60 results about "Di block copolymer" patented technology

A pattern having exceptionally small features is formed on a partially fabricated integrated circuit during integrated circuit fabrication. The pattern comprises features formed by self-organizing material, such as diblock copolymers. The organization of the copolymers is directed by spacers which have been formed by a pitch multiplication process in which spacers are formed at the sides of sacrificial mandrels, which are later removed to leave spaced-apart, free-standing spacers. Diblock copolymers, composed of two immiscible block species, are deposited over and in the space between the spacers. The copolymers are made to self-organize, with each block species aggregating with other block species of the same type.

A method and associated structure. A substrate is provided. The substrate has an energetically neutral corrugated surface layer. A film is formed on the corrugated surface layer. The film includes a combination of a di-block copolymer and a stiffening compound. The di-block copolymer includes lamellar microdomains of a first polymer block and lamellar microdomains of a second polymer block. The stiffening compound is dissolved within the first polymer block. At least one lamellar microdomain is removed from the film such that an oriented structure remains on the surface layer.

A method of controlling both alignment and registration (lateral position) of lamellae formed from self-assembly of block copolymers, the method comprising the steps of obtaining a substrate having an energetically neutral surface layer comprising a first topographic “phase pinning” pattern and a second topographic “guiding” pattern; obtaining a self-assembling di-block copolymer; coating the self-assembling di-block copolymer on the energetically neutral surface to obtain a coated substrate; and annealing the coated substrate to obtain micro-domains of the di-block copolymer.

A medical device or component thereof, and particularly intracorporeal devices for therapeutic or diagnostic uses, formed at least in part of a copolymer having a hard block and a polylactone soft block. In a presently preferred embodiment, the hard block of the copolymer is a polyester, and more specifically, the copolymer comprises a di-block copolymer of poly(ethylene terephthalate) and polycaprolactone. The copolymer is suitable for forming a variety of medical devices or medical device components, and is preferably used to form a catheter balloon, such as a balloon for an angioplasty or stent delivery catheter. However, a variety of medical devices or medical device components can be formed of the copolymer, including stent covers, vascular grafts, and shaft components.

The present invention is directed to controlling aggregation of rare earth particles using block copolymers and rare earth base particles. More particularly, invention is also directed to forming stable complexes of rare earth aggregates by complexing rare earth base particles with oppositely charged-neutral di-block copolymers. Even more particularly, invention is also directed to forming stable complexes of rare earth nanoparticles by complexing rare earth ultrafine particles with oppositely charged-neutral di-block copolymers.

The invention belongs to the field of medicines, and in particular relates to DOTAP-mPEG-PLA nanoparticles, a solution of the nanoparticles, a medicine-carrying compound as well as a preparation method and an application. The invention aims at providing an amphiphilic mPEG-PLA diblock copolymer modified by DOTAP, and a novel biodegradable gene carrier, namely, the DOTAP-mPEG-PLA nanoparticles (DPP nanoparticles for short) is prepared through a self-assembly method. The DPP nanoparticles have good DNA binding capacity, gene plasmids can be effectively guided into cancer cells, and the advantages of high transfection efficiency and low cell toxicity are achieved.

The invention provides a double stimuli responsive type poly amino acid based supermolecular reverse gel used in the technical field of water gel and a method for preparing the same, wherein the method comprises the following steps of: synthesizing a linear poly(L-benzyl-glutaric acid ester)-polyethylene glycol diblock copolymer; preparing a poly(L-glutamic acid)-polyethylene glycol di-block copolymer used for forming the reverse gel; forming the supermolecular reverse micelle in which the alpha-cyclodextrin-polyethylene glycol complex serves an inner core and the poly(L-glutamic acid) servesa shell; and protonating the poly(L-glutamic acid) chain segments in an acid environment, forming crosslinking by using the mutual action of the hydrogen bonds between the poly(L-glutamic acid) chainsegments, and allowing the supermolecular reverse micelles to mutually gather to form the double stimuli responsive type poly amino acid-based supermolecular reverse gel at room temperature. Comparedwith the prior art, the elastic modulus of the gel is further improved, the gel system prepared by the method is damaged when the pH value of the gel system is higher than 8, the reverse gel can be formed again when the pH value of the gel system is adjusted to be 5, so that the pH value reversibility is good.

The invention relates to a process for synthesizing an organosilicon two-block copolymer, which relates to the synthesis of a novel organosilicon low-surface energy two-block copolymer, in particular relates to process for preparing target polymer namely dimethyl silicone polymer-b-poly ethyl methacrylate through atoms transfer and free radical polymerization under the co-catalysis of utilizing macromolecule dimethyl silicone polymer to be macromolecule initiating agent, utilizing Cu(I)Br to be catalyst and utilizing N-(n-propyl)-2-pyridine methanamine to be catalyst ligand. And the invention provides a process for synthesizing an organosilicon two-block copolymer which has the advantages of separated micro phase, moderate reaction temperature, accurate structure of reaction products, and simple operation. And the invention relates to the copolymer of dimethyl silicone polymer-b--polymethyl methacryate-b-poly seven-fluorine butyl methacrylate ester. The process for preparation comprises first preparing preparing dimethyl silicone polymer macromolecule initiator of the sealing end of bromine atom, second, preparing a novel silicon-acrylic two-block material of the dimethyl silicone polymer-b-polyethyl methacrylate.

The invention specifically relates to an additive composition applicable to viscosity reduction of an oil-based drilling fluid and application thereof, and the oil-based drilling fluid and application thereof. The additive composition is a double block copolymer which is composed of a block A and a block B, wherein the block A is composed of a constitutional unit as shown in a formula (1) which is described in the specification and has a number-average molecular weight of 1500 to 10000, and the block B is composed of a constitutional unit as shown in a formula (2) which is described in the specification. The double block copolymer can be used as a viscosity reducer for the oil-based drilling fluid, especially as a viscosity reducer for a high-density clay-free oil-based drilling fluid; and the double block copolymer can greatly reduce the apparent viscosity and plastic viscosity of the oil-based drilling fluid in high-temperature high-pressure strata while guaranteeing proper shearing force, so drilling speed can be conveniently accelerated and difficulty in well drilling can be reduced.

The present invention relates to a thermoplastic resin composition, more precisely, a thermoplastic resin composition with enhanced impact resistance, gloss, weather resistance and scratch resistance, compared with the conventional thermoplastic resin compositions, by containing an acrylate-styrene-acrylonitrile (ASA) graft copolymer, an aromatic vinyl compound and vinyl cyan compound copolymer, an alkyl methacrylate / aromatic vinyl compound / vinyl cyan compound terpolymer and a di-block copolymer (aromatic vinyl compound / vinyl cyan compound-alkyl methacrylate / aromatic vinyl compound / vinyl cyan compound).

A fluorine silicon diblock copolymer and a relative preparation method relate to a fluorine silicon low surface energy diblock copolymer. The invention provides a fluorine silicon diblock copolymer (dimethyl silicone polymer-b-polyheptafluorobutyric methacrylate ester copolymer) and a relative preparation method, with mild reaction conditions, definite product structure, kept skeleton structure of each block and simple operation, wherein the fluorine silicon diblock copolymer is dimethyl silicone polymer-b-polyheptafluorobutyric methacrylate ester copolymer. The preparation method comprises preparing dimethyl silicone polymer macromolecule inducer terminated by bromine atom and preparing dimethyl silicone polymer-b-polyheptafluorobutyric methacrylate ester copolymer.

The invention relates to a two-block copolymer with multiple environmental responsibilities and a preparation method thereof. The temperature-sensitive monomer is first initiated to be polymerized using the initiators and the chain transfer agents so as to form the macromolecular transfer reagents by adopting the reversible addition-fragmentation chain transfer living radical polymerization RAFT method and then the photosensitive monomer and the pH value sensitive monomer are initiated to be copolymerized with each other using the initiators and macromolecular transfer reagents so as to prepare the two-block copolymer, thus preparing a novel two-block copolymer with multiple environmental responsibilities by introducing three monomers having the temperature, pH and photo responsibilities in the same polymer chain. The aqueous solution of the two-block copolymers has response characteristics over the temperature, pH value and light, and simultaneously the introduced photo-sensitive monomer can be optically dimerized and also can be photolyzed under different wavelengths, so the two-block copolymer can form a plurality of aggregation morphologies, and the reversible transformation between the dissolution and insolubilization of the two-block copolymer can be realized, thus ensuring that the two-block copolymer has a wider application value.

Disclosed are self-assembling block copolymers including diblock copolymers of the formula (I):wherein R1 is —(CHR—CH2—O)p—R′, p=2-6, R is H or methyl, and R′ is H, a C1-C6 alkyl or C3-C11 cycloalkyl, R2 is C6-C20 aryl or heteroaryl, one of R3 and R4 is C6-C14 aryl and the other is C1-C22 alkoxy, and n and m are independently 2 to about 2000, which find use in preparing self-assembled structures and porous membranes. Embodiments of the self-assembled structures contain the block copolymer in a cylindrical morphology. Also disclosed is a method of preparing such copolymers.

A chewing gum base which is cud-forming and chewable at mouth temperature contains a food acceptable tri-block copolymer having the form A-B-A or A-B-C and comprising a soft mid-block which constitutes at least 30 wt. % of the total polymer and hard end-blocks each having a glass transition temperature below 70° C. The tri-block copolymer is optionally plasticized with a compatible di-block copolymer to function as an elastomer system in the gum base.

Chewing gums and chewing gum bases which are cud-forming and chewable at mouth temperature contains a multi-block copolymer having at least two repeating sequences of at least two different polymeric blocks having at least three monomer units each. The multi-block copolymer optionally includes linking units and may be formulated to have non-covalent crosslinking between the copolymer chains. The multi-block copolymer is optionally plasticized with a compatible di-block copolymer to function as an elastomer system in the gum base. Characteristics of the multi-block copolymers can be selected to produce gum bases and chewing gums having desired properties. In some cases, chewed cuds formed from the gum bases may exhibit improved removability from environmental surfaces to which they may become undesirably attached.

The invention discloses a degradable copolyester which is a random copolymer or a double-block copolymer composed of polyester fragments which are difficult to hydrolyze and fragments or sites which are easy to hydrolyze, wherein the number-average molecular weight of the copolyester is 30000 g / mol to 500000 g / mol; and the fragments or sites which are easy to hydrolyze are selected from polylactic acid with different chain segment lengths. The copolyester is high in molecular weight, free of environment-unfriendly chain extenders, good in mechanical strength and toughness, resistant to heat and good in processability, and can be independently used as plastic. In various natural environments such as water, soil, compost and the like, the copolyester can be completely degraded in the natural environments to form environment-pollution-free carbon dioxide and water. The invention also discloses a preparation method and application of the degradable copolyester.

Provided are a BAB-type tri-block copolymer including a polylactic acid (A) that is a hydrophobic block and polyethylene glycol (B) that is a hydrophilic block, a method of preparing the BAB-type tri-block copolymer including synthesizing a polylactic acid (A)-polyethylene glycol (B) di-block copolymer by a ring opening polymerization of a lactic acid monomer using a hydroxyl group of polyethylene glycol (B) as a polymerization initiator; and synthesizing a BAB-type tri-block copolymer by reacting the AB-type di-block copolymer with polyethylene glycol (B) including at least one carboxyl group at one or more terminals thereof in the presence of a coupling agent and a catalyst, and a drug delivery system using the BAB-type tri-block copolymer.

The invention discloses a glucose group-terminated PLLA diblock copolymer material and a preparation method thereof, belonging to the technical field of high polymer materials. The preparation methodcomprises the following steps: firstly, subjecting PLLA and 1,2:5,6-di-O-isopropylidene-D-gulose (IPG) serving as raw materials to a reaction under the conditions that a molar ratio of IPG to PLLA isgreater than 4: 1, a polymerization pressure is 10-300 Pa, and a polymerization temperature is 160-200 DEG C; and carrying out a melt polymerization reaction for 4-12 hours to prepare a poly(L-lacticacid)-isopropylidene glucose diblock copolymer (PLLAIPG), and removing a hydroxyl protection group of the PLLAIPG to obtain the glucose group-terminated PLLA diblock copolymer (PLLAG). The PLLAG material has a melting temperature of about 150 DEG C and a crystallinity of about 50%, which are similar to those of PLLA, but the hydrophilicity of the PLLAG material is superior to the hydrophilicity ofPLLA; and the contact angle of the PLLAG material is about 65 degrees while the contact angle of PLLAG is 88 degrees.

The invention discloses a glucose group-terminated poly D-lactic acid diblock copolymer material and a preparation method thereof, and belongs to the technical field of high polymer materials. The preparation method comprises the steps: firstly, taking poly D-lactic acid (PDLA) and 1,2;5,6-oxo-diisopropylidene glucose (IPG) as raw materials; under the conditions that the molar ratio of IPG to PDLAis greater than 4:1, the polymerization pressure is 10-300 Pa and the polymerization temperature is 160-200 DEG C, carrying out melt polymerization reaction for 4-12 h to prepare a poly D-lactic acid-isopropylidene glucose diblock copolymer (PDLAIPG), and removing a hydroxyl protection group of the PDLAIPG to obtain a glucose group-terminated poly D-lactic acid diblock copolymer (PLDAG). The PLDAG material has a melting temperature of about 149 DEG C and a crystallinity of about 50%, which are similar to those of poly D-lactic acid, but the hydrophilicity of the copolymer material is superiorto that of poly D-lactic acid, the contact angle of the copolymer material is about 64 degrees, and the contact angle of poly D-lactic acid is 85 degrees.

The disclosed concept relates to multi-layer dielectric film with nano- or micro-structured block copolymers, such as, but not limited to, di-block copolymers and tri-block copolymers, and, more particularly, to capacitors constructed from the film. More particularly, the disclosed concept provides the ability to tune or control one or more characteristics of the dielectric film and capacitors formed therefrom, by selecting and combining blocks that exhibit different electrical and / or mechanical properties.

The invention relates to a nano drug of photoinduced release of nitric oxide anti-biofilm, and a preparation and application method. A synthesis method includes the following steps: (1) performing oxidation co-deposition on acetylglucosamine and dopamine, obtaining glucosamine through deacetylation, and preparing a cationic monosaccharide modified polydopamine nanomaterial (PDG); (2) using the reducibility of an orthophthalic bisphenol structure on the PDG to in situ reduce HAuCl4 into elemental gold nanoparticles, and synthesizing a glucosamine modified polydopamine@gold hybrid nanomaterial (PDG@Au); (3) blending an NO donor TCF and the PDG@Au in a glass sample bottle, and obtaining a PDG@Au-NO nanomaterial through magnetic stirring and centrifugal washing; and (4) modifying diblock copolymer p(AM-b-APBA) prepared from monomer N-3-acrylamide phenyl boric acid (APBA) and monomer4-acryloyl morpholine (AMP) through RAFT polymerization on a surface of the PDG@Au, and preparing PDG@Au / PBA. The nanomaterial obtained by the synthesis method has a good antibacterial effect and an effect of dissipating biofilm.

The invention discloses a degradable copolyester which is a random copolymer or a double-block copolymer composed of difficult-to-hydrolyze polyester fragments and easy-to-hydrolyze fragments or sites, wherein the number-average molecular weight of the copolyester is 30000 g / moL to 500000 g / moL; and the easy-to-hydrolyze fragments or sites are selected from polylactic acid with different chain segment lengths. The copolyester is high in molecular weight, free of environment-unfriendly chain extenders, good in mechanical strength and toughness, resistant to heat and good in processability, and can be independently used as plastic. In various natural environments such as water, soil, compost and the like, the copolyester can be completely degraded in the natural environments to form environment-pollution-free carbon dioxide and water. The invention also discloses a preparation method and application of the degradable copolyester.

The invention discloses a method for preparing a novel polyethylene glycol-poly gamma butyrolactone (PEG-PBL) di-block copolymer nano drug carrying microsphere. The provided PEG-PBL copolymer copolymer nano drug carrying microsphere has a small particle size, is narrowly distributed, has a high drug carrying capacity, can be slowly released for a long time, and can reduce the drug delivery frequency. In addition, according to results of biological evaluation, it is proved that the polyethylene glycol-poly gamma butyrolactone di-block copolymer nano drug carrying microsphere has excellent biocompatibility and anticancer activity. The provided novel polyethylene glycol-poly gamma butyrolactone di-block copolymer nano drug carrying microsphere has a simple preparation method, is easily produced on a large scale, and has broad application prospects in the field of drug slow release.

A method of controlling both alignment and registration (lateral position) of lamellae formed from self-assembly of block copolymers, the method comprising the steps of obtaining a substrate having an energetically neutral surface layer comprising a first topographic “phase pinning” pattern and a second topographic “guiding” pattern; obtaining a self-assembling di-block copolymer; coating the self-assembling di-block copolymer on the energetically neutral surface to obtain a coated substrate; and annealing the coated substrate to obtain micro-domains of the di-block copolymer.

The invention discloses an aminophenolate zinc complex containing pyridine rings, a preparation method of the complex and application of the complex to catalyzing lactone ring opening polymerization.The preparation method of the aminophenolate zinc complex containing pyridine rings comprises the following steps that a neutral ligand directly reacts with a zinc metal raw material compound in an organic medium; then, through the steps of filtering, concentration and recrystallization steps, a target compound is obtained. The aminophenolate zinc complex is an efficient lactone ring opening polymerization catalyst and can be used for catalyzing polymerization reaction of lactone such as lactide and caprolactone; a di-block copolymer can be obtained by catalyzing lactide and caprolactone copolymerization by a one-pot method. The aminophenolate zinc complex has the obvious advantages that the raw materials can be easily obtained; the synthesis route is simple; the product yield is high; high catalytic activity is realized; a high-molecular-weight polyester material can be obtained; the requirements of industrial department can be met. The structure formula is shown in description.

The invention discloses a tacrolimus loaded micelle and a preparation method and applications thereof. The micelle comprises tacrolimus and a di-block copolymer. The di-block copolymer is mPEG-b-P(LA-co-GA) or mPEG-b-PLA, the structure of the di-block polymer is represented by the formula (I) or the formula (II), n is a positive integer (10-100), x is a positive integer (10-300), and y is a positive integer (30-300). Di-block biodegradable high molecular segmented copolymers with different molecular weights are designed and taken as a carrier to load tacrolimus so as to prepare the tacrolimusloaded micelle, which has the advantages of uniform particle size, low polydispersity index (PDI=0.1), and good stability. Eye drops prepared from the micelle can well relieve the rejection reactionsafter corneal transplantation, and compared with tacrolimus eye drops (0.05%) used in clinic, the bioavailability is much better.

The invention belongs to the field of medicine, and specifically relates to a CP-iRGD polypeptide, iRGD-DOTAP-mPEG-PLA nanoparticles, and a drug-loading complex, a preparation method and applicationsthereof. The technical problem to be solved by the present invention is to provide a new modification way form modifying a mPEG-PLA diblock copolymer, wherein an amphiphilic mPEG-PLA diblock copolymeris modified with a positively charged amphiphilic substance DOTAP and a modified CP-iRGD polypeptide having tumor targeting effect, and a self-assembly method is used to prepare the novel degradablegene vector iRGD-DOTAP-mPEG-PLA nanoparticles, ie., iDPP nanoparticles, wherein the iRGD-DOTAP-mPEG-PLA nanoparticles have good DNA binding ability, can effectively introduce gene plasmid into tumor cells, and have advantages of high transfection rate, low cytotoxicity and the like.

The invention relates to crizotinib prodrug polymeric micelle co-loaded with a chemotherapeutic drug and a preparation method thereof, belongs to the field of a high molecular material and a new dosage form of a medicinal preparation, and particularly relates to crizotinib prodrug polymeric micelle co-loaded with a chemotherapeutic drug, which has an effect of reinforcing tumor immunogenicity, anda preparation method thereof. The prodrug polymeric micelle is characterized by being formed by firstly polymerizing a hydrophilic POEG block and hydrophobic crizotinib through a Reversible Addition-Fragmentation chain Transfer (RAFT) method to obtain an amphiphilic diblock copolymer and then physically loading the chemotherapeutic drug into the diblock copolymer to carry out self-assembling. According to the invention, a co-delivery mode of adopting conventional predrug polymer physical loading or adopting a polymer predrug to carry out self-assembling and physically loading another drug small molecules is broken through, and by a polymerization method using a drug as a monomer, high-efficiency co-loading of the combined drug and in-vivo accurate co-delivery are effectively implemented.