The invention relates to a high-speed precise horizontal five-axis linkage aero-engine blade numerical control milling center, and belongs to the technical field of metal milling equipment, the high-speed precise horizontal five-axis linkage aero-engine blade numerical control milling center comprises a lathe bed and a stand column, the lathe bed is in sliding connection with the stand column, and a sliding seat is arranged on one side of the stand column; two parallel Z-axis guide rails are fixed to the side, close to the sliding seat, of the stand column, the Z-axis guide rails are arranged in the vertical direction, and two Z-axis sliding blocks which are in sliding connection with the two Z-axis guide rails correspondingly are fixed to the side, close to the stand column, of the sliding seat; and the stand column is provided with two Z-axis driving assemblies for driving the sliding seat to move up and down, a spindle box is arranged on the side, close to the lathe bed, of the sliding seat, a tool spindle is installed on the side, close to the lathe bed, of the spindle box, and a driving part for driving the spindle box to rotate is fixed to the side, away from the spindle box, of the sliding seat. The high-speed precise horizontal five-axis linkage aero-engine blade numerical control milling center has the effect of improving the overall rigidity of the milling center.