The invention provides a seawater desalination preparation device, comprising a water inlet unit (a), a pretreatment unit (b) and a reverse osmosis unit (c) which are connected according to the water inflow sequence, wherein, the water inlet unit (a) is used for sending seawater to be desalinized to the pretreatment unit, and the seawater to be desalinized is drainage of uniflow circulated cooling water from an electric power plant; the pretreatment unit (b) comprises a precipitation device and a filtration device which are connected according to the water inflow sequence, wherein, the upper stream of the precipitation device is connected with a water inlet unit, while the down stream of the precipitation device is connected with the filtration device; and the reverse osmosis unit (c) comprises a boost device, an energy recovery device and a reverse osmosis device which are connected according to the water inflow sequence, wherein, the upper stream of the boost device is communicated with the filtration device in the pretreatment unit, while the down stream of the boost device is communicated with the reverse osmosis device. The seawater desalination preparation device has low cost, thereby the device can be popularized in a large scale and protect environment with scale merit, and can be used for preparing ultrapure water.