The invention relates to a satellite signal simulation technology and a virtual instrument technology, and discloses a housekeeping software simulation test system based on technology of a virtual instrument. The housekeeping software simulation test system comprises an industrial personal computer, an analog/digital signal input and output card, a serial port card, a CAN (Controller Area Network) bus card, and an FPGA (Field Programmable Gate Array) high-speed transmission card, wherein the industrial personal computer is connected with the cards, and the cards are connected with a housekeeping computer. The simulation test system functionally comprises a satellite separation module, a direct remote control module, an analog quantity telemetering module, a remote control digital input module, a telemetering reception and analysis module, a programmable command receiving module, a GPS (Global Position System) second signal module, a time reference module, a CAN data simulation module, a data transmission module and a serial port communication module. The housekeeping software simulation test system is formed by frame type hardware, and is programmed by the flexible software modules. Compared with the prior art, the housekeeping software simulation test system has the beneficial effects of being simple in structure, convenient to operate, short in development period, being widely suitable for various types of housekeeping software, and meeting flexibly-changed dynamic tests and nonstandard signal tests.