The invention belongs to the technical field of traditional Chinese medicine and particularly relates to application of a medicine composition containing folium artemisiae argyi to preparing medicine for treating the irritable bowel syndrome.The medicine composition is prepared from, by weight, 13-28 parts of folium artemisiae argyi, 20-24 parts of roxburgh roses, 11-19 parts of malt, 11-17 parts of cortex phellodendri, 6-15 parts of radix astragali, 8-17 parts of flos carthami, 6-14 parts of coix seeds, 9-18 parts of Chinese yam, 3-12 parts of fructus aurantii immaturus, 5-21 parts of poria cocos, 3-12 parts of radix angelica sinensis, 4-9 parts of lotus seeds and 6-10 parts of licorice roots.The medicine composition accords with the compatibility principles of monarch, minister, assistant and guide, components are reasonable, major and minor components are clear, and the components mutually gain.The medicines are coordinating and have the functions of invigorating the spleen and strengthening mid-energy, removing dampness and removing stagnancy, clearing dampness and promoting diuresis, harmonizing intestines and the stomach, promoting qi circulation and promoting digestion and relieving distension and stopping diarrhea.Raw materials are low in cost, the preparation technology is simple, the treatment effect is good, pertinence is high, universality is good, safety is high, and the application is suitable for clinical popularization.