug, which comprises the following steps: respectively coupling a metal nanoparticle probe or a magnetic bead probe to a Raman signal molecule, a target protein or a target protein binding receptor protein, simultaneously adding the substances into a compound to be screened, incubating, finally detecting a Raman signal, and judging whether the compound to be screened is a targeted inhibitor or not, the targeted inhibitor having the characteristic of inhibiting target protein related biological activity. Raman signal detection is applied to the technical field of targeted new drug screening for the first time, and metal nanoparticles and magnetic beads are combined to form a simple and sensitive new drug screening method. Meanwhile, the method is small in measurement interference, small in required sample amount, strong in signal, high in sensitivity and easy and convenient to operate, cleaning is not needed in the whole detection process, and a new strategy is provided for a targeted drug screening approach.
Owner:JILIN UNIV
Method for fishing active small molecules from mixed combination chemical molecule library
ActiveCN113655046AOptimize quantityIncrease the number ofComponent separationRaman scatteringChemical mixturesProtein target
The invention discloses a method for fishing and screening active monomer components or active component groups from a combinatorial chemical mixture library based on surface enhanced Raman spectroscopy combined with high resolution mass spectrometry (HRMS). An active component monomer or an active component group based on target protein is screened out from a small-molecule mixed compound group in a fishing manner by combining SERS and HRMS analysis technologies. The method is small in measurement interference, low in false positive, extremely small in required sample amount, strong in signal, high in sensitivity, simple and convenient to operate, capable of realizing high-throughput screening and reusable in compound library, and provides a new strategy for a targeted drug screening approach.
Owner:JILIN UNIV
Flow induction noise isolating and muffling device
ActiveCN102620104ALow measurement disturbanceReliable sound insulationSubsonic/sonic/ultrasonic wave measurementPipe elementsNoise controlUltrasound attenuation
The invention discloses a flow induction noise isolating and muffling device, relates to the field of noise control, and in particular relates to an isolation device for two flow water noise sources. The flow induction noise isolating and muffling device comprises an inlet pipe (1), an outlet pipe (2), an air exhaust port (3), a pot body (4) and a multipore plate (5). An interference muffling technology, a variable-frequency attenuation muffling technology and a multipore noise absorption technology are comprehensively used, so that mutual interference between the two noise sources is isolated; and aiming at a multi-frequency noise muffling situation, a good noise reduction effect is achieved. The flow induction noise isolating and muffling device is high in muffling and noise isolation performance, is convenient to process and has a small volume.
Owner:JIANGSU UNIV ZHENJIANG RES INST OF FLUID ENG EQUIP TECH
Multichannel synchronous absolute distance measurement method and device based on all-fiber frequency domain interference
The embodiment of the invention provides a multichannel synchronous absolute distance measurement method and device based on all-fiber frequency domain interference, and relates to the technical fieldof absolute distance precision measurement. The method comprises the steps that a broadband light source is divided into n paths of measurement light, and the n paths of measurement light pass through an optical fiber probe and a measurement target and then return to n paths of reference light and corresponding detection light; all the n paths of reference light and the spectrum after the frequency domain interference of the corresponding detection light are integrated, and the light intensity of the light and the spectrum are recorded, wherein Ii(f) is the light intensity after the frequencydomain interference of the n paths of reference light and the corresponding detection light; and segmentation processing is performed on the I(f) to obtain a corresponding power spectrum function Gi(t) so as to obtain an absolute distance between the end surface of the optical fiber probe corresponding to each channel and the surface of a reflector. The absolute distances between the surfaces ofa plurality of measured objects and the light emitting end face of the optical fiber probe can be synchronously measured with high precision, the measurement precision is superior to 5 [mu]m, and themeasurement range can reach 200 mm.
Owner:INST OF FLUID PHYSICS CHINA ACAD OF ENG PHYSICS
A test device and test method for testing the thermal mechanical properties of a safety valve
ActiveCN103852245BAvoid the problem of frequency hoppingAccurate recording of mechanical propertiesMachine part testingSteam pressureData treatment
Owner:EAST CHINA UNIV OF SCI & TECH
Method for measuring human body phase angle
PendingCN112674751ALow costLow measurement disturbanceDiagnostic recording/measuringSensorsComputational physicsHuman body
The invention relates to a method for measuring a body phase angle. The method comprises the following steps: selecting a frequency f1 below 200khz as a first acquisition frequency of body impedance, and acquiring a first body impedance value z1; selecting a frequency f2 above 200khz as a second group of acquisition frequencies of the body impedance, and acquiring a second body impedance value z2; calculating a first estimated value of body capacitance impedance corresponding to the frequency f1, namely subtracting z2 from z1 to acquire zc; repeating the steps S1, S2 and S3, and collecting n groups of body capacitance impedance first estimated values of different persons as a fitting data set; applying a fitting algorithm through the fitting data set, to obtain a k value and a b value in a body capacitive reactance value estimation model ze which is the sum of k zc and b; repeating the steps S1 and S2 to obtain a first estimated value zc of the body capacitive reactance, and applying the body capacitive reactance estimation model to obtaining a second estimated value ze of the body capacitive reactance; and calculating a body phase angle corresponding to the frequency f1 as arctan (ze / z2).
Owner:戴昊霖
A method to fish for active small molecules from a library of mixed combinatorial chemical molecules
ActiveCN113655046BOptimize quantityIncrease the number ofComponent separationRaman scatteringChemical mixturesProtein target
The invention discloses a method for fishing and screening active monomer components or groups of active components from a combinatorial chemical mixture library based on surface-enhanced Raman spectroscopy combined with high-resolution mass spectrometry technology (HRMS), and combining SERS and HRMS analysis technology from small molecule mixed compound groups. Fishing to screen out the active ingredient monomer or active ingredient group based on the target protein. The method has low measurement interference, low false positives, extremely small sample volume, strong signal and high sensitivity, and is easy to operate, which can realize high-throughput screening, and the compound library can be reused, which provides a new strategy for targeted drug screening. .
Owner:JILIN UNIV
Method for measuring primary ray spectrum of X-ray tube
PendingCN114660102AEasy to measureReduced measurement pathMaterial analysis using wave/particle radiationCalibration coefficientRay
The invention discloses a method for measuring a primary ray spectrum of an X-ray tube. The method comprises the following steps: placing the X-ray tube, a first aluminum plate and a detector in sequence; after the X-ray tube is arranged, a spectrogram P1 is obtained through a detector; taking away the first aluminum plate, replacing the first aluminum plate with a second aluminum plate with the thickness of D2, and retesting to obtain a spectrogram P2; according to the energy calibration coefficient of the detector, the channel numbers of the spectrogram P1 and the spectrogram P2 are converted into energy values, and a spectrogram P3 is obtained; obtaining a spectrogram P4 of the rays emitted by the X-ray tube before being absorbed by the first aluminum plate or the second aluminum plate according to the absorption of the rays by the first aluminum plate and the second aluminum plate; and according to the beryllium window of the X-ray tube and the absorption of the air to the rays, obtaining a spectrogram P5 of the rays emitted by the X-ray tube before the rays are absorbed by the beryllium window and the air. According to the measurement method, the aluminum plate is adopted as a ray attenuation medium of the X-ray tube, the measurement path is short, interference is reduced in a differential mode, the measurement accuracy is high, and use is convenient.
Owner:ANHUI WAYEE SCI & TECH CO LTD
A laser interference rotor vibration measuring device and its measuring method
InactiveCN103335704BReduce machining errorsImplementing FM MeasurementsSubsonic/sonic/ultrasonic wave measurementUsing wave/particle radiation meansVibratory signalTorsional vibration
The invention provides a technical scheme of a vibration measurement device for a laser interference rotor and a measurement method thereof. The scheme can simultaneously detect bending vibration and torsional vibration of a high-speed rotor based on beat frequency generated by laser Doppler effect, realizes frequency modulation measurement of a vibration signal under the condition of not using an expensive frequency shift device, and precisely distinguishes the directions of bending vibration and torsional vibration, has very strong anti-environment disturbance capability, and is low in manufacturing cost. The scheme belongs to non-contact measurement, the motion state of the to-be-measured rotor is free from interference, the accuracy in measurement is high, the response speed is fast, the dynamic range is wide, and the measurement can be performed at a further distance. The processing error of the rotor and measurement interference of torsional vibration and bending vibration from other vibration states are small.
Owner:SOUTHWEAT UNIV OF SCI & TECH
Carbon sink fishery monitoring device
ActiveCN103616480BNovel structureLow measurement disturbanceWithdrawing sample devicesCarbon sinkTest requirements
The invention discloses a carbon sink fishery monitoring device. The carbon sink fishery monitoring device comprises an inverted cover body with a downward opening, wherein a carbon dioxide detection and collection assembly which can be used for detecting the concentration of carbon dioxide inside and outside the cover body is arranged at the upper part of the side surface of the cover body in a penetrating manner; an air charging and discharging device which can be used for charging air into the inner side of the cover body and discharging the air from the cover body is arranged on the cover body. Air above a tested water surface is isolated from the outside through the inverted cover body. The internal air of the cover body is extracted by the carbon dioxide detection and collection assembly in different time periods according to test requirements for carbon dioxide concentration detection, and is sampled and stored for further analysis. Therefore, the carbon sink fishery monitoring device has the advantages of novel structure and small measurement interference, has a repeated sampling function, and can automatically reset a test environment.
Owner:ZHEJIANG OCEAN UNIV
Weight gravity center measuring device
PendingCN114812935ALow measurement disturbanceHigh precisionStatic/dynamic balance measurementSpecial purpose weighing apparatusUncrewed vehicleEngineering
Owner:CHENGDU AIRCRAFT INDUSTRY GROUP
Soil multiparameter sensing measurement system
InactiveCN102997964BSolve the problem that cannot be measured at the same pointHigh measurement accuracyMaterial analysis by electric/magnetic meansData acquisitionEngineering
Owner:NORTHWEST A & F UNIV
Oil film drifting simulation device
The invention provides an oil film drifting simulation device. The oil film drifting simulation device comprises a central assembly, four side assemblies arranged on the outer side of the central assembly and four corner assemblies arranged on the outer side of the central assembly. Each of the central assembly, the side assemblies and the corner assemblies comprises a main body structure. Each main body structure comprises an assembly chassis, an assembly panel and an assembly cover plate. #-shaped storage grids are arranged in an inner cavity of each assembly, and the #-shaped storage gridsdivide the concave part into nine compartments. According to the oil film drifting simulation device, the limitation that existing oil spill simulation can only depend on numerical simulation or watertank simulation is overcome, and an analysis result which is more suitable for the actual environment is provided for oil spill environment influence evaluation.
Owner:SHANGHAI INVESTIGATION DESIGN & RES INST +2
A ferromagnetic powder low-pass filter and packaging method
ActiveCN111540984BReduce dosageLine lengthWaveguide type devicesLow-pass filterStructural engineering
The invention discloses a ferromagnetic powder low-pass filter and a packaging method, and relates to the technical field of filters. The ferromagnetic powder low-pass filter comprises a shell with openings in the upper end and the lower end, an insulating rod, a wire coil and two packaging connectors. The wire coil is spirally wound on the insulating rod; the two ends of the wire coil protrude out of the upper surface and the lower surface of the insulating rod respectively. The wire coil comprises a first winding section and a second winding section which are connected with each other; the winding directions of the first winding section and the second winding section are opposite, the insulating rod and the wire coil are both arranged in the shell, the insulating rod is arranged in the middle of the shell, the two ends of the shell are each provided with a packaging connector, the two ends of the wire coil are fixedly connected with the two packaging connectors respectively, and theshell is filled with ferromagnetic powder. According to the ferromagnetic powder low-pass filter and the packaging method provided by the invention, the size of the filter is reduced while the performance of the filter is improved, the refrigeration cost is reduced, and the measurement interference in a superconducting device is reduced.
Owner:NANKAI UNIV
PMSM (permanent magnet synchronous motor) degradation experiment device in underground environment and motor service life prediction method
PendingCN114676643ALow measurement disturbanceImprove accuracy and trustworthinessDesign optimisation/simulationAutomotive engineeringOil field
The invention belongs to the technical field of oil field drilling, and discloses a PMSM degradation experiment device in an underground environment and a motor service life prediction method. The method for predicting the residual life of the motor in the underground environment comprises the following steps of: acquiring a measurement signal of a permanent magnet synchronous motor by using a sensor, performing spectral entropy analysis on a stator three-phase current signal of the permanent magnet synchronous motor, and extracting a spectrum complexity change condition of the stator three-phase current signal in a degradation process; wavelet time-frequency band energy conversion is carried out on the vibration signals, and energy changes of the vibration signals in the degradation process are extracted; the collected temperature, sound wave, torque and rotating speed, the extracted stator three-phase current signal and the extracted vibration signal are divided into a training set, a test set and a verification set, and the data sets are transmitted to a network to train the network. According to the method, the real-time residual service life prediction of the permanent magnet synchronous motor of the underground drilling communication tool can be realized, and the operation reliability and the working safety of an underground system are improved.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Power station water vapor multi-parameter cooperative measurement system and measurement method
PendingCN114839227AGuaranteed safe operationImprove measurement accuracyPreparing sample for investigationMaterial resistancePower stationWater vapor
The invention belongs to the field of power station water vapor monitoring, and relates to a power station water vapor multi-parameter collaborative measurement system and method, the measurement system comprises a water sample inlet, a water sample outlet, a first conductivity sensor, a cation removal device, a second conductivity sensor, a desalting device, a membrane exchange device and a third conductivity sensor; the water sample inlet is communicated with the cation removal device through the first conductivity sensor; the cation removal device is respectively communicated with the second conductivity sensor and the desalting device; the second conductivity sensor and the desalting device are connected to the membrane exchange device; the membrane exchange device is communicated with the water sample outlet; the outlet of the membrane exchange device is communicated with the water sample outlet through a third conductivity sensor. The invention provides the power station water vapor multi-parameter cooperative measurement system and the measurement method which are accurate in measurement result and timely in measurement process feedback.
Owner:浙江西热利华智能传感技术有限公司
A sound insulation device for flow-induced noise
ActiveCN102620104BLow measurement disturbanceReliable sound insulationSubsonic/sonic/ultrasonic wave measurementPipe elementsNoise controlUltrasound attenuation
The invention discloses a flow induction noise isolating and muffling device, relates to the field of noise control, and in particular relates to an isolation device for two flow water noise sources. The flow induction noise isolating and muffling device comprises an inlet pipe (1), an outlet pipe (2), an air exhaust port (3), a pot body (4) and a multipore plate (5). An interference muffling technology, a variable-frequency attenuation muffling technology and a multipore noise absorption technology are comprehensively used, so that mutual interference between the two noise sources is isolated; and aiming at a multi-frequency noise muffling situation, a good noise reduction effect is achieved. The flow induction noise isolating and muffling device is high in muffling and noise isolation performance, is convenient to process and has a small volume.
Owner:JIANGSU UNIV ZHENJIANG RES INST OF FLUID ENG EQUIP TECH
Sea Area Carbon Sequestration Wireless Monitoring Buoy
The invention discloses a wireless sea-area carbon sequestration value monitoring buoy. The wireless sea-area carbon sequestration value monitoring buoy comprises a cover body arranged in an inverted mode, wherein the cover body is provided with an opening facing downwards. A carbon dioxide detection and collecting assembly capable of detecting the carbon dioxide concentration of the interior of the cover body and the carbon dioxide concentration of the exterior of the cover body penetrates through the upper portion of the lateral side of the cover body; the cover body is further provided with an air inflow and outflow device capable of conveying air into the inner side of the cover body and discharging the air out of the inner side of the cover body. Air above a water surface to be tested is isolated from the outside by the cover body arranged in the inverted mode. The air of the inner side of the cover body can be pumped at intervals by the carbon dioxide detection and collecting assembly according to testing requirements so that carbon dioxide concentration detection can be carried out, and the air is sampled and stored for further analysis. In this way, the wireless sea-area carbon sequestration value monitoring buoy has the advantages of being novel in structure, small in measurement interference and capable of sampling the air several times and automatically resetting the testing environment.
Owner:ZHEJIANG OCEAN UNIV
DNA coding compound library drug molecule fishing method
ActiveCN113403690AAchieve fishingLow costLibrary screeningProtein nucleotide librariesProtein targetMedication information
A metal nano particle probe is coupled with a target protein or a target protein binding receptor protein, and then is added into a DNA coding compound library prepared in advance for incubation, molecular fishing is carried out, and PCR amplification and DNA sequencing are performed to obtain targeted drug information. Then a metal nano particle probe and a magnetic bead probe are respectively prepared and coupled with a Raman signal molecule, then the metal nano particle probe or the magnetic bead probe is coupled with a target protein or a target protein binding receptor protein and is added into a targeted drug obtained by screening to detect a Raman signal, whether the compound to be screened is a targeted inhibitor or not is judged, and the structure of the screened compound is obtained through PCR amplification and DNA sequencing. According to the invention, molecular fishing and a DNA coding compound library are combined for the first time, drug screening is carried out on a protein interaction level, and a simple and sensitive new drug screening method is formed by combining a surface enhanced Raman scattering spectrum.
Owner:JILIN UNIV
Oil film drift simulator
ActiveCN111239003BHave flat characteristicsPrevent side pushingDiffusion analysisOil spillPetroleum engineering
Owner:SHANGHAI INVESTIGATION DESIGN & RES INST +2
A DNA-encoded compound library drug molecule fishing method
ActiveCN113403690BAchieve fishingLow costLibrary screeningProtein nucleotide librariesProtein targetMedication information
In the present invention, the metal nanoparticle probe is coupled with the target protein or the target protein-binding receptor protein, and is added to a pre-prepared DNA-encoded compound library for incubation to carry out molecular fishing, and targeted drug information is obtained through PCR amplification and DNA sequencing. Then, metal nanoparticle probes and magnetic bead probes were prepared and coupled with Raman signal molecules, respectively, and the metal nanoparticle probes or magnetic bead probes were respectively coupled with target proteins or target protein-binding receptor proteins, and added The Raman signal is detected in the targeted drug obtained by screening to determine whether the compound to be screened is a targeting inhibitor, and the structure of the screened compound is obtained by PCR amplification and DNA sequencing. The present invention combines molecular fishing with a DNA-encoded compound library for the first time, performs drug screening at the protein interaction level, and combines surface-enhanced Raman scattering spectroscopy to form a simple and sensitive new drug screening method.
Owner:JILIN UNIV
An inertial measurement device and an unmanned aerial vehicle
ActiveCN106871895BHigh degree of integrationImprove accuracyNavigation by speed/acceleration measurementsRemote controlled aircraftEngineeringGas pressure transducer
Owner:SHANGHAI TOPXGUN ROBOT CO LTD
Electric energy metering device
InactiveCN103063912ASave wiring spaceImprove accuracyTime integral measurementOvervoltageTransformer
Disclosed is an electric energy metering device. A processor and a control unit connected with the processor are arranged on a machine cabinet. A voltage transformer is arranged above the control unit on the machine cabinet. A voltage input end of the control unit is connected with a voltage binding post arranged on the machine cabinet. The voltage binding post is connected with a secondary winding of the voltage transformer. The voltage transformer is connected with a voltage wire inlet terminal arranged on the machine cabinet. The processor, the control unit and the voltage transformer are installed in the machine cabinet, the voltage transformer is arranged above the control unit, and high voltage passes through the voltage transformer through the voltage wire inlet terminal, and then is input to the control unit through the voltage binding post. The whole distribution is convenient for wire distribution and wire connection, current wire distribution space is compressed, and meanwhile metering interference is reduced, and accuracy of detected data is improved.
Owner:DAZHOU POWER BUREAU SICHUAN ELECTRIC POWER +1
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