The invention belongs to the technical field of engineering material plates, and particularly relates to a manufacturing method of a heat preservation and noise isolation partition plate of a star island type structure system. The manufacturing method comprises the following steps: S1, preparing raw materials of the partition plate, specifically, putting the raw materials into a stirring barrel for mixing and stirring into porous slurry to serve as a base material of the partition plate for later use; S2, preparing filling materials, namely, building ceramsite, grit, perlite and polyphenyl particles, and sequentially feeding the filling materials into the stirring barrel for mixing and stirring with the base material; S3, adjusting the adding proportion of the four kinds of filling materials in the S2 through a proportional feeding device according to the requirements of customers and the use environment of the partition plate, and producing and preparing foundation structures with different specifications of weight, thermal resistance, strength, sound insulation and fire endurance; and S4, forming, specifically, attaching one of calcium silicate boards and cement surface layers to the two sides of each foundation structure, laying one or two of alkali gridding cloth and a metal net on the two sides and the middle position of each foundation structure, and carrying out drying and forming.