The invention relates to a vacuum prepressing method of a sand-free cushion layer of a secondary circulation line system. In the method, the steps of superficial layer vacuum quick solidification, superficial layer vacuum secondary solidification and impacting compaction are used for prepressing, and the method specifically comprises the following steps of: distributing geotextile, a vertical plastic drainage short plate, a transverse plastic drainage short plate, a main drainage pipe and a secondary drainage pipe, wherein a vacuum film, a side ditch pressing film and a vacuum pump are arranged on the geotextile; paving a movable track and the vertical plastic drainage short plate; impacting and pressing a slag layer by using an impacting compactor, and the like. The invention overcomes the defects of high water content, low bearing capacity, difficult construction, and the like of vacuum prepressing soft foundation treatment and the defects of high expense, large repeated workload, long construction period, and the like of other methods. The invention has the advantages of strong bearing capacity, relatively simple construction, low expense, reduced workload, short construction period and obvious vacuum prepressing side sealing effect.