The invention discloses an online multi-fluorination system, and relates to the technical field of fluorination reaction. The online multi-fluorination system comprises a filtration and purification device, an auxiliary cooling device, a shell, a water storage tank and a box, the outer surface of one side of the shell is fixedly connected with a feeding hopper, a third valve is arranged on the feeding hopper, the bottom of the shell is fixedly connected with a discharging pipe, a second valve is arranged on the discharging pipe, the inner walls of two sides of the shell are fixedly connected with connecting supports, the shell is fixedly connected with an air distribution plate through the connecting supports, one side of the shell is fixedly connected with an air inlet pipe, a one-way valve is arranged on the air inlet pipe, one end of the air inlet pipe penetrates the inside of the shell and is communicated with the inside of the air distribution plate, a partition plate is fixedly mounted on the inner wall of the shell, and a second rotating rod is rotatably mounted at the inner bottom of the shell. The online multi-fluorination system is reasonable in design and compact in structure, potential safety hazards can be reduced, health security of workers is improved, and environmental pollution is reduced.