44 results about "L-Epicatechin" patented technology

Provided are a use of epicatechin or a legume extract containing epicatechin for preparing a composition for tranquilizing skin, and a skin itch treatment method comprising a step of applying a cosmetic composition to the skin of an individual causing itch, the cosmetic composition being the composition for tranquilizing skin.

The invention relates to the technical field of polymer degradable materials, in particular to a biodegradable material as well as a preparation method and application thereof. The material takes modified polylactic acid as a main body, and an antioxidant, a plasticizer, a flame retardant and an inorganic filler are used as auxiliary materials in parts by weight. The method is characterized in that lactic acid and an epicatechin imidazole ammonium chloride polymer are polymerized under the catalysis of stannous octoate, and an epicatechin bioactive group is introduced into a polylactic acid main chain in a chemical bonding manner, so that the biodegradation rate, the mechanical property and the thermal stability of the material are remarkably improved. Bioactive substances and ionic groups in the material promote microbial degradation, and the material can be completely decomposed in a compost environment in a short time; meanwhile, the strength, the toughness and the high-temperature processability of the polylactic acid are effectively improved through molecular-level enhancement and an ionic cross-linking effect. The material can be widely applied to the fields of disposable tableware, food packaging films, degradable agricultural mulching films and the like.

The present invention discloses a method for improving the quality of Millettia reticulata, belonging to the technical field of Millettia reticulata cultivation. It applies a growth regulator in combination with spectral lighting. The growth regulator is methyl jasmonate, with a concentration of 100 - 400 μmol / L. The LED light quality of the spectral lighting is red light and blue light, and the total photon flux density of red light and blue light is 200 μmol / m 2 / s, and the light quality ratio of red light to blue light is 2 - 5:1. The method of the present invention can effectively improve the growth of Millettia reticulata seedlings, significantly increase the contents of the active ingredients total flavonoids, catechins, epicatechins and gallocatechins, especially the improvement effect of catechins is the best. In an embodiment, compared with the blank group, the contents of total flavonoids, catechins, epicatechins and gallocatechins are significantly increased by 83.05%, 314.72%, 81.03% and 179.62% respectively, and the effect is remarkable.

The invention discloses a method for separating and extracting epicatechin, formononin and genistin from caulis spatholobi and application of the formononin, belongs to the technical field of natural product extraction and medical application, and relates to an efficient and controllable extraction process. According to the method, the three active ingredients of epicatechin, ononin and genitin can be enriched and purified at the same time from the caulis spatholobi, the potential medicinal value of ononin in gastric cancer treatment is further revealed, and a scientific basis is provided for deep development and comprehensive utilization of the caulis spatholobi.

The invention provides application of epicatechin in preparation of a medicine for resisting frog iridovirus. Related experiments prove that the epicatechin can efficiently prevent and control infection and transmission of the frog iridovirus, so that the harm of the frog iridovirus to healthy culture of frogs such as bullfrogs can be reduced to a great extent, and high-quality ecological culture and economic benefits of the frog culture industry are promoted.

The invention relates to efficient modified resin for adsorbing epicatechin. According to the method, alkalescent resin D301G is taken as a raw material, and chloromethylation is carried out to prepare the D301G-Cl resin. The preparation method comprises the following steps: adding D301G-Cl resin and N, N-dimethylformamide into a three-necked flask with a stirrer and a thermometer, sealing a cover, soaking, and adding NaCl, p-aminobenzene sulfonic acid and NaOH into the flask; stirring the mixed solution by using a stirrer, and reacting for a period of time at constant temperature; and after the reaction is finished, filtering by adopting a filter screen with a certain mesh number, and recycling filtrate. Repeatedly washing the resin with ethanol and distilled water until the added AgNO3 solution does not precipitate; the modified resin (D301G-SO3 <->) with the sulfonic acid group is obtained. The macroporous resin contains amino groups and sulfonic acid groups, so that the adsorption of epicatechin hydroxyl groups is further enhanced on the basis of benzene ring pi-pi adsorption. The adsorption capacity of the D301G-SO3-resin is larger than that of AB-8 under the condition that the pore volume is small, the adsorption effect of the D301G-SO3-resin on epicatechin is remarkably improved, the maximum adsorption capacity is improved by one time, the maximum adsorption capacity is kept within the PH range of 7-9, and the adsorption efficiency on the epicatechin is greatly improved.

Provided herein are process steps for the synthesis of (-)-epicatechin. The synthesis method provided by the invention is divided into two stages: (1) synthesizing an epoxide intermediate and (2) synthesizing the (-)-epicatechin.

This invention relates to the field of polymer degradable materials technology, specifically to a biodegradable material, its preparation method, and its applications. The material is based on modified polylactic acid (PLA), supplemented by antioxidants, plasticizers, flame retardants, and inorganic fillers in specific weight proportions. Its unique feature lies in the polymerization of lactic acid and epicatechin imidazole ammonium chloride polymer under stannous octoate catalysis, using chemical bonding to introduce the bioactive groups of epicatechin into the PLA backbone, significantly improving the material's biodegradation rate, mechanical properties, and thermal stability. The bioactive substances and ionic groups in this material promote microbial degradation, achieving complete decomposition in a composting environment within a short time. Simultaneously, through molecular-level reinforcement and ionic cross-linking effects, the strength, toughness, and high-temperature processing performance of PLA are effectively improved. This material can be widely used in disposable tableware, food packaging films, and biodegradable agricultural mulch films.

The invention discloses a low caffeine nerve stimulation tea wine based on litchi wood and sandalwood and a preparation process thereof, the wine is mainly prepared by blending litchi wood barrel aged tea wine and litchi wood / sandalwood barrel aged tea wine with different baking degrees, and the mass ratio of protocatechuic acid to catechin to epicatechin in the wine body is (0.15-0.28): 1: (0.15-0.25). The mass ratio of the protocatechuic acid to the alpha-santalol to the beta-santalol is 1: (0.4-0.6), the mass ratio of the quercetin to the gallic acid to the ferulic acid is (1.7-2.5): 1: (2.5-3.5), the mass ratio of the protocatechuic acid to the alpha-santalol is (1-2.5): 1, and the total content of the protocatechuic acid, the catechin, the epicatechin, the alpha-santalol, the beta-santalol, the quercetin, the gallic acid and the ferulic acid in the wine is 60-600mg / 100mL. By combining and matching the functional components in the wood and the proportion of the functional components, the antagonistic effect on caffeine nerve stimulation in the tea wine is achieved.

The invention relates to the field of preparation of starch nano-particles, and particularly provides pepper starch nano-particles loaded with epicatechin and a preparation method of the pepper starch nano-particles. According to the preparation method, pepper starch is used for loading epicatechin, and contrast experiments prove that the specific process combination (debranching, stirring and homogenizing) is crucial for realizing high encapsulation efficiency. The finally prepared pepper starch nanoparticles can significantly improve the entrapment efficiency of epicatechin. Therefore, the load efficiency is higher, the waste of active ingredients is lower, and the method has a remarkable industrial cost advantage.

The present invention discloses a quality detection method for a traditional Chinese medicine compound Qingkui Yuyang Decoction. The UPLC-Q-Exactive Orbitrap-MS / MS analysis method is used to qualitatively analyze the chemical components of the six medicinal materials in the Qingkui Yuyang Decoction, namely, coptis chinensis, frankincense, sanguisorba officinalis, indigo naturalis, catechu, and dragon's blood. Then, the high performance liquid chromatography method is used to determine the contents of epicatechin, catechin, rutin, coptisine, and berberine in the Qingkui Yuyang Decoction. The UPLC-Q-Exactive Orbitrap-MS / MS analysis method has the advantages of high resolution, good mass accuracy, and strong qualitative ability, and can perform extensive and accurate detection of the chemical components in complex traditional Chinese medicine compounds. The high performance liquid chromatography can provide detection results with high accuracy, high sensitivity, and good repeatability, is simple and easy to operate, and has passed methodological verification, with good linearity. The precision, stability, repeatability, and recovery rate all meet the requirements. The combination of qualitative and quantitative analysis lays the foundation for the establishment of the quality standard for Qingkui Yuyang Decoction.

The present disclosure is related to dietary supplements. For example, this disclosure relates to compositions that include, one or more agents that decrease the production of tumor necrosis factor-alpha (TNF-α), decrease the CCL2, and decrease the interleukin-1 beta (IL-1β) responsible for low grade chronic inflammation.In some embodiments, the composition comprises: epicatechin present in an amount of about 0.25% to about 1% w / w of the composition; EGCG present in an amount of about 0.01% to about 0.1% w / w of the composition; lycopene present in an amount of about 1% to about 3% w / w of the composition; quercetin present in an amount of about 0.1% to about 1% w / w of the composition; luteolin present in an amount of about 0.1% to about 1% w / w of the composition; vitamin A present in an amount of about 1% to about 7.5% w / w of the composition; vitamin C present in an amount of about 40% to about 77% w / w of the composition; and vitamin E present in an amount of about 15% to about 40% w / w of the composition. Such compositions are useful for improving LGCI by decreasing TNF-α, CCL2, and IL-1β concentration.

The application belongs to the technical field of natural fruit active substance detection, and discloses a method for simultaneously detecting the contents of multiple active components in green fruits based on HPLC, wherein the active components include seven main active components in green fruits, i.e., pyrogallol, gallic acid, epicatechin, ethyl gallate, p-coumaric acid, epigallocatechin and ellagic acid. The detection method established by the application is good and the instrument is precise, and the method has the technical advantages of good selectivity, high sensitivity and accuracy and reliability for detecting the contents of the main active components in green fruits, thereby providing a new analysis method and reliable basis for quality analysis and quality control of green fruits.

The invention belongs to the technical field of plant disease prevention and control, and particularly relates to application of epicatechin and protocatechuic acid in prevention and control of citrus huanglongbing. Through systematic experimental research and application verification, it is found that epicatechin and protocatechuic acid can remarkably inhibit the number of citrus huanglongbing pathogenic bacteria, have a good synergistic effect, can remarkably improve the overall health condition of citrus trees and have excellent application prospects and popularization value. As epicatechin and protocatechuic acid have the characteristics of being natural, environment-friendly and efficient, the epicatechin and protocatechuic acid show important application potential in the field of prevention and treatment of the citrus huanglongbing, and are expected to become novel key tools in the field. The discovery not only provides a new thought for green prevention and control of the citrus huanglongbing, but also provides powerful technical support for sustainable development of the global citrus industry, and is of great significance for guaranteeing stable development of the industry.

The invention discloses a preparation method and application of hempseed (-)-epicatechin-3-O-gallate, and belongs to the technical field of biology. According to the preparation method disclosed by the invention, the non-ester catechin and the ester-rich catechin are separated by adopting the mixed solvents of the ethanol, the methanol and the isopropanol, so that the extraction rate of the (-)-epicatechin-3-O-gallate can be improved (97% or above). Meanwhile, recrystallization is carried out by adopting organic solvents of methanol, normal propyl alcohol and isopropyl alcohol after extraction, so that the purity of the hempseed (-)-epicatechin-3-O-gallate can be improved (98% or above). The extracted epicatechin-3-O-gallate (ECG) is a natural antioxidant, has good biological activity, and has a good treatment effect on prevention and treatment of the hyperuricemia nephropathy.

The invention discloses an active composition for treating atopic dermatitis and application thereof, and belongs to the technical field of biological medicine. The (+)-catechin hydrate, the epicatechin, the chlorogenic acid and the amyrin in a specific proportion are compounded to serve as active ingredients, the multi-target and multi-channel synergistic interaction effect is achieved, and the effect of remarkably treating atopic dermatitis is achieved; besides, the components of the carrier are optimized, the stability, skin permeability and slow release performance of the active components are remarkably improved, percutaneous penetration and target site accumulation of the active components are enhanced, and therefore the local drug concentration and the curative effect durability are improved; the composition has the advantages that the composition can be rapidly formed at low temperature, the biological activity of the active ingredients is better, the composition can be processed and prepared into various local external dosage forms such as gel, cream, dressing and spray according to clinical requirements, the application is flexible, the adverse reaction possibly caused by long-term use of traditional hormone or chemical synthetic drugs is avoided, and the composition has a good industrial conversion prospect.

The present application relates to the field of preparation of starch nanoparticles, and specifically provides a kind of epicatechin loaded pepper starch nanoparticles and its preparation method.The preparation method is to use pepper starch to load epicatechin, and through comparative experiment, it is proved that the specific process combination (debranching, stirring, homogenization) of the present application is crucial to realize high encapsulation rate.The finally prepared pepper starch nanoparticles can significantly improve the encapsulation rate of epicatechin.This means higher loading efficiency and lower waste of active ingredients, with significant industrial cost advantage.

The invention relates to a composition comprising a mixture of catechin and / or epicatechin, safranal and crocetin in aglycone and / or glycosylated form. Such a composition can be used as a nutritional product or medicament and has a synergistic action for improving cognitive functions and / or executive functions in humans or animals.

Methods steps for the synthesis of (−)-epicatechin are provided herein. The synthetic methods are provided in two phases: (1) synthesis of epoxide intermediates and (2) synthesis of (−)-epicatechin.

The invention discloses application of hempseed (-)-epicatechin-3-O-gallate, and belongs to the technical field of biology. According to the invention, the EPI (-)-epicatechin-3-O-gallate extracted from the EPI is applied to the diabetic kidney diseases, so that the EPI can significantly reduce blood sugar and blood fat levels, improve pathological changes of the kidney of diabetic mice, delay senescence and fibrosis of renal tubular epithelial cells of the diabetic mice, improve the drug efficacy of DKD (Dikyl Ketene Dimer), and can be used for treating the diabetic kidney diseases. And reliable treatment targets and theoretical basis are provided for treating DKD by natural medicine monomer components.

The application discloses a phospholipid-epicatechin liposome and a preparation method and application thereof, and relates to the field of food preservation technology. The preparation method of the phospholipid-epicatechin liposome comprises the following steps: taking a functional phospholipid fraction as a membrane material, taking epicatechin as an active component, and preparing the phospholipid-epicatechin liposome by an ethanol injection-ultrasonic method; and the functional phospholipid fraction is prepared by taking low-value sturgeon caviar as raw material, extracting by chloroform-methanol and purifying by silica gel column chromatography. The phospholipid-epicatechin liposome provided by the application can be applied to sturgeon caviar preservation, can effectively delay product brightness attenuation, inhibit abnormal accumulation of volatile basic nitrogen and malondialdehyde, retard excessive degradation of protein, and maximally retain key functional fatty acids such as EPA and DHA in the caviar.

Method steps for the synthesis of (-)-epicatechin are provided herein. The synthesis method is provided in two steps: (1) synthesis of an epoxide intermediate, and (2) synthesis of (-)-epicatechin.

The present invention relates to the use of a mixture of molecules obtained from wine grapes and vaccinium angustifolium. The invention provides a method for preparing a mixture of molecules obtained from wine grapes and vaccinium angustifolium for use in healthy humans or healthy animals. The present invention relates to a mixture for use in a rapidly effective composition of a single dose taken on a non-repetitive basis to improve or maintain its performance for an exam or a test requiring sustained cognitive competence in healthy humans, said mixture comprising: at least 1% catechin and / or epicatechin, the present invention relates to a composition comprising a single dose of ferulic acid and resveratrol, said percentages giving, by weight relative to the total weight of the mixture, at least 5 ppm (parts per million in the mixture) of ferulic acid, and at least 200 ppm of resveratrol, said single dose being administered within 5 hours prior to the desired action.

The present application relates to the technical field of traditional Chinese medicine research, in particular to a chemical component analysis method of Rosa roxburghii tratt matcha tablets and a mechanism research method of the tablets in treating type 2 diabetes. The present application identifies active substances in the Rosa roxburghii tratt matcha tablets through liquid chromatography-mass spectrometry (LC-MS) analysis, and a total of 43 monomer substances are identified. The present application screens and obtains target points of the identified compounds through various databases, and obtains 21 core target points related to diabetes by combining network pharmacology methods, and determines 9 bioactive substances in the Rosa roxburghii tratt matcha tablets related to the core target points of diabetes, including catechin-(4α→8)-catechin, epicatechin-(4β→8)-catechin, and rose acid, etc., which provides a theoretical basis for the research and development of functional food for assisting in reducing blood sugar and provides a theoretical basis for deep processing products of Rosa roxburghii tratt.

The present application relates to: a composition for inhibiting bile salt hydrolase (BSH) comprising epicatechin as an active ingredient; a method for inhibiting bile salt hydrolase of an animal using same; and a use of catechin for inhibiting bile salt hydrolase.

The present application relates to the technical field of analytical detection, in particular to a molecular imprinting sensor for in-situ detection of epicatechin in plant leaves and a preparation and application method thereof.The present application utilizes a zeolite imidazolate framework-amide functionalized single-walled carbon nanotube composite material, amino-formyl imidazole modified reduced graphene, and a MIP film to be assembled layer by layer on the surface of an electrode, thereby preparing a molecular imprinting sensor for detecting epicatechin, and realizing high selectivity and high sensitivity detection of the target molecule epicatechin.This technology can effectively reduce the detection cost, simplify the operation process, and improve the performance of the sensor.Especially, the introduction of MIP enables the sensor to have the ability of in-situ detection and high-precision molecular recognition, and can realize rapid and reliable quantitative analysis in complex samples, thus having a wide application prospect.

One aspect of the present disclosure provides a skin-soothing composition including epicatechin or a soybean extract including epicatechin, as an active ingredient.

There has been need for tea beverages that maintain characteristics thereof while maintaining drinkability even with a low pH. One aspect of the present invention provides a beverage containing diacetyl and catechins, wherein the diacetyl content is at least 20 ppb and less than 10,000 ppb, the contained amount one or more types of catechins selected from epicatechin, catechin, epigallocatechin, gallocatechin, epicatechin gallate, catechin gallate, epigallocatechin gallate, and gallocatechin gallate is at least 1 ppm and less than 500 ppm, and the pH is 5 or lower.

This invention discloses a method for preparing lactoferrin-polyphenol nanocomposites with intestinal immune function. The method involves the following steps: First, lactoferrin is moderately hydrolyzed under the action of a complex protease to optimize its molecular structure. Then, it is compounded with water-soluble polyphenols (such as chlorogenic acid or epicatechin) using metal ion chelation technology, and Ca²⁺ is used to induce lactoferrin bridging and aggregation to form a complex. Next, ultrasonic homogenization is performed to further control the particle size, ensuring it is distributed within the range of 100-300 nm. The resulting complex is then concentrated by nanofiltration and electrostatic spray drying to obtain a structurally stable shell-core nanocomposite, which is then nitrogen-filled to prevent oxidation. The lactoferrin-polyphenol nanocomposite prepared by this invention not only exhibits good stability and intestinal immune-enhancing effects but also significant antibacterial activity, making it widely applicable in functional foods and nutritional supplements.

The application discloses a tea characteristic component composition for reducing acrylamide in Maillard reaction, and the composition is prepared by compounding at least three of five substances, i.e., epicatechin (EC), gallocatechin (GC), catechin gallate (CG), theabrine and theaflavine, and the compounded composition has the effect of reducing acrylamide, a by-product of Maillard reaction in food. In the composition of the application, the composition composed of epicatechin (EC), gallocatechin (GC), catechin gallate (CG) and theabrine has the best effect of reducing acrylamide, a by-product of Maillard reaction, and the reduction rate of acrylamide in a simulation system can be up to 75%. The composition of the application can be applied to baked food or fried food, especially baked food such as bread, cookie, potato chip and the like.