The invention relates to a loading and unloading system for a 3D hot bending machine. The loading and unloading system comprises a machine frame, and a 2D glass feeding assembly, a 2D glass reclaiming manipulator, a 2D glass positioning platform, a 2D glass loading manipulator, a mould placing platform, a mould handling manipulator, an upper mould handling manipulator, a 3D glass unloading manipulator, a 3D glass positioning platform, a 3D glass plug-in manipulator and a 3D glass storage assembly which are arranged on the machine frame, wherein the mould handling manipulator is butt-jointed with the 3D hot bending machine and the mould placing platform, the upper mould handling manipulator is butt-jointed with the mould placing platform, the 2D glass reclaiming manipulator is butt-jointed with the 2D glass feeding assembly and the 2D glass positioning platform, the 2D glass loading manipulator is butt-jointed with the 2D glass positioning platform and the mould placing platform, the 3D glass unloading manipulator is butt-jointed with the mould placing platform and the 3D glass positioning platform, and the 3D glass plug-in manipulator is butt-jointed with the 3D glass positioning platform and the 3D glass storage assembly. The loading and unloading system provided by the invention can be combined with the 3D hot bending machine to form an automated assembly line.