A nourishing health wine containing velvet antler blood and Maca and a preparation method thereof, which is characterized in that it comprises the following steps: (1) preparing materials: fresh velvet antler blood, Maca powder, yam, wolfberry, jujube, vinegar tortoise shell, base wine, Water, mixed enzyme preparation; (2) Enzymolysis of velvet antler blood: Enzymolysis uses mixed enzyme preparation, and the filtrate is collected for later use; (3) Raw materials are extracted by conventional leaching or percolation of base wine; (4) Preparation and aging. A nourishing health wine containing deer antler blood and Maca prepared by the above method. The process of the present invention improves the nutrition of velvet antler blood wine and the utilization value of active ingredients, preserves the active substances and active ingredients, can be absorbed by the human body in a full, balanced, and rapid manner, has significant sexual improvement functions, regulates endocrine, enhances immunity, and relieves fatigue and other health benefits.