57results about How to "High-yield synthesis" patented technology

The present invention relates to novel tubulysin compounds (tubulysin analogues) as well as pharmaceutical formulations thereof. The present invention further relates to the use of such compounds for medicinal, agricultural, biotool or cosmetic applications. In particular, the novel tubulysin analogues show a cytostatic effect and can therefore be used for the treatment of proliferative disorders. The tertiary amide moiety of the tubulysin analogues (so-called tubugis) according to the present invention is generated by an Ugi-type reaction.

Disclosed is a nucleic acid amplification method which is based on a new principle and enables to amplify a nucleic acid having a specific nucleotide sequence in a simple manner, within a short time and with efficiency. The nucleic acid amplification method comprises the steps of: (a) conducting a DNA polymerase chain reaction by using, as a template, DNA comprising a nucleotide sequence to be amplified and using a primer pair having a nucleotide sequence complementary to the nucleotide sequence to be amplified, thereby producing a linear DNA fragment; and (b) conducting a chain-substituting DNA polymerase chain reaction in a chaining manner by using cyclic single-stranded DNA comprising the same nucleotide sequence as that of at least one of the primer pair as a template and employing the 3′-terminus of the linear DNA fragment produced in step (a) as the replication origin.

The invention relates to a PM catalyst for high intensity synthetic diamond, the percentage by weight of each component in terms of Co: 12 ~ 17%, Mn: 5 ~ 10%, C: 1 ~ 5%, surplus is Fe. Preparation, with metal powder and ball mill will be fully mixed toner, pre-Cold molding. Metal powder was spherical particle size of 100 to 300 head. After sintering and grinding the catalyst tablets treat the need size. In the actual production, the invention used as a catalyst at the high-pressure high-temperature (1300deg.C, 5.3MPa) complex synthetic diamond 40-60 coarse granularity in more than 85%, peak output static strength >= 13kg, in the proportion of 57% and above, the maximum static pressure Strength to 35. The oxygen content of catalyst <150PPm, is conducive to the growth of diamond-shaped, effectively raising the grade synthetic diamond. The massive iron replacement nickel, the overall price is lower than existing technology in the nickel manganese cobalt catalyst.

The invention relates to a method for synthesizing a Cu-SAPO-34 molecular sieve, a product and a use of the product. More specifically, the involved method comprises the synthesis of the Cu-SAPO-34 molecular sieve with a Cu-SSZ-13 molecular sieve as a Cu source, a part of silicon and aluminum sources and a crystal seed, wherein the Cu-SSZ-13 molecular sieve has high Cu content and is synthesized with a copper-amine complex as a template agent. The method not only can control the copper loading amount in an SAPO-34 molecular sieve in a certain wide range, but also can effectively control the content and distribution of silicon atoms in the molecular sieve, and has high product yield. The obtained Cu-SAPO-34 molecular sieve catalyst exhibits excellent hydrothermal stability and catalytic performance for selective reduction removal of NOx.

The invention relates to chemical synthesis for D-fluorescein. Wherein, using hot demethylate reaction to 2- cyano-6-methoxyl benzothiazole and pyridine hydrochloride with high purity to extract reaction production for column chromatography; finally, taking condensation reaction for demethylate production and D-cysteine to obtain objective product. This invention is simple, needs mild condition and easy to control. The product has yield more than 60% and purity more than 50%, and achieves level of Sigma L-9504 but with low price.

The invention belongs to the field of medical chemistry, and aims at providing a method for synthesizing trans-4-hydroxy-L-proline. According to the technical scheme, by virtue of genetiuc engineeringmodified escherichia coli, [alpha]-ketoglutaric acid, which is generated from autologous TCA circulation of a catalysis host, is converted into an L-proline gene, and the L-proline gene undergoes tandem and over-expression, so that the yield of L-proline is improved; and prolyl hydroxylase is introduced, so that a reaction that the L-proline is converted into the trans-4-hydroxy-L-proline and a reaction that the [alpha]-ketoglutaric acid is converted into succinic acid are coupled; therefore, the efficient synthesis of the trans-4-hydroxy-L-proline under a condition of not adding exogenous L-proline is achieved. The synthesis method of the trans-4-hydroxy-L-proline provided by the invention is optimized, so that the yield of the target product (the trans-4-hydroxy-L-proline) is greatly improved.

Provided is a method for manufacturing a carbonaceous luminescent material in which a polycarboxylic-acid-containing starting material, an acid catalyst, and a solvent are mixed together and heated.

Provided is a 5,6-diaryl-2-pyrazyl triflate, its synthetic method, and a method for synthesizing an organometallic complex having a triarylpyrazine ligand from the 5,6-diaryl-2-pyrazyl triflate. The triflate is readily obtained from the corresponding 5,6-diarylpyrazin-2-ol, and the palladium-catalyzed coupling of the 5,6-diaryl-2-pyrazyl triflate with an arylboronic acid derivative leads to a high yield of a triarylpyrazine derivative having high purity. The use of the triarylpyrazine derivative in the reaction with a metal compound such as a metal chloride results in an ortho-metallated organometallic complex with high purity. The high purity of the organometallic complex contributes to the extremely high durability of a light-emitting element.

Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and / or peptides.

The invention discloses a tenofovir preparation method. The method comprises reactions with equations shown in the specification; and in the equations, A is a C1-C4 alkylcarbonyl group or an aryl-substituted C1-C4 alkylcarbonyl group, B is H, a C1-C4 alkylcarbonyl group or an aryl-substituted C1-C4 alkylcarbonyl group, R is a C1-C3 alkyl group or a phenyl group, R' is H, a C1-C3 alkyl group or a phenyl group, a reaction a is characterized in that a compound of formula III reacts with (R)-propylene carbonate and dialkyl (tosyloxy)methylphosphonate to generate an intermediate II, and a reaction b is characterized in that the intermediate II is hydrolyzed under the action of an inorganic acid to remove a protection group in order to obtain tenofovir. The method can realize synthesis of highly pure tenofovir in low cost and high yield by using cheap and easily available raw materials through simple operation under mild reaction conditions, has the advantages of energy saving and environmental protection, is suitable for large scale production, and has significant values for realizing the industrial production of tenofovir.

A halogenated polysaccharide is provided having a halogen content of from about 1.0 wt. % to about 85 wt. % based on the total weight of the halogenated polysaccharide and having an average chain length of at least 6 monosaccharides. Methods of halogenating a polysaccharide to form a halogenated polysaccharide are provided that can be performed in the presence or absence of a proton solvent. Compositions such as articles of manufacture containing a halogenated polysaccharide and methods of producing such articles are also provided. The article of manufacture can also include one or more additional polymers, for example, polyvinylchloride (PVC). The article of manufacture can be, for example, a flooring tile, flooring plank, or carpet. Halogenated polysaccharides and products containing the same are bio-based, environmentally sustainable replacements or complements to existing polymers and polymer products.

The invention discloses an iron-based powder catalyst for synthesizing superfine particle diamond. The iron-based powder catalyst comprises the following alloy components in percentage by weight: 25 percent to 40 percent of Mn (manganese), 5 percent to 15 percent of Ni (nickel), 2 percent to 10 percent of Zn (zinc) and the balance of Fe (ferric). The iron-based powder catalyst has the advantages that the electron theory is used for instructing to select the main components of the catalyst alloy, the product sphericity is good, the chemical components are uniform, and the powder yield rate of 400 to 600 mesh granularity is not less than 80 percent; the percentage of 400-mesh diamond synthesized by the powder catalyst is not less than 85 percent, the integrity of diamond crystal is high, and the transparency degree is good; compared with the existing nickel-based catalyst for synthesizing the fine-particle diamond, the production cost of the iron-based powder catalyst disclosed by the invention is obviously reduced, and the economic benefit is obvious.

A process for preparing a platinum complex represented by the following formula (1) includes reacting a compound represented by the following formula (B-2) and a compound represented by the following formula (B-2′) with a compound represented by the following formula (A-0) to obtain a compound represented by the following formula (C-0); and reacting the compound represented by the formula (C-0) with a platinum salt:

The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient vorinostat. In particular it relates to a process for preparing vorinostat substantially free from impurities, involving suberic acid, aniline and hydroxylamine as starting materials.

Disclosed herein are the compounds shown below. Also disclosed are methods of making the compounds.R1=—O—;R2=any alkyl chain;R3=—CH3, —CN, —COOCH3, -tetrazole, -imidazole, or -triazole;R4=—H or —R5;R5=—H, -halogen, —C≡CH, or —C≡C—;n is a positive integer; andm is a positive integer.

The invention provides a synthesis method of medicine intermediate carbamate compounds. Compounds disclosed as Formula (I) and compounds disclosed as Formula (II) react in an organic solvent in the presence of a catalyst and a ligand to obtain carbamate compounds. The method implements high-yield synthesis of carbamate compounds, and has favorable application prospects.

The invention relates to a method for synthesizing a Cu-SAPO molecular sieve, a product and a use of the product. More specifically, the involved method comprises the synthesis of the Cu-SAPO molecular sieve with a Cu-SAPO molecular sieve as a copper source, a part of silicon, phosphorus and aluminum sources and a crystal seed, wherein the Cu-SAPO molecular sieve has high Cu content and is synthesized with a copper-amine complex as a template agent. The method not only can control the copper content in a SAPO molecular sieve in a wide range, but also effectively controls the silicon content and distribution of silicon atoms, and has high product yield. The obtained Cu-SAPO molecular sieve catalyst exhibits excellent high-temperature hydrothermal stability and catalytic selective reductionremoval performance for NOx.

The invention relates to a continuous flow microreactor, a manufacturing method and an application. The continuous flow microreactor comprises a pipe body, one end of the pipe body communicates with afeeding pipe and an air inlet pipe, the other end of the pipe body is open, a microreactor unit is arranged in the pipe body, and a plurality of micron-sized pore channels are distributed in the microreactor unit; the microreactor unit is made of a nano ferrite magnetic material, the microreactor unit comprises a preheating section and a catalytic reaction section which are distributed in the length direction of the pipe body, and the catalytic reaction section is close to the open end of the pipe body; and an induction coil sleeves the pipe body, two ends of the induction coil are electrically connected with a high-frequency power supply, and the magnetic heating effect of nano magnetic particles in an external alternating magnetic field has the advantages of high efficiency, easiness incontrol, targeting and the like, and has the advantages of good temperature uniformity, low energy consumption, high efficiency, simple structure, convenience in use, easiness in system integration and scale amplification and the like. High-purity and high-yield synthesis of a target product in a fine chemical product process can be realized.

Provided is a method for manufacturing a carbonaceous luminescent material in which a polycarboxylic-acid-containing starting material, an acid catalyst, and a solvent are mixed together and heated.

The invention discloses a synthesis process of a thiazole substituted pyrimidine compound shown in a formula (I). The synthesis process comprises a thiazole cyclization reaction and a pyrimidine cyclization reaction. The synthesis process disclosed by the invention adopts unique reactants and a comprehensive reaction system, so that high-yield synthesis of the thiazole substituted pyrimidine compound is realized, reaction selectivity and operation controllability are improved, production of the thiazole substituted pyrimidine compound is more controllable, and the new sought synthesis processof the thiazole substituted pyrimidine compound is highly significant to an economic technology of the thiazole substituted pyrimidine compound. (The formula (I) is described in the specification).

Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane- associated polypeptides.

The invention relates to a synthesis method of a medical intermediate phenanthridone compound. The method comprises the following step of reacting an N-methoxybenzamide compound with an aniline compound in an organic solvent in the presence of a copper catalyst, a cocatalyst, an oxidizing agent and isoamyl nitrite to obtain the phenanthridone compound. According to the method, through unique substrate section and a unique comprehensive reaction system, high-yield synthesis of the phenanthridone compound is achieved and the method has a good application prospect and industrial production potential.

The present invention discloses oxindole compounds and a single step, one pot reaction for the synthesis of oxindole derivates via a solvent free Passerini reaction of isocyanides, isatins and carboxylic acids.

The invention provides an aryl pyridone compound preparation method which includes the step: reacting N-methyl-2-pyrolidone and aromatic heterocyclic boronic acid in organic solvents under rhodium catalysts and ligands to obtain aryl-substituted pyridone compound. According to the method, high-yield synthesis of the aryl pyridone compound is achieved, and the aryl pyridone compound has good application prospect and industrial production potential.