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114 results about "Molecule formation" patented technology

Molecules are formed by combination of atoms or ions by chemically bonding to each other or held by attractive forces due to the charges. A molecule is smallest particle of an element or compound, which is capable of independent existence. If the molecule is made up of atoms of the same element it is said to be homo-atomic.

Oligomers

Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.
Owner:ROYAL HOLLOWAY & BEDFORD NEW COLLEGE

Method of electrically detecting a biological analyte molecule

The invention provides a method of electrically detecting a biological analyte molecule by means of a pair of electrodes. The electrodes are arranged at a distance from one another within a sensing zone. A capture molecule, which has an affinity to the analyte molecule and which is capable of forming a complex with the analyte molecule, is immobilised on an immobilisation unit. The immobilisation unit is contacted with a solution suspected to comprise the analyte molecule. The analyte molecule is allowed to form a complex with the capture molecule. The invention also provides a probe defined by a nanoparticulate tag that comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule. In the method of the invention the electrically conducting nanoparticulate tag is added. Thereby the electrically conducting nanoparticulate tag is allowed to associate to the complex formed between the capture molecule and the analyte molecule. The presence of the analyte molecule is determined based on an electrical characteristic, influenced by the electrically conducting nanoparticulate tag, of a region in the sensing zone.
Owner:AGENCY FOR SCI TECH & RES

Electrostrictive graft elastomers

An electrostrictive graft elastomer has a backbone molecule which is a non-crystallizable, flexible macromolecular chain and a grafted polymer forming polar graft moieties with backbone molecules. The polar graft moieties have been rotated by an applied electric field, e.g., into substantial polar alignment. The rotation is sustained until the electric field is removed. In another embodiment, a process for producing strain in an elastomer includes: (a) providing a graft elastomer having a backbone molecule which is a non-crystallizable, flexible macromolecular chain and a grafted polymer forming polar graft moieties with backbone molecules; and (b) applying an electric field to the graft elastomer to rotate the polar graft moieties, e.g., into substantial polar alignment.
Owner:NASA

Organic thin-film transistor

The present invention relates to organic thin-film transistors using an organic compound in the semiconductor layer thereof. The organic semiconductor layer is made by means of Cascade Crystallization Process. Said layer is characterized by a globally ordered crystalline structure with intermolecular spacing of 3.4±0.3 Å in the direction of one crystal axis. This layer is formed by rodlike supramolecules comprising at least one polycyclic organic compound with conjugated π-system and has electron-hole type of conductivity.
Owner:NITTO DENKO CORP

Test strip for detecting aflatoxin B1 or M1 by utilizing aptamer

ActiveCN105784990AHigh sensitivityWith precise quantitativeMaterial analysisAptamerCarrier protein
The invention discloses a test strip for detecting aflatoxin B1 or M1 by utilizing an aptamer. The test strip for detecting the aflatoxin B1 or M1 by utilizing the aptamer, provided by the invention, comprises a sample absorption pad, a marker pad, a reaction film and a water absorption pad, wherein the marker pad is coated with a detection probe; the detection probe is an aflatoxin B1 aptamer marked by fluorescein; the nucleotide sequence of the aflatoxin B1 aptamer is sequence 1; the reaction film comprises a detection region and a quality control region; the detection region is coated with a conjugate formed by an aflatoxin B1 hapten and a carrier protein; and the quality control region is coated with a quality control probe, and the quality control probe is a conjugate formed by avidin conjugation probe marked aflatoxin B1 complementary single strand DNA (Deoxyribose Nucleic Acid)) molecules. The test strip for detecting the aflatoxin B1 or M1, provided by the invention, has the advantages of high sensitivity, accuracy in quantifying, strong specificity, simplicity and convenience, and short detection time.
Owner:INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS

Mucoadhesive nanoparticle delivery system

The present disclosure relates generally to a mucoadhesive nanoparticle delivery system. The nanoparticles are formed from amphiphilic macromolecules conjugated to a mucosal targeting moiety in such a manner that the surface of the nanoparticle is coated with the targeting moiety. The surface density of the targeting moiety can be tuned for adjustable targeting of the nanoparticles to a mucosal site without substantially compromising the stability of the particles. The particles were found to have high loading efficiency and sustained release properties at the mucosal site. The present disclosure also relates to polymers and macromolecules useful in the preparation of the mucoadhesive nanoparticles, as well as compositions, methods, commercial packages, kits and uses related thereto.
Owner:UNIVERSITY OF WATERLOO

Compound material constructed by molecular engram and fluorescent conjugated polymer, preparation and application

The invention relates to a composite material constructed by a molecular engram polymer and a fluorescence conjugated polymer and preparation and application thereof. The invention is characterized in the composite material consists of the fluorescence conjugated polymer, a connection unit and the molecular engram polymer, wherein the connection unit is used for the covalent connection between the side bond of the fluorescence conjugated polymer and the molecular engram polymer, meanwhile, the connection unit and the molecular engram polymer are in the covalent connection. The preparation process comprises the following steps: a functional monomer which can form the molecular engram polymer is introduced to the side chain of the fluorescence conjugated polymer through the covalent bond; and by taking various biological or / and chemical matter molecules as a template and adding a cross linking agent and an initiator, the polymerization reaction is initiated under the condition of heating or illumination, and a template molecule is removed by extraction, and the molecular engram- fluorescence conjugated polymer composite material which can detect various biological and chemical matter molecules simultaneously is obtained. The composite material can be used as a sensing material which can detect various biological and chemical matters simultaneously.
Owner:浙江同创海诚科技有限公司

Temperature sensitive control of liposome-cell adhesion

The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises poloxamer molecules and liposomes encapsulating one or more delivery agents. At above the critical micellar temperature of the poloxamer, a fraction of the poloxamer molecules form micelles and another fraction becomes incorporated into the liposome surface, thereby inhibiting their adhesion to cells. At a temperature below the critical micellar temperature, the poloxamer molecules dissociate into monomers allowing the liposomes to adhere to adjacent cells and effecting retention of the liposomes in the surrounding tissue. A method is provided for delivery of agents to target site comprising administering the composition to an individual and cooling the target site to cause retention of the liposomes at or near the target site.
Owner:HEALTH RES INC

Preparation method of Fe3O4@PEG@SiO2 artificial antibody for detecting thifensulfuron methyl

A preparation method of Fe3O4@PEG@SiO2 artificial antibody for detecting thifensulfuron methyl comprises modifying the surface of Fe3O4 magnetic nanoparticles with polyethylene glycol 2000, coating the surface with SiO2 shell layer to form a core-shell-shell structure, diluting marker molecules in the SiO2 shell layer to form specific recognition site holes complementary with marker molecular structure, size and functionality so as to arrive at molecular selective recognition and detection for target analyses. The preparation method of the artificial antibody comprises the steps of first, preparing Fe3O4 magnetic nanoparticles, and modifying their surface with polyethylene glycol; second, adding the target molecule thifensulfuron methyl, a crosslinking agent and a catalyst, and hydrolyzing to obtain Fe3O4@PEG@SiO2 particles with surface-marked thifensulfuron methyl; third, diluting template molecule with a mixed solution of acetic acid and acetone having a volume ratio of 1:4 to obtain the Fe3O4@PEG@SiO2 artificial antibody with selective recognition marker molecules, the antibody having maximum saturated binding capacity of 41.28 mg / g for thifensulfuron methyl, the absorption rate reaches 0.45 mg / g.min within first 30 min which is 5.34 times and 3.46 times that of a non-marking method.
Owner:HEFEI UNIV

Base material for tissue reconstruction, implantable material, and methods of preparing the same

Base materials for tissue regeneration which enable the tissue regeneration, have mechanical properties needed in the tissue regeneration and can disappear via degradation in vivo after the completion of the tissue regeneration; and implantable materials with the use of the same. The above-described base materials for tissue regeneration comprise polyrotaxane, wherein biocompatible groups having bulky substituents have been introduced via hydrolyzable bond into both ends of a linear molecule penetrating plural cyclic molecules, or a polyrotaxane hydrogel having a network structure formed by crosslinking the cyclic molecules to each other, the biocompatible groups to each other, or the cyclic molecules to the biocompatible groups in each polyrotaxane molecule.
Owner:JAPAN TISSUE ENG +1

Gas cell and coating method of gas cell

A gas cell to be filled with alkali metal atoms includes wall surfaces formed using a compound having polar groups or a material containing the compound, a first coating layer as a coating layer that coats the inner walls, formed using first molecules having functional groups to be chemically bonded to the polar groups and non-polar groups, and a second coating layer formed using non-polar second molecules on the first coating layer.
Owner:SEIKO EPSON CORP

Nanoparticles comprising a metal core and an organic double coating useful as catalysts and device containing the nanoparticles

The invention relates to novel nanoparticles comprising a metal core containing at least one platinoid or an alloy of a platinoid, a first organic coating formed from molecules attached to the surface of the metal core, and a second organic coating formed from molecules different from the molecules forming the first organic coating, and which are grafted onto molecules of the first organic coating. The invention also relates to the use of the nanoparticles as catalysts. The fields of application include devices for producing electrical energy, in particular in fuel cells, devices for detecting or assaying one or more chemical or biological species, in particular in sensors or multisensors, etc.
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Electro-polymerizable chemically-modified electrode organic material and application of electrode organic material in ultra-trace TNT (Trinitrotoluene) detection

The invention relates to an electro-polymerizable chemically-modified electrode organic material and application of the electrode organic material in ultra-trace TNT (Trinitrotoluene) detection and belongs to the field of electrochemical sensing technologies. The structural formula of the organic material is shown in the specification, wherein the molecular main chain skeleton consists of an A and two side units B. The A can be pyrene, naphthalene, anthracene, an anthracene derivative, phenanthrene, dibenzo-quinoxaline or the like; each B can be benzene, biphenyl, phenylene vinylene, fluorene or the like; each unit C is an electro-active unit and can be furan, pyrrole, thiophene, carbazole, diphenylamine, triphenylamine or the like. A connecting chain R for the molecular main chain skeleton and electrochemically-polymerized groups can be an alkyl chain, alkoxy chain or oxy chain. Carbazolyl groups can be subjected to crosslinking during electrochemical polymerization, and molecules can form spherical micro-nano structures due to crosslinking, so that on one hand, the contact specific surface area between the molecules of the organic material and TNT molecules is increased, on the other hand, due to pore structures formed among the micro-nano structures, TNT molecule diffusion paths are increased, and electrical signal response is enhanced.
Owner:陕西金士盾防务技术有限公司

Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using

A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety that directs the compound to a site a marker substance. The compound is chelated to a medically active material that generates a signal for diagnostic imaging or produces a therapeutic effect at the site of the marker substance. A method for detecting, diagnosing, and / or treating a disease that produces the marker substance uses a conjugate comprising the multifunctional cross-bridged tetraaza macrocyclic compound.
Owner:GENERAL ELECTRIC CO

Organometallic complex molecule and organic electroluminescent device using the same

Disclosed are new organometallic complex molecules having light-emitting and electron-transporting characteristics. Also disclosed is organic EL (electroluminescent) devices using these organometallic complex molecules as electron-transporting materials. The organometallic complex molecules are used to form a light-emitting layer with or without doping of another light-emitting material. The organometallic complex molecules can also be used in an electron-transporting layer of the organic EL device. The organic EL devices incorporating the organometallic complex molecules have high thermal stability.
Owner:LG CHEM LTD

Associative polymers for mist-control

Polymeric mist control materials, methods of forming polymeric mist control materials, and methods of using such materials for mist control are provided. The polymeric mist control additives are formed of molecules comprised predominantly of monomers that confer high solubility in fuel and include associative groups that attract each other in donor-acceptor manner, and are incorporated such that multiple associative groups are in close proximity (“clusters”), such that the clusters are separated by very long non-associative sequences.
Owner:CALIFORNIA INST OF TECH

Ionic hydrogen bond organic framework material as well as preparation method and application thereof

The invention belongs to the field of preparation of ionic hydrogen bond organic framework materials, and particularly discloses an ionic hydrogen bond organic framework material with proton conduction performance, the chemical formula of the ionic hydrogen bond organic framework material is {TPE-SO3H. 2 (DBD). 2 (DMF). 4 (H2O)} n, n is a positive integer, TPE-SO3H is 1, 1, 2, 2-tetrasulfonic acidphenyl ethylene, DBD is (C5NH4NH2) 22+, and DMF is N, N '-dimethylformamide. The structural unit belongs to a triclinic system, the space group is P-1, the molecular formula is C52H62N10O18S4, the cell parameters are as follows: alpha = 102.789 degrees, beta = 99.968 degrees and gamma = 112.169 degrees, each repetitive unit comprises four water molecules and two DMF molecules, two DBD molecules and one TPE-SO3H molecule, and amino groups on the DBD molecules and sulfonate groups on the TPE-SO3H molecule form a one-dimensional hydrogen bond network with water molecules. The material has good thermal stability, and has good performance for proton transportation. The invention discloses the preparation method of the material, the synthetic raw materials are easy to obtain, and the preparation process is simple. The ionic hydrogen bond organic framework material disclosed by the invention can be used as a proton conducting material and has a very good application prospect.
Owner:SHAANXI UNIV OF SCI & TECH

Ultratrace DNA detecting method by means of nano microsphere amplificaltion technology and piezoelectric DNA biosensor

On the quartz wafer a thin layer of gold film or silver film is plated, then the quartz wafer is vibrated to selectively adsorb DNA, and the hybridization of DNA molecule can be used to combine into double-chain DNA, then the nano microsphere of medicine of biological reagent which is marked to make selective action with double-chain DNA can be used to confirm target double-chain DNA molecule formation and make mass amplification so as to detect ultratrace target DNA. Its selectivity is strong and its sensitiveness is high.
Owner:WUHAN UNIV

Toner and Toner Binder

A polyester resin toner binder which gives a toner with good anti-blocking property at high temperature and high humidity and good low-temperature fixing ability. The present invention is directed to a toner binder for developing electrostatic charge images, which binder comprises a condensation-polymerization polyester resin, the polyester resin being a product formed in the presence of a catalyst (a) represented by the following general formula (I):Ti(—X)m(—OR)n  (I)wherein R is H or a hydrocarbon group having from 1 to 24 carbon atoms which may contain from 1 to 3 ether bonds and / or from 1 to 2 hydroxyl groups; X is a residue formed by removing H of one carboxyl group from an aromatic mono- or polycarboxylic acid, provided that in the case of a polycarboxylic acid, a carboxyl group other than said one carboxyl group may intra molecularly polycondense with an OR group in the same molecule to form a ring structure or may form a structure where it has polycondensed intermolecularly with an OR group in another molecule; m=1 to 3, n=1 to 3, and the sum of m and n is 4.
Owner:SANYO CHEM IND LTD

Co-crystal formed by 2,2',3,3'-tetrahydroxy dinaphthalene and 4,4'-dipyridyl and preparation method

The invention discloses a co-crystal formed by 2,2',3,3'-tetrahydroxy dinaphthalene and 4,4'-dipyridyl and a preparation method. The preparation method comprises the following steps: forming a co-crystal basic structure unit with one 2,2',3,3'-tetrahydroxy-1,1'-dinaphthalene molecule and one 4,4'-dipyridyl molecule through the action of O-H...N hydrogen bonds; forming a one-dimensional helical chain with the 2,2',3,3'-tetrahydroxy-1,1'-dinaphthalene molecule in the co-crystal through an O-H...O hydrogen bond between every two adjacent molecules; connecting the 4, 4'-dipyridyl molecule on the one-dimensional helical chain an O-H...N hydrogen bond to form a two-dimensional layered structure, wherein the overall structure of the co-crystal is the helical chain clathrate 4,4'-dipyridyl molecule formed by the 2,2',3,3'-tetrahydroxy-1,1'-dinaphthalene molecule. In the preparation method, the co-crystal is prepared by adopting a solution cooling crystallization method by taking acetonitrile and trichloromethane as solvents. The invention provides the preparation method for forming the co-crystal with polyphenol and a pyridine substance, so that a theoretical guiding significance is provided for preparation of the type of pharmaceutical co-crystals.
Owner:LUOYANG NORMAL UNIV

Multi-targeting antitumor composite preparation and preparation method thereof

The invention discloses a multi-targeting antitumor composite preparation and a preparation method thereof. The multi-targeting antitumor composite preparation comprises a Fu vesicle suspension, DOX-BSA and FA-DOX. A vesicle administration system is prepared through integrating immunotherapy, positive targeting chemotherapy medicine drug molecules and a passive targeting administration system realize in order to realize low toxicity and high efficiency treatment of tumors, and the vesicle administration system can obviously slowly release Fu to effectively containment tumor development and has small influences on tumor bearing bodies; a newly synthesized immunogen can obtain an antibody with high sensitivity, so foundation is laid for formation of an immune compound macromolecule required by immunotherapy; and the micro-molecular compound FA-DOX has a molecule bridging effect in immunotherapy to promote formation of the immune compound macromolecule. The composite preparation has obviously better curative effects than simple particle administration chemical treatment or simple immunotherapy, has obviously low toxicity, can improve the antitumor effect, and is an anticancer composite preparation with wide research and application prospect.
Owner:SUZHOU UNIV

Preparation method of biological binary composite adsorbent in glycerol triacetate refinement process

The invention provides a preparation method of a biological binary composite adsorbent in a glycerol triacetate refinement process, and aims at overcoming the deficiencies of relatively poor selectivity, easiness in saturation, non-ideal subsequent refinement effect, high use cost and the like due to adoption of single active carbon as an adsorbent for removing residual organic matters in a subsequent process of glycerol triacetate in the prior art. According to the method, the surface of active carbon is grafted and coated with cyclodextrin, so that the content of oxygen-containing groups on the surface of active carbon is increased, the characteristics of active carbon are added, and active carbon can form an inclusion compound and a molecular assembly system together with a large quantity of organic and inorganic molecules under the Van der Waals' force, the hydrophobic interaction force, the effect of matching between molecules of subjective and objective bodies and the like; the enveloping effect of selective combination is commonly known as the molecular identification, and finally a high-efficiency elution effect is achieved.
Owner:云南省玉溪市溶剂厂有限公司

Magnetic Nanoaggregate-Embedded Bead, Manufacturing Method Thereof and Bioparticle Detection Method Using the Same

A magnetic nanoaggregate-embedded bead (NAEB), a manufacturing method thereof and a bioparticle detection method using the same are disclosed. The magnetic NAEB has a protective nanoshell, noble metal nanoparticles, Raman reporter molecules and at least one magnetic nanoparticle. The protective nanoshell covers the noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle. The noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle form a magnetic nanoaggregate. Preferably, a chemical modification is performed on the magnetic NAEB, such that at least one targeting molecule is formed on an outer wall of the protective nanoshell, wherein a type of the targeting molecule is corresponding to a type of the bioparticle to be detected.
Owner:NATIONAL CHUNG CHENG UNIV

Organic nanotube having hydrophobized inner surface, and encapsulated medicinal agent prepared using the nanotube

Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus,In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22. Particularly, an asymmetric bipolar lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n is an integer of 18 to 22, both of Z1 and Z2 are single bonds, Y is Gly, m(s) is the same or different integer of 3 to 6, X is OH, and R is a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic acid based asymmetric nanotube by single component self-assembly or binary self-assembly.
Owner:NAT INST OF ADVANCED IND SCI & TECH

Organic nanotube having hydrophobized inner surface, and encapsulated medicinal agent prepared using the nanotube

Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus,In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22.Particularly, an asymmetric bipolar lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n is an integer of 18 to 22, both of Z1 and Z2 are single bonds, Y is Gly, m(s) is the same or different integer of 3 to 6, X is OH, and R is a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic acid based asymmetric nanotube by single component self-assembly or binary self-assembly.
Owner:NAT INST OF ADVANCED IND SCI & TECH

Short peptide derived from tumor antigen SAGE1

The invention relates to a short peptide derived from a tumor antigen SAGE1, a complex of the short peptide and an MHC molecule, and uses of the short peptide and the complex. Meanwhile, the inventionfurther relates to molecules bound with the short peptide or the complex and uses of the molecules.
Owner:XLIFESC LTD

Molecule immobilization method and its system

A simple, highly efficient, and environmentally friendly method of immobilizing macromolecules, particularly the biomolecules, to a solid carrier and thus forming a bioreactor, including the following steps: (1) providing the biomolecule and a leading molecule, and linking the biomolecule and the leading molecule by microwave to form an adsorbent; (2) providing a porous support material, and mixing the porous support material and the adsorbent to form a mixture; (3) treating the mixture by a vortex process such that the adsorbent being adsorbed and immobilized on the porous support material to form a bioreactor for biological reactions and biocatalysis; and the bioreactor can be further used for constructing a biological reaction system via incorporating a buffer solution and a ligand.
Owner:CHUNG YUAN CHRISTIAN UNIVERSITY
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