The invention discloses a pneumatic main cut-off change-over valve. The valve comprises a base, an air cylinder, an electromagnetic valve and a change-over valve body, the change-over valve body comprises a change-over valve main body, a top plate and a bottom plate, a main air inlet hole is formed in the top plate, an exhaust hole is formed in the side face of the change-over valve main body, and an electromagnetic valve air inlet, an electromagnetic valve air outlet and an air cylinder air inlet are formed in the change-over valve main body. A lifting valve, a valve rod, a spring, a sealing body and a change-over valve piston are arranged in the change-over valve body. The change-over valve body is assembled in a vacuum circuit breaker base and between the electromagnetic valve and a main air cylinder, the change-over valve body effectively connects a gas circuit between a circuit breaker electromagnetic valve and the main air cylinder, the valve between the electromagnetic valve and the change-over valve body is controlled through external power supply and power failure, and switching of the gas circuit in the change-over valve body is achieved. Therefore, air intake and air exhaust of high-pressure air in the main air cylinder are achieved, and closing and breaking operations of the circuit breaker are achieved. The change-over valve is simple and compact in overall structure, high in reliability and capable of being widely applied.