The invention discloses an isolongifolenone sun-blocking and mosquito-repelling cream. The isolongifolenone sun-blocking and mosquito-repelling cream comprises hexadecyl alcohol, octadecyl alcohol or eicosyl alcohol, hexadecyl glucoside, octadecyl glucoside or eicosyl glucoside, glyceryl monostearate, PEG-100 stearate, iso-octyl p-methoxycinnamate, octyl salicylate, isolongifolenone, methylparaben, ethylparaben, carbonic ester polymer, deionized water, xanthan gum, glycerol, polyacrylate-13, polyisobutene, polysorbate-20, citronella, eucalyptus essential oil, lavender essential oil and methylisothiazolinone. The cream has the double functions of repelling mosquito and blocking sun.