2results about How to "Sensitive judgment" patented technology

This invention relates to the field of intelligent medical devices and precision drug delivery technology, and discloses a biofluid-assisted intelligent drug release triggering and control method that responds to the wound microenvironment. The method includes: collecting multi-parameter sensor signals such as pH, temperature, and biomarker concentration from the wound microenvironment, and performing preprocessing and feature extraction; calculating a fusion trigger index based on a dynamic weighted fusion algorithm to generate graded release level signals; employing a nested outer and inner loop dual-mode adaptive control structure to dynamically adjust control parameters according to the release level and real-time deviation, generating precise drive control quantity setpoints; further, predicting wound trends based on short-term historical data, and prospectively optimizing the control target based on a clinical rule knowledge base. This invention solves the problems of rigidity, lag, and inaccuracy of traditional local drug delivery methods, achieving intelligent closed-loop, adaptive, and prospective drug release regulation for complex dynamic wound microenvironments, significantly improving treatment efficacy and safety.

The application belongs to the field of food packaging and food detection, and particularly relates to a method for preparing an amine response type nanofiber indicating film by electrospinning and food freshness detection application thereof, and comprises the following steps: taking polycaprolactone as a film forming base material, polydiacetylene as an indicator, and polyacrylic acid as an auxiliary agent, preparing a nanofiber film by electrospinning technology, and preparing an amine response type nanofiber indicating film through ultraviolet lamp irradiation; the amine response type nanofiber indicating film prepared by the application has good biological safety and mechanical performance, the indicating film added with polydiacetylene and polyacrylic acid can produce obvious color change to low-concentration biological amine, and can effectively indicate the freshness change condition of shrimp and other meat food during transportation and storage. The food freshness intelligent indicating film prepared by the method has wide application value in the field of food intelligent packaging.