110 results about "Molecule formation" patented technology

Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

An electrostrictive graft elastomer has a backbone molecule which is a non-crystallizable, flexible macromolecular chain and a grafted polymer forming polar graft moieties with backbone molecules. The polar graft moieties have been rotated by an applied electric field, e.g., into substantial polar alignment. The rotation is sustained until the electric field is removed. In another embodiment, a process for producing strain in an elastomer includes: (a) providing a graft elastomer having a backbone molecule which is a non-crystallizable, flexible macromolecular chain and a grafted polymer forming polar graft moieties with backbone molecules; and (b) applying an electric field to the graft elastomer to rotate the polar graft moieties, e.g., into substantial polar alignment.

The invention discloses a test strip for detecting aflatoxin B1 or M1 by utilizing an aptamer. The test strip for detecting the aflatoxin B1 or M1 by utilizing the aptamer, provided by the invention, comprises a sample absorption pad, a marker pad, a reaction film and a water absorption pad, wherein the marker pad is coated with a detection probe; the detection probe is an aflatoxin B1 aptamer marked by fluorescein; the nucleotide sequence of the aflatoxin B1 aptamer is sequence 1; the reaction film comprises a detection region and a quality control region; the detection region is coated with a conjugate formed by an aflatoxin B1 hapten and a carrier protein; and the quality control region is coated with a quality control probe, and the quality control probe is a conjugate formed by avidin conjugation probe marked aflatoxin B1 complementary single strand DNA (Deoxyribose Nucleic Acid)) molecules. The test strip for detecting the aflatoxin B1 or M1, provided by the invention, has the advantages of high sensitivity, accuracy in quantifying, strong specificity, simplicity and convenience, and short detection time.

The present disclosure relates generally to a mucoadhesive nanoparticle delivery system. The nanoparticles are formed from amphiphilic macromolecules conjugated to a mucosal targeting moiety in such a manner that the surface of the nanoparticle is coated with the targeting moiety. The surface density of the targeting moiety can be tuned for adjustable targeting of the nanoparticles to a mucosal site without substantially compromising the stability of the particles. The particles were found to have high loading efficiency and sustained release properties at the mucosal site. The present disclosure also relates to polymers and macromolecules useful in the preparation of the mucoadhesive nanoparticles, as well as compositions, methods, commercial packages, kits and uses related thereto.

The invention relates to a composite material constructed by a molecular engram polymer and a fluorescence conjugated polymer and preparation and application thereof. The invention is characterized in the composite material consists of the fluorescence conjugated polymer, a connection unit and the molecular engram polymer, wherein the connection unit is used for the covalent connection between the side bond of the fluorescence conjugated polymer and the molecular engram polymer, meanwhile, the connection unit and the molecular engram polymer are in the covalent connection. The preparation process comprises the following steps: a functional monomer which can form the molecular engram polymer is introduced to the side chain of the fluorescence conjugated polymer through the covalent bond; and by taking various biological or/and chemical matter molecules as a template and adding a cross linking agent and an initiator, the polymerization reaction is initiated under the condition of heating or illumination, and a template molecule is removed by extraction, and the molecular engram- fluorescence conjugated polymer composite material which can detect various biological and chemical matter molecules simultaneously is obtained. The composite material can be used as a sensing material which can detect various biological and chemical matters simultaneously.

A preparation method of Fe3O4@PEG@SiO2 artificial antibody for detecting thifensulfuron methyl comprises modifying the surface of Fe3O4 magnetic nanoparticles with polyethylene glycol 2000, coating the surface with SiO2 shell layer to form a core-shell-shell structure, diluting marker molecules in the SiO2 shell layer to form specific recognition site holes complementary with marker molecular structure, size and functionality so as to arrive at molecular selective recognition and detection for target analyses. The preparation method of the artificial antibody comprises the steps of first, preparing Fe3O4 magnetic nanoparticles, and modifying their surface with polyethylene glycol; second, adding the target molecule thifensulfuron methyl, a crosslinking agent and a catalyst, and hydrolyzing to obtain Fe3O4@PEG@SiO2 particles with surface-marked thifensulfuron methyl; third, diluting template molecule with a mixed solution of acetic acid and acetone having a volume ratio of 1:4 to obtain the Fe3O4@PEG@SiO2 artificial antibody with selective recognition marker molecules, the antibody having maximum saturated binding capacity of 41.28 mg/g for thifensulfuron methyl, the absorption rate reaches 0.45 mg/g.min within first 30 min which is 5.34 times and 3.46 times that of a non-marking method.

Base materials for tissue regeneration which enable the tissue regeneration, have mechanical properties needed in the tissue regeneration and can disappear via degradation in vivo after the completion of the tissue regeneration; and implantable materials with the use of the same. The above-described base materials for tissue regeneration comprise polyrotaxane, wherein biocompatible groups having bulky substituents have been introduced via hydrolyzable bond into both ends of a linear molecule penetrating plural cyclic molecules, or a polyrotaxane hydrogel having a network structure formed by crosslinking the cyclic molecules to each other, the biocompatible groups to each other, or the cyclic molecules to the biocompatible groups in each polyrotaxane molecule.

A gas cell to be filled with alkali metal atoms includes wall surfaces formed using a compound having polar groups or a material containing the compound, a first coating layer as a coating layer that coats the inner walls, formed using first molecules having functional groups to be chemically bonded to the polar groups and non-polar groups, and a second coating layer formed using non-polar second molecules on the first coating layer.

The invention relates to an electro-polymerizable chemically-modified electrode organic material and application of the electrode organic material in ultra-trace TNT (Trinitrotoluene) detection and belongs to the field of electrochemical sensing technologies. The structural formula of the organic material is shown in the specification, wherein the molecular main chain skeleton consists of an A and two side units B. The A can be pyrene, naphthalene, anthracene, an anthracene derivative, phenanthrene, dibenzo-quinoxaline or the like; each B can be benzene, biphenyl, phenylene vinylene, fluorene or the like; each unit C is an electro-active unit and can be furan, pyrrole, thiophene, carbazole, diphenylamine, triphenylamine or the like. A connecting chain R for the molecular main chain skeleton and electrochemically-polymerized groups can be an alkyl chain, alkoxy chain or oxy chain. Carbazolyl groups can be subjected to crosslinking during electrochemical polymerization, and molecules can form spherical micro-nano structures due to crosslinking, so that on one hand, the contact specific surface area between the molecules of the organic material and TNT molecules is increased, on the other hand, due to pore structures formed among the micro-nano structures, TNT molecule diffusion paths are increased, and electrical signal response is enhanced.

A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety that directs the compound to a site a marker substance. The compound is chelated to a medically active material that generates a signal for diagnostic imaging or produces a therapeutic effect at the site of the marker substance. A method for detecting, diagnosing, and/or treating a disease that produces the marker substance uses a conjugate comprising the multifunctional cross-bridged tetraaza macrocyclic compound.

The invention belongs to the field of preparation of ionic hydrogen bond organic framework materials, and particularly discloses an ionic hydrogen bond organic framework material with proton conduction performance, the chemical formula of the ionic hydrogen bond organic framework material is {TPE-SO3H. 2 (DBD). 2 (DMF). 4 (H2O)} n, n is a positive integer, TPE-SO3H is 1, 1, 2, 2-tetrasulfonic acidphenyl ethylene, DBD is (C5NH4NH2) 22+, and DMF is N, N '-dimethylformamide. The structural unit belongs to a triclinic system, the space group is P-1, the molecular formula is C52H62N10O18S4, the cell parameters are as follows: alpha = 102.789 degrees, beta = 99.968 degrees and gamma = 112.169 degrees, each repetitive unit comprises four water molecules and two DMF molecules, two DBD molecules and one TPE-SO3H molecule, and amino groups on the DBD molecules and sulfonate groups on the TPE-SO3H molecule form a one-dimensional hydrogen bond network with water molecules. The material has good thermal stability, and has good performance for proton transportation. The invention discloses the preparation method of the material, the synthetic raw materials are easy to obtain, and the preparation process is simple. The ionic hydrogen bond organic framework material disclosed by the invention can be used as a proton conducting material and has a very good application prospect.

On the quartz wafer a thin layer of gold film or silver film is plated, then the quartz wafer is vibrated to selectively adsorb DNA, and the hybridization of DNA molecule can be used to combine into double-chain DNA, then the nano microsphere of medicine of biological reagent which is marked to make selective action with double-chain DNA can be used to confirm target double-chain DNA molecule formation and make mass amplification so as to detect ultratrace target DNA. Its selectivity is strong and its sensitiveness is high.

A polyester resin toner binder which gives a toner with good anti-blocking property at high temperature and high humidity and good low-temperature fixing ability. The present invention is directed to a toner binder for developing electrostatic charge images, which binder comprises a condensation-polymerization polyester resin, the polyester resin being a product formed in the presence of a catalyst (a) represented by the following general formula (I):

Ti(—X)m(—OR)n  (I)

wherein R is H or a hydrocarbon group having from 1 to 24 carbon atoms which may contain from 1 to 3 ether bonds and/or from 1 to 2 hydroxyl groups; X is a residue formed by removing H of one carboxyl group from an aromatic mono- or polycarboxylic acid, provided that in the case of a polycarboxylic acid, a carboxyl group other than said one carboxyl group may intra molecularly polycondense with an OR group in the same molecule to form a ring structure or may form a structure where it has polycondensed intermolecularly with an OR group in another molecule; m=1 to 3, n=1 to 3, and the sum of m and n is 4.

The invention provides a preparation method of a biological binary composite adsorbent in a glycerol triacetate refinement process, and aims at overcoming the deficiencies of relatively poor selectivity, easiness in saturation, non-ideal subsequent refinement effect, high use cost and the like due to adoption of single active carbon as an adsorbent for removing residual organic matters in a subsequent process of glycerol triacetate in the prior art. According to the method, the surface of active carbon is grafted and coated with cyclodextrin, so that the content of oxygen-containing groups on the surface of active carbon is increased, the characteristics of active carbon are added, and active carbon can form an inclusion compound and a molecular assembly system together with a large quantity of organic and inorganic molecules under the Van der Waals' force, the hydrophobic interaction force, the effect of matching between molecules of subjective and objective bodies and the like; the enveloping effect of selective combination is commonly known as the molecular identification, and finally a high-efficiency elution effect is achieved.

Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus,

In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22.

Particularly, an asymmetric bipolar lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n is an integer of 18 to 22, both of Z₁ and Z₂ are single bonds, Y is Gly, m(s) is the same or different integer of 3 to 6, X is OH, and R is a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic acid based asymmetric nanotube by single component self-assembly or binary self-assembly.

The invention relates to a short peptide derived from a tumor antigen SAGE1, a complex of the short peptide and an MHC molecule, and uses of the short peptide and the complex. Meanwhile, the inventionfurther relates to molecules bound with the short peptide or the complex and uses of the molecules.

A simple, highly efficient, and environmentally friendly method of immobilizing macromolecules, particularly the biomolecules, to a solid carrier and thus forming a bioreactor, including the following steps: (1) providing the biomolecule and a leading molecule, and linking the biomolecule and the leading molecule by microwave to form an adsorbent; (2) providing a porous support material, and mixing the porous support material and the adsorbent to form a mixture; (3) treating the mixture by a vortex process such that the adsorbent being adsorbed and immobilized on the porous support material to form a bioreactor for biological reactions and biocatalysis; and the bioreactor can be further used for constructing a biological reaction system via incorporating a buffer solution and a ligand.

The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.

It is an object of the present invention to provide a practically applicable substrate for blood treatment for specifically capturing a target substance such as a cell directly from the whole blood, and an inexpensively and industrially applicable substrate for biological fluid treatment which is capable of separating a target substance directly from a biological fluid. The present invention provides a substrate for biological fluid treatment in which a recognition molecule having a selective binding property for a target substance is covalently immobilized on a surface of the substrate, wherein the recognition molecule is a linear molecule comprising a ligand moiety and an association domain, and at least four or more recognition molecules form an assembly structure.

The invention relates to a compound and application thereof, wherein the compound has a structure as shown in formula I. According to the invention, compared with long-chain alkyl, isopropyl, tert-butyl, isobutyl, cyclopentyl, cyclohexyl or cycloheptyl introduced in the structure can improve the structural stability of the compound, and the groups have small influence on spatial arrangement of molecules, so that the molecules can be tightly stacked in spatial arrangement, and the molecules can form a uniform and compact film so as to achieve high transmission efficiency of carriers in the molecules; the chemical property of saturated alkane is stable, and compared with an aromatic ring with a conjugated structure, a chemical bond retains certain flexibility, so that the crystallization phenomenon of molecules in the device preparation process can be avoided; and C10-C30 aryl or heteroaryl is introduced to the ortho-position of N in arylamine, and the groups are matched, so that the compound disclosed by the invention has excellent chemical stability and charge transfer performance, the starting voltage of a device can be reduced, the current efficiency can be improved, and the service life can be prolonged.