The invention relates to the field of clinker cooling, in particular to a cable of a cooling cement clinker grate cooler and a cold-proof and wear-resistant cable of a grate cooler. The cold-proof and wear-resistant cable of the grate cooler comprises two copper alloy wire cores, an insulation layer, an outermost wear-resistant layer, a cold-proof shielding layer, a fireproof layer, a winding layer, a filling layer and a central isolation layer, wherein the outermost wear-resistant layer comprises polyvinylchloride resin, 2,4-dihydroxy benzophenone, carbon black, a stabilizer, an anti-oxygen agent and a plasticizer, and the cold-proof shielding layer comprises a PET resin layer and ITO nanoparticles dispersed in the PET resin layer. By the cold-proof and wear-resistant cable, the weather resistance, the aging resistance and the wear resistance can be improved, the cold-proof and wear-resistant cable has a heat absorption and cold resistant effect, the effect of shielding electron radiation is simultaneously developed, the cable manufacturing cost can be further reduced, the cable production and preparation time is greatly reduced, favorable adhesivity among layers is ensured, and the dead weight of the cable also can be reduced.