20 results about "L-Epicatechin" patented technology

The invention relates to efficient modified resin for adsorbing epicatechin. According to the method, alkalescent resin D301G is taken as a raw material, and chloromethylation is carried out to prepare the D301G-Cl resin. The preparation method comprises the following steps: adding D301G-Cl resin and N, N-dimethylformamide into a three-necked flask with a stirrer and a thermometer, sealing a cover, soaking, and adding NaCl, p-aminobenzene sulfonic acid and NaOH into the flask; stirring the mixed solution by using a stirrer, and reacting for a period of time at constant temperature; and after the reaction is finished, filtering by adopting a filter screen with a certain mesh number, and recycling filtrate. Repeatedly washing the resin with ethanol and distilled water until the added AgNO3 solution does not precipitate; the modified resin (D301G-SO3 <->) with the sulfonic acid group is obtained. The macroporous resin contains amino groups and sulfonic acid groups, so that the adsorption of epicatechin hydroxyl groups is further enhanced on the basis of benzene ring pi-pi adsorption. The adsorption capacity of the D301G-SO3-resin is larger than that of AB-8 under the condition that the pore volume is small, the adsorption effect of the D301G-SO3-resin on epicatechin is remarkably improved, the maximum adsorption capacity is improved by one time, the maximum adsorption capacity is kept within the PH range of 7-9, and the adsorption efficiency on the epicatechin is greatly improved.

This invention relates to the field of polymer degradable materials technology, specifically to a biodegradable material, its preparation method, and its applications. The material is based on modified polylactic acid (PLA), supplemented by antioxidants, plasticizers, flame retardants, and inorganic fillers in specific weight proportions. Its unique feature lies in the polymerization of lactic acid and epicatechin imidazole ammonium chloride polymer under stannous octoate catalysis, using chemical bonding to introduce the bioactive groups of epicatechin into the PLA backbone, significantly improving the material's biodegradation rate, mechanical properties, and thermal stability. The bioactive substances and ionic groups in this material promote microbial degradation, achieving complete decomposition in a composting environment within a short time. Simultaneously, through molecular-level reinforcement and ionic cross-linking effects, the strength, toughness, and high-temperature processing performance of PLA are effectively improved. This material can be widely used in disposable tableware, food packaging films, and biodegradable agricultural mulch films.

The invention belongs to the technical field of plant disease prevention and control, and particularly relates to application of epicatechin and protocatechuic acid in prevention and control of citrus huanglongbing. Through systematic experimental research and application verification, it is found that epicatechin and protocatechuic acid can remarkably inhibit the number of citrus huanglongbing pathogenic bacteria, have a good synergistic effect, can remarkably improve the overall health condition of citrus trees and have excellent application prospects and popularization value. As epicatechin and protocatechuic acid have the characteristics of being natural, environment-friendly and efficient, the epicatechin and protocatechuic acid show important application potential in the field of prevention and treatment of the citrus huanglongbing, and are expected to become novel key tools in the field. The discovery not only provides a new thought for green prevention and control of the citrus huanglongbing, but also provides powerful technical support for sustainable development of the global citrus industry, and is of great significance for guaranteeing stable development of the industry.

The invention discloses a preparation method and application of hempseed (-)-epicatechin-3-O-gallate, and belongs to the technical field of biology. According to the preparation method disclosed by the invention, the non-ester catechin and the ester-rich catechin are separated by adopting the mixed solvents of the ethanol, the methanol and the isopropanol, so that the extraction rate of the (-)-epicatechin-3-O-gallate can be improved (97% or above). Meanwhile, recrystallization is carried out by adopting organic solvents of methanol, normal propyl alcohol and isopropyl alcohol after extraction, so that the purity of the hempseed (-)-epicatechin-3-O-gallate can be improved (98% or above). The extracted epicatechin-3-O-gallate (ECG) is a natural antioxidant, has good biological activity, and has a good treatment effect on prevention and treatment of the hyperuricemia nephropathy.

The invention discloses an active composition for treating atopic dermatitis and application thereof, and belongs to the technical field of biological medicine. The (+)-catechin hydrate, the epicatechin, the chlorogenic acid and the amyrin in a specific proportion are compounded to serve as active ingredients, the multi-target and multi-channel synergistic interaction effect is achieved, and the effect of remarkably treating atopic dermatitis is achieved; besides, the components of the carrier are optimized, the stability, skin permeability and slow release performance of the active components are remarkably improved, percutaneous penetration and target site accumulation of the active components are enhanced, and therefore the local drug concentration and the curative effect durability are improved; the composition has the advantages that the composition can be rapidly formed at low temperature, the biological activity of the active ingredients is better, the composition can be processed and prepared into various local external dosage forms such as gel, cream, dressing and spray according to clinical requirements, the application is flexible, the adverse reaction possibly caused by long-term use of traditional hormone or chemical synthetic drugs is avoided, and the composition has a good industrial conversion prospect.

The present application relates to the field of preparation of starch nanoparticles, and specifically provides a kind of epicatechin loaded pepper starch nanoparticles and its preparation method.The preparation method is to use pepper starch to load epicatechin, and through comparative experiment, it is proved that the specific process combination (debranching, stirring, homogenization) of the present application is crucial to realize high encapsulation rate.The finally prepared pepper starch nanoparticles can significantly improve the encapsulation rate of epicatechin.This means higher loading efficiency and lower waste of active ingredients, with significant industrial cost advantage.

Methods steps for the synthesis of (−)-epicatechin are provided herein. The synthetic methods are provided in two phases: (1) synthesis of epoxide intermediates and (2) synthesis of (−)-epicatechin.

The application discloses a phospholipid-epicatechin liposome and a preparation method and application thereof, and relates to the field of food preservation technology. The preparation method of the phospholipid-epicatechin liposome comprises the following steps: taking a functional phospholipid fraction as a membrane material, taking epicatechin as an active component, and preparing the phospholipid-epicatechin liposome by an ethanol injection-ultrasonic method; and the functional phospholipid fraction is prepared by taking low-value sturgeon caviar as raw material, extracting by chloroform-methanol and purifying by silica gel column chromatography. The phospholipid-epicatechin liposome provided by the application can be applied to sturgeon caviar preservation, can effectively delay product brightness attenuation, inhibit abnormal accumulation of volatile basic nitrogen and malondialdehyde, retard excessive degradation of protein, and maximally retain key functional fatty acids such as EPA and DHA in the caviar.

Method steps for the synthesis of (-)-epicatechin are provided herein. The synthesis method is provided in two steps: (1) synthesis of an epoxide intermediate, and (2) synthesis of (-)-epicatechin.

The present application relates to the technical field of traditional Chinese medicine research, in particular to a chemical component analysis method of Rosa roxburghii tratt matcha tablets and a mechanism research method of the tablets in treating type 2 diabetes. The present application identifies active substances in the Rosa roxburghii tratt matcha tablets through liquid chromatography-mass spectrometry (LC-MS) analysis, and a total of 43 monomer substances are identified. The present application screens and obtains target points of the identified compounds through various databases, and obtains 21 core target points related to diabetes by combining network pharmacology methods, and determines 9 bioactive substances in the Rosa roxburghii tratt matcha tablets related to the core target points of diabetes, including catechin-(4α→8)-catechin, epicatechin-(4β→8)-catechin, and rose acid, etc., which provides a theoretical basis for the research and development of functional food for assisting in reducing blood sugar and provides a theoretical basis for deep processing products of Rosa roxburghii tratt.

There has been need for tea beverages that maintain characteristics thereof while maintaining drinkability even with a low pH. One aspect of the present invention provides a beverage containing diacetyl and catechins, wherein the diacetyl content is at least 20 ppb and less than 10,000 ppb, the contained amount one or more types of catechins selected from epicatechin, catechin, epigallocatechin, gallocatechin, epicatechin gallate, catechin gallate, epigallocatechin gallate, and gallocatechin gallate is at least 1 ppm and less than 500 ppm, and the pH is 5 or lower.

This invention discloses a method for preparing lactoferrin-polyphenol nanocomposites with intestinal immune function. The method involves the following steps: First, lactoferrin is moderately hydrolyzed under the action of a complex protease to optimize its molecular structure. Then, it is compounded with water-soluble polyphenols (such as chlorogenic acid or epicatechin) using metal ion chelation technology, and Ca²⁺ is used to induce lactoferrin bridging and aggregation to form a complex. Next, ultrasonic homogenization is performed to further control the particle size, ensuring it is distributed within the range of 100-300 nm. The resulting complex is then concentrated by nanofiltration and electrostatic spray drying to obtain a structurally stable shell-core nanocomposite, which is then nitrogen-filled to prevent oxidation. The lactoferrin-polyphenol nanocomposite prepared by this invention not only exhibits good stability and intestinal immune-enhancing effects but also significant antibacterial activity, making it widely applicable in functional foods and nutritional supplements.

The application discloses a tea characteristic component composition for reducing acrylamide in Maillard reaction, and the composition is prepared by compounding at least three of five substances, i.e., epicatechin (EC), gallocatechin (GC), catechin gallate (CG), theabrine and theaflavine, and the compounded composition has the effect of reducing acrylamide, a by-product of Maillard reaction in food. In the composition of the application, the composition composed of epicatechin (EC), gallocatechin (GC), catechin gallate (CG) and theabrine has the best effect of reducing acrylamide, a by-product of Maillard reaction, and the reduction rate of acrylamide in a simulation system can be up to 75%. The composition of the application can be applied to baked food or fried food, especially baked food such as bread, cookie, potato chip and the like.

The application discloses an active composition for treating atopic dermatitis and application thereof, and belongs to the technical field of biological medicine. The application uses a specific proportion of (+)-catechin hydrate, epicatechin, chlorogenic acid and coniferyl alcohol as active ingredients, so as to play a synergistic effect of multi-target and multi-pathway, and achieve the effect of treating atopic dermatitis. In addition, the composition of the carrier is optimized, the stability, skin permeability and slow-release performance of the active ingredients are improved, the transdermal penetration and target site accumulation of the active ingredients are enhanced, the local drug concentration and the persistence of the curative effect are improved, the active ingredients have better bioactivity under low temperature, various local external dosage forms such as gels, creams, dressings and sprays can be prepared according to the clinical needs, the application is flexible, the adverse reactions caused by long-term use of traditional hormone drugs or chemical synthetic drugs can be avoided, and the application has a good industrial transformation prospect.

This invention provides a method for synthesizing novel natural pigments using phenotypic catechins. Various epicatechins, epigallocatechins, epicatechin gallate esters, and epigallocatechin gallate esters are used as substrates. These are mixed and subjected to a non-enzymatic oxidation reaction under humid and hot conditions to generate a new class of tea pigment compounds. The non-enzymatic oxidation products of the phenotypic catechins are then concentrated under reduced pressure, freeze-dried, extracted, and purified by column chromatography to obtain dimeric catechin pigments. The six novel dimeric catechin pigments obtained by this invention are synthesized using a simple method. The six novel dimeric catechin pigments obtained according to the method of this invention are orange-yellow or orange-red amorphous powders with good color-adjusting capabilities, and can be applied to coloring tea beverages and new-style tea drinks. The discovery of this type of natural pigment contributes to the research on coloring substances during the thermal processing of tea, the improvement of tea liquor color quality, and the development and application in the field of food coloring.

The application relates to the field of plant extraction, and particularly discloses a green tea tea polyphenol extraction method, which comprises the following steps: S1, macroporous resin separation is adopted after green tea raw materials are washed with acid water and then eluted with ethanol to prepare tea polyphenol extract; S2, the prepared tea polyphenol extract is first passed through a cellulose column filled with cellulose filler prepared by taking epicatechin as a template agent molecule, then eluted with ethyl propionate to prepare an EC extract; and S3, the tea polyphenol extract after passing through the cellulose column is passed through a modified PCL-PHEMA copolymer resin column containing an ether bond, then eluted with an ethanol solution to prepare an EGCG extract. The application has the characteristics of realizing green tea tea polyphenol extraction and further realizing the separation and extraction of EGCG and EC.

The application provides a hawthorn condensed tannin polymer and a preparation method and application thereof. The hawthorn condensed tannin polymer is extracted from hawthorn pulp, and the hawthorn condensed tannin polymer comprises a mixture of dimers, trimers, tetramers, pentamers, hexamers, heptamers, octamers, nonamers, decamers, undecamers, dodecamers, tridecamers, tetradecamers, pentadecamers, hexadecamers, heptadecamers and octadecamers of epicatechin shown in formula (I). Wherein, n is a positive integer between 2 and 18, and at least one of the dimers, trimers, tetramers, pentamers, hexamers, heptamers, octamers, nonamers, decamers, undecamers, dodecamers, tridecamers, tetradecamers, pentadecamers, hexadecamers, heptadecamers and octadecamers comprises a B-type procyanidin polymer obtained by connecting epicatechin structural units through C4-C8 or C4-C6.

The invention relates to the technical field of seasoning sauces, in particular to a sauce residue sauce and a preparation method thereof. The soy sauce residue sauce comprises edible soybean oil, soy sauce residues, first water, edible salt, glutinous rice flour, white granulated sugar and a compound antioxidant emulsion; the compound antioxidant emulsion comprises epicatechin, vitamin E, an emulsifier, a chelating agent, a pH regulator and second water; the epicatechin accounts for 0.05%-0.15% of the total weight of the sauce residue sauce material; the vitamin E accounts for 0.01%-0.03% of the total weight of the sauce residue sauce; the chelating agent accounts for 0.025%-0.075% of the total weight of the sauce residue sauce material. The sauce residue sauce is prepared from the sauce residues, the original sauce flavor and nutritional quality of the sauce residues are reserved, and the sauce residue sauce does not have burnt taste.

The invention discloses an application of a pyracantha fortuneana fruit extract in prevention and treatment of ulcerative colitis, and relates to the technical field of food medicines. The main components of the pyracantha fortuneana fruit extract comprise total flavonoids, total polyphenols and total triterpenes. Wherein the total flavonoids and the total polyphenols comprise hyperoside, rutin, isoquercitrin and epicatechin, and the total triterpenes comprise jujubogenin and the like. Functional food, health care products, medicines and other products prepared from the pyracantha fortuneana fruit extract can reduce the disease activity index, increase the colon length, reduce the abnormally-increased pro-inflammatory cytokine TNF-alpha content in serum, improve the glutathione peroxidase activity and achieve prevention and treatment of ulcerative colitis. Therefore, the pyracantha fortuneana fruit extract disclosed by the invention can be used as a raw material for preparing foods and medicines for preventing and treating ulcerative colitis.

This invention relates to the field of separation and purification technology, and in particular to a method for extracting and separating five compounds from the pomace of red bean and blueberry. This invention develops a microwave-ultrasound synergistic enhanced extraction coupled with carbon dioxide gas-responsive in-situ eutectic solvent targeted extraction technology, combined with macroporous resin enrichment and high-speed countercurrent chromatography separation technology, achieving efficient extraction of five monomeric components: epicatechin, astragaloside, quercetin, kaempferol, and ursolic acid. This process significantly reduces time consumption, energy consumption, and environmental pollution, providing technical support for the large-scale industrial production of red bean and blueberry resources for high-value utilization.