7results about "Nitro/nitroso group formation/introduction" patented technology

The invention discloses a preparation method of a C-H nitrated compound of unactivated aromatic hydrocarbon, which comprises the following steps: at room temperature, adding a compound 1, a nitro source, an oxidant, a catalyst and an organic solvent into a reaction tube, placing the reaction tube in an oil bath environment, and carrying out heating and stirring reaction; and after the reaction is finished, carrying out reduced pressure distillation on the reaction system, and purifying through a silica gel column to obtain a nitro compound product, namely a compound 2, with a reaction formula as shown in the specification. Wherein the number of substituent groups R on a benzene ring is 1-2, and each substituent group is independently selected from halogen, nitro, cyano, C1-C4 alkoxy, ester group, amino, pyrimidyl or pyridyl. According to the method disclosed by the invention, other leaving groups, reaction intermediates and guiding groups are not introduced in the reaction process, and the used nitro source does not cause adverse side reactions to the reaction and does not limit the application range of a substrate.

Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are kits including a nitrosation reagent. Provided are compositions wherein the nitrosation reagent is enriched in the 15N isotope.

This invention relates to the field of chemical reaction apparatus technology, specifically to a multi-stage swirling mixing tubular reactor and an adiabatic nitration process. The multi-stage swirling mixing tubular reactor includes a tubular reactor and a swirling feed nozzle, with the swirling feed nozzle located at one end of the tubular reactor. The swirling feed nozzle has a central feed channel and an annular feed channel radially arranged, coaxial with the tubular reactor. A central swirler is installed in the central feed channel, and an annular swirler is installed in the annular feed channel. This invention helps to solve the problems of uneven mixing and localized overheating in traditional adiabatic nitration reactions.

The invention relates to a nitration phase continuous flow nitration method. The method comprises the following steps: mixing a nitrating agent with a solvent 1 to obtain a nitration phase; dissolving and dispersing the raw materials through a solvent 2 to obtain a raw material phase; the nitration phase and the raw material phase are conveyed into a continuous flow reactor according to a certain flow velocity ratio, a nitration product is obtained after reaction, and continuous nitration synthesis is achieved. The nitrating agent comprises one or more of nitrate or a solid nitrating agent obtained by mixing nitrate and sulfate, grinding and sieving; nitrate, or a mixture of nitrate and sulfate, and a nitration auxiliary agent are mixed to obtain a solid nitrating agent; the fluid nitrating agent is prepared from nitrate, or a mixture of nitrate and sulfate, and water and / or a nitrating auxiliary agent; nitric acid is used as a nitrating agent; nitric acid and a nitration auxiliary agent are mixed to obtain a fluid nitrating agent; and nitrogen pentoxide. Compared with the prior art, the method provided by the invention has the advantages of no use of mixed acid, mild and controllable reaction conditions, less by-products, less amount of acid wastewater generated by the process and obvious industrialization prospect.

Use of nitrated aromatic organic compounds of claim 15 (nitroaromatics) for reducing the interfacial tension of the organ phase and acid phase and / or for improving the dispersibility of the organ phase and acid phase in adiabatic nitration reactions of the corresponding unnitrated aromatic organic compounds; wherein nitratable aromatic organic compounds (aromatics) are reacted in an adiabatic nitration reaction with a nitric acid / sulfuric acid-nitrating acid mixture to form the corresponding nitrated aromatic organic compounds (nitroaromatics); wherein the initial reaction mixture, which comprises the nitrateable aromatic organic compounds (aromatics) and the nitric / sulfuric acid-nitrous acid mixture, is supplemented with appropriate nitrated aromatic organic compounds (nitroaromatics), and the reaction and / or nitration reaction is initiated and / or carried out in the presence of the nitrated aromatic organic compounds (nitroaromatics); and / or . wherein the obtained nitrated aromatic organic compounds (nitroaromatics) are partially recycled back into the nitration reaction and the subsequent conversion and / or nitration reaction is started and / or carried out in the presence of the nitrated aromatic organic compounds (nitroaromatics); the conversion and / or nitration reaction is carried out under adiabatic reaction conditions; the process or conversion and / or nitration reaction is carried out in a tubular reactor.

The present invention relates to a novel method of synthesizing mononitrosylated and dinitrosylated propanediols and novel compositions and pharmaceutical formulations comprising said compounds. The method is carried out by reacting the corresponding non-nitrosylated propanediol with a source of nitrite, optionally in the presence of a suitable acid. Therein, when the source of nitrite is an organic nitrite, the reaction step is performed in a suitable organic solvent and when the source of nitrite is an inorganic nitrite, the reaction step is performed in a biphasic solvent mixture comprising an aqueous phase and a non-aqueous phase. The present invention further relates to methods of treating conditions in which the administration of nitric oxide (NO) has a beneficial effect, by administering said compounds, compositions or formulations.

Described is a process for the synthesis of mono- and bis-nitrosylated propanediols, as well as compositions and pharmaceutical formulations that includes the compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. When the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. Also disclosed are methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations.