1results about How to "No coalescence" patented technology

The application relates to the technical field of fine chemical production, and particularly discloses a crystallization process of short-rod-shaped ivermectin, which comprises the following steps: dissolving ivermectin crude product in a crystallization solvent, heating to 50-55 DEG C, adding a crystallization agent, uniformly mixing, then cooling to 35-40 DEG C at a rate of 0.1-0.3 DEG C / min, adding ivermectin crystal seeds, continuously cooling to 5-15 DEG C, and incubating and crystallizing to obtain ivermectin products. The crystallization process of ivermectin provided by the application realizes effective control of the particle size and crystal habit of ivermectin products in the crystallization process by adopting a combination strategy of selecting a specific crystallization solvent, adding a crystallization agent and crystal seeds at specific stages, controlling the cooling rate and the incubation time, obtaining short-rod-shaped ivermectin products with uniform particle size distribution, and the products have good fluidity, are convenient for subsequent preparation application, do not need repeated crystallization for multiple times, effectively reduce the cost of the crystallization process, and have extremely high practical application value.