34results about How to "No coalescence" patented technology

The invention discloses a coated particulate preparation method, comprising the following steps: firstly, particulates in movement are coated with coating solution to cure the solution to form films; the coating rate and curing rate are controlled to ensure that the particulates reach the designed coating quantity while avoiding accumulation; then, the organic polymer films outside the coating films of particulates in movement are cured; inert organic substance is added to form continuous inert liquid membranes outside the organic polymer films before the particulates are likely to accumulate on the adopted coating film curing process conditions; then, the organic polymer films outside the particulates are continuously cured to lose autohension or so that the whole coating films are cured fully; and finally, the particulates coated films are cooled to the room temperature to obtain the coated particulates. The preparation method of the invention has high coating efficiency and good coating integrity and coating process.

The invention discloses equipment and a method for producing uniform particle ion exchange resin beads. The equipment comprises a head tank 1, an oil phase storage tank 2, a vibration generator system 4, a nozzle 6, a fluidized polymerization reactor 8, an aqueous phase liquid distributer 9, a maturation tank 10 and an aqueous phase circulating pump 11; and the ion exchange resin beads produced by the equipment have uniform particle size. When the method is used for producing the ion exchange resin bead products, the production capacity of the equipment can be adjusted by changing the number of orifices of the nozzle and the mass fraction of the target particle size of +/-0.05mm is more than 95 percent without sieving; and in the method, the aqueous phase can be recycled, so that the wastewater discharge is reduced; therefore, sewage discharge in the reaction process is greatly reduced.

The invention relates to a method for producing crystals of cefadroxil monohydrate, comprising the following steps: adding an N, N-dimethyl formamide solvent compound of cefadroxil to a mixed solvent of N, N-dimethyl formamide and water, wherein the mass ratio of the cefadroxil solvent compound to the mixed solvent is 1:1-1:2, stirring to obtain a suspending liquid, and keeping the temperature at15-30 DGE C and the pH value of the solution at 6.0-7.5 during feeding; after the cefadroxil solvent compound is totally changed into the cefadroxil monohydrate, reducing the pH value of the suspending liquid to 4.5-5.0 within 1-20 minutes, keeping the temperature at 10-18 DEGC, and stirring for crystal cultivation for 10-90 minutes; and filtering, washing and drying after crystal cultivation is finished to obtain a product, the square platy crystal-form cefadroxil monohydrate. The square platy crystal-form cefadroxil monohydrate obtained by the method has uniform particle size distribution, does not generate coalescence, and is applicable to industrial production.

The invention relates to a hydrate of micheliolide dimethylamine fumarate, a preparation method and application thereof, wherein the hydrate is a crystal form D, is high in crystallinity, smooth in particle surface, free of coalescence, high in bulk density and good in flowability, and has good stability and good reproducibility. The preparation method comprises the following steps: under stirringeffect, adding dimethylamine micheliolide and fumaric acid into a mixed solvent system with a constant temperature of 30-70 DEG C, carrying out reaction crystallization; and filtering after the reaction is finished, and drying the filtered solid at normal pressure to obtain the micheliolide dimethylamine fumarate crystal form D. The preparation method is simple, the product yield is high, and themethod is suitable for later preparation of patent medicines, and is beneficial to large-scale production.

The invention discloses a Pickering double emulsion with an interface stabilized by solid lipid, as well as a preparation method of the Pickering double emulsion and an application of the Pickering double emulsion to low-lipid foods. According to the interface provided by the invention, lipid crystals are formed in situ at the interface through the emulsifying property of solid lipid and the template effect of a lipophilic interface crystallization inducer, the lipid crystals are used for assisting in stabilizing the emulsion, the overall stability of the emulsion is enhanced, based on the condition that the consumption of an emulsifying agent, a stabilizing agent and gelata is reduced, a coalescence phenomenon does not occur after the emulsion is placed for one month, and instability caused by a processing or compounding process can be effectively improved. Through in vitro digestion experiments, the inventor find that the solid lipid interface layer of the prepared Pickering double emulsion W1/O/W2 partially inhibits the digestion of lipase to liquid oil, the emulsion has the characteristic of low lipid digestibility, and the application of the food-grade Pickering emulsion in the fields of food processing and low-lipid food can be widened.

The invention relates to a dimethylaminomicheliolide fumarate crystal form C and a preparation method thereof, wherein X-ray powder diffraction results show that the crystal form C has characteristicpeaks at 2[theta] of 6.4+/-0.2 DEG, 7.4+/-0.2 DEG, 11.6+/-0.2 DEG, 12.1+/-0.2 DEG, 13.1+/-0.2 DEG, 14.5+/-0.2 DEG, 15.1+/-0.2 DEG, 15.5+/-0.2 DEG, 15.9+/-0.2 DEG, 18.3+/-0.2 DEG, 18.6+/-0.2 DEG, 19.3+/-0.2 DEG, 19.8+/-0.2 DEG, 20.5+/-0.2 DEG, 22.0+/-0.2 DEG, 22.5+/-0.2 DEG, 22.9+/-0.2 DEG, 23.9+/-0.2 DEG, 24.4+/-0.2 DEG, 25.5+/-0.2 DEG, 26.2+/-0.2 DEG, 26.9+/-0.2 DEG, 27.4+/-0.2 DEG, 28.1+/-0.2 DEG, 29.3+/-0.2 DEG, 29.5+/-0.2 DEG, 30.6+/-0.2 DEG, 31.0+/-0.2 DEG and 31.5+/-0.2 DEG, wherein the characteristic peak at 6.4+/-0.2 DEG is an initial peak, and the relative intensity of the characteristic peak at 7.4+/-0.2 DEG is 100%. According to the invention, the preparation process is constant-temperature suspension crystal transformation preparation, the process method is simple, easy to operate and good in reproducibility, the purity of the obtained product is 99% or above, the yield is higher than 90%, the stability is good, the bulk density is high, the surface is smooth, the completerod-like crystal habit is achieved, and the method is suitable for large-scale production.

The invention relates to an ultrasonic-assisted coenzyme Q10 crystallizing method which comprises following steps: adding coenzyme Q10 with a purity being 90-95% to an organic solvent, wherein a mass ratio of the raw material to the organic solvent is 20-40:100; stirring the mixture and increasing the temperature to 50-60 DEG C for completely dissolving the coenzyme Q10 to form a uniform solution; performing a cooling crystallization process; decreasing the temperature of the solution to 36-40 DEG C with the ultrasonic-assisted crystallization being carried out for 5-20 min; decreasing the temperature of the solution to 13-20 DEG C; and performing filtration, a washing operation and a drying operating to obtain a coenzyme Q10 crystal product. The method is short in crystallization time. The coenzyme Q10 crystal product has a large granularity of about 70 [mu]m and is uniform in distribution. The solution is easy to filter and dry, is good in flowability and is free of coalescence. A single-way crystallization yield is higher than 90%. The purity of the coenzyme Q10 crystal product is higher than 99.0%. The method is convenient to operate, is low in cost, is less in energy consumption, is free of generation of harmful wastes and is suitable for industrial production.

The present invention relates to an apparatus for preparing cremated body crystalline grain which manufactures the collected bone powder into crystallized bones in the form of small bells. This crystallized bone manufacturing machine includes: a bone powder hopper and a heating furnace which is supported on one side of the housing by a supporting shaft, the supporting shaft is provided with a rotating handle on one end and a heating mechanism is disposed to surround the heating furnace as a heat source. The apparatus further includes: a spindle plate provided on the lower side of a discharge port of the heating furnace; an oscillating container of the spindle plate; a support bracket, one end of which is supported and fixed in a housing to support the spindle plate and the oscillating container; a cooling collector arranged on the right bottom of the oscillating container, and a plurality of blowers to cool and collect the generated crystallized bones passing the spindle plate and the oscillating container.

The invention relates to a high molecular weight acrylic resin for a polyvinylidene fluoride coiled material finish paint. The acrylic resin is combined with polyvinylidene fluoride resin as a coiled material finish paint base-material, is a bead-shape transparent particle and has a number-average molecular weight Mn higher than 90 thousand and molecular weight distribution Mw / Mn less than 2.0. The resin of the invention is prepared by a suspension polymerization method from material monomers of 50-80 wt% of methyl methacrylate and / or methyl acrylate, 10-40 wt% of ethyl acrylate and / or methyl methacrylate and 0-40 wt% of one or more selected from acrylic acid, hydroxyethyl acrylate, hydroxypropyl acrylate, methacrylic acid, hydroxyethyl methacrylate, hydroxypropyl methacrylate, butyl acrylate and butyl methacrylate. The high molecular weight acrylic resin of the invention can be combined with a PVDF resin, and a prepared finish paint film has comprehensive properties the same as an imported one and better performances on MEK-resistant wiping frequency and artificial ageing resistance.

The invention relates to the technical field of pesticide preparations and specifically relates to a pleocidin synergistic water emulsion and a preparation method thereof. The water emulsion is prepared from the following raw materials in parts by weight: 1-15 parts of pleocidin, 10-25 parts of capsule shell material, 10-15 parts of organic solvent, 3-7 parts of emulsifying agent, 1-5 parts of synergist, 0.5-2.5 parts of wetting dispersant, 1-3 parts of surfactant, 1-3 parts of thickening agent, 2-4 parts of anti-freezing agent, 3-5 parts of penetrant, 0.3-0.7 part of defoaming agent and 50-70parts of deionized water. The pleocidin synergistic water emulsion disclosed by the invention is good in fast-acting property, efficient in dispersion, stable and durable in pesticide effect, long instorage validity, capable of reducing the consumption of a poisonous and harmful solvent, environment-friendly and safe.

The invention provides a method for crystallizing phenylacetyl-7-amino-3-deacetoxycephalosporanic acid controllable in particle size and crystal habit. The method includes the following steps that a phenylacetyl-7-amino-3-deacetoxycephalosporanic acid crude product is added into ammonia water and uniformly mixed, and the mixture is filtered to obtain a phenylacetyl-7-amino-3-deacetoxycephalosporanic acid solution; hydrochloric acid is added into the phenylacetyl-7-amino-3-deacetoxycephalosporanic acid solution under the stirring condition at the temperature of 5-30 DEG C and at the speed of 90-180 r/min, the pH value is adjusted to be 1.5-3.0, crystal growing is conducted for 1-5 hours, and the phenylacetyl-7-ADCA is obtained. The purity of the phenylacetyl-7-ADCA prepared through the preparation method of the phenylacetyl-7-ADCA can reach 99.7%, the phenylacetyl-7-ADCA is in a long bar shape or a needle shape in the aspect of crystal habits, and the phenylacetyl-7-ADCA has the advantages of being complete in crystal habit, high in purity, good in liquidity, not prone to coalescence and the like, and has wide application prospects.

The invention relates to a pyraclostrobin crystal form and a preparation method thereof. The pyraclostrobin crystal form is characterized in that X-ray powder diffraction shows characteristic peaks when 2theta is 8.8+/-0.1 degrees, 9.0+/-0.1 degrees, 9.2+/-0.1 degrees, 11.8+/-0.1 degrees, 12.7+/-0.1 degrees, 14.7+/-0.1 degrees, 15.3+/-0.1 degrees, 17.8+/-0.1 degrees, 18.7+/-0.1 degrees, 22.2+/-0.1 degrees, 22.6+/-0.1 degrees, and 25.6+/-0.1 degrees. The preparation method comprises the following steps: dissolving a pyraclostrobin crude product in dichloromethane or a mixed solvent containing the dichloromethane; stirring and dissolving until a solution becomes clear; precipitating a crystal by evaporating or cooling and crystalizing; filtering crystal mush, washing and drying to obtain the pyraclostrobin crystal form. The method disclosed by the invention is easy to operate, the yield of a crystalizing process is 90 to 98 percent, the HPLC (High Performance Liquid Chromatography) detection purity of a product is 99.9 percent, and the product is a yellow crystal, has a flaky crystal habit, is smooth in surface and regular in edges, and has higher practical application value.

The invention provides a heptahydrate crystal and a preparation method. The preparation method includes the following steps that 1, sulfuric acid is dissolved in reaction liquid, and the reaction liquid is binary solvent and/or crystallization mother liquor of alcohol and water; 2, a zinc source is added, the molar ratio of the zinc source to sulfuric acid is controlled to be 1:1+/-0.1), and a reaction is conducted for a certain time; 3, sulfuric acid is supplemented, the molar ratio of the supplemented sulfuric acid and the zinc source added in step 2 is controlled to be (0.05-0.25):1, and the reaction is continued for a certain time; 4, after the reaction is ended, a solution is cooled and separated, the separated solid is subjected to postprocessing, and a product of the heptahydrate crystal is obtained. The product of the heptahydrate crystal has obvious prism-shaped crystallization habit, and dewatering endothermic peaks exist at the temperature of 75+/-1 DGE C, the temperature of 103 +/-1DEG C, the temperature of 124+/-1 DEG C and the temperature of 276+/-1 DEG C of a differential scanning calorimetric curve.

The invention relates to an alkane dehydrogenation reaction strengthening system and method. The alkane dehydrogenation reaction strengthening system comprises a liquid-phase feeding unit, a gas-phasefeeding unit, a micro-interface generator, a reactor and a separation tank, wherein the liquid-phase feeding unit is used for storing and conveying C5 or above C5 alkane. According to the invention,gas is crushed to form micron-scale micro-bubbles, and the micro-bubbles are mixed with alkane to form a gas-liquid emulsion, so that the phase contact area of a gas phase and a liquid phase is increased, the effect of enhancing mass transfer within a lower preset operation condition range is achieved, and the energy consumption can be greatly reduced while the reaction efficiency is ensured; andmeanwhile, mass transfer is greatly enhanced, so that the gas-liquid ratio can be greatly reduced, and the energy consumption of subsequent gas circulation compression is reduced while the gas material consumption is reduced.