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Multi-modal system for detection and control of changes in brain state

ActiveUS7204833B1Increase temporo-spatial resolutionWithout of complications and without in performanceElectroencephalographyInternal electrodesBrain stateElectrical stimulations
A multi-purpose device mechanism for sensing and control of changes in brain state includes a shaft portion and extendible elements structured for insertion into target tissue of the brain of a subject patient, cooling means configured to operatively apply cooling therapy to the target tissue, stimulation means having at least one electrical contact structured to operatively apply electrical stimulation therapy to the target tissue, sensing means including at least one sensor monitoring a biological signal of the subject patient, control means responsive to the sensing means wherein the control means is structured to, in response to signals from the sensing means that indicate the presence of a pre-determined physiological condition or occurrence of an undesirable state change, automatically cause the cooling means and / or the stimulation means to initiate or terminate the cooling therapy and / or the electrical stimulation therapy respectively and an energy source for powering the various components of the multi-purpose device mechanism. A modified embodiment includes a least one spiral conduit and at least one return conduit for cycling coolant or refrigerant to and from the shaft portion and an external reservoir. Another modified embodiment includes pressurizing means for extending at least one extendable tube into brain tissue surrounding the shaft portion.
Owner:FLINT HILLS SCI L L C

Intravenous immunoglobulin composition

A method for preparing a concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, comprising: (a) selecting a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism; (b) determining the level of specific antibodies immunoreactive with the pathogenic microorganism in a blood or blood component of the individuals to identify very high titre individuals having a very high titre of the specific antibodies; (c) combining blood or blood components comprising immunoglobulins from the very high titre individuals; and (d) purifying and/or concentrating the product of step (c), thereby obtaining a concentrated immunoglobulin composition. Also disclosed is a concentrated immunoglobulin composition comprising specific antibodies immunoreactive with a pathogenic microorganism, characterized in that the titre of specific antibodies of the composition is at least 5 times higher than the average titre of specific antibodies of a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates, and is therefore suitable for both iv and im administration. In a preferred embodiment, the pathogenic microorganism is smallpox virus or vaccinia virus.
Owner:OMRIX BIOPHARM

Low pressure saturated steam cleaning assembly with chemical delivery system

The present invention provides a steam cleaning system comprising a housing and a steam generating system for producing a low pressure, superheated saturated steam. A steam dispensing system comprising a water reservoir and a pump feeding the water into a steam producing boiler, is coupled thereto for dispensing the steam from the system to at least one first outlet port. A cleaning solution dispensing system is provided, having at least one reservoir for a cleaning solution, and a pump system for dispensing a predetermined amount of a cleaning solution from said at least one reservoir to at least one second outlet port. The at least one first and second outlet ports are positioned adjacent one another, such that a mixture of cleaning solution and saturated steam at a low pressure and low volume of steam and cleaning solution is dispensed from the system. The present invention is particularly suited to clean objects off the floor, vertical surfaces such as glass, and small areas of floor. Because of the small volume of water and chemicals used, it can be used indoors, as well as mounted on mobile platforms such as trucks, buggies, utility vehicles, automatic floor scrubbers or the like. The system also provides for cleaning of roads, sidewalks, exterior structures, or for spot cleaning or cleaning of surfaces in difficult environments. The low pressure, superheated, saturated steam cleaning assembly of the present invention provides low pressure (10 Bar) operation, and relies upon superheated steam temperatures coupled with environmentally friendly chemicals as an abrasive force, thus avoiding any collateral damage usually caused by the high pressure output. The present invention only applies 3 to 10 gallons of water an hour, depending on the size of the machine, while a conventional high-pressure washer / steamer will use 240 gallons per hour.
Owner:LEVY MOISE MAURICE

Device for collection and assay of oral fluids

A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said oral cavity; and (c) determining the presence or absence of at least one analyte. The assay device used in the method comprises: (i) an assay portion housing an immunochrornatographic lateral flow assay strip, the lateral flow assay strip containing at least one reagent selected from an antigen and an antibody that is used to detect one of the presence or absence of at least one analyte in a fluid; (ii) a neck portion extending from the assay portion, the neck portion forming a channel for delivery of fluid to said assay strip and the channel being defined by a first, narrow part proximal to the assay portion and a second part including an opening for receiving the oral fluid, wherein the second part includes a channel width that is substantially wider than the channel width at the narrow end; (iii) a collection strip in fluid communication with the lateral flow assay strip, the collection strip having a first portion disposed within the channel and a second portion protruding outwardly from the neck portion opening; and (iv) a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip.
Owner:ORASURE TECHNOLOGIES

Device for collection and assay of oral fluids

A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and / or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.
Owner:ORASURE TECHNOLOGIES

Device for collection and assay of oral fluids

A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and / or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.
Owner:ORASURE TECHNOLOGIES

Quaternary array micro-electromechanical system (MEMS) vector hydrophone microstructure

The invention provides a quaternary array micro-electromechanical system (MEMS) vector hydrophone microstructure. The quaternary array MEMS vector hydrophone microstructure comprises a square substrate, wherein four cross-shaped cantilever beams are etched on the square substrate, a minitype cylindrical object is fixed in the center of each cross-shaped cantilever beam, and voltage dependent resistors are arranged on the cross-shaped cantilever beams. Included angles between the four cross-shaped cantilever beams and the square substrate are different with each other and are respectively 0 degree, 30 degrees, 45 degrees and 60 degrees. The quaternary array MEMS vector hydrophone microstructure is made through the MEMS technology and has the advantages of being highly sensitive, low in energy consumption and micro in size. Compared with the single vector hydrophone, a hydrophone made of the quaternary array MEMS vector hydrophone microstructure is high in directional accuracy, strong in space resolution ratio power and capable of solving the problem of port and starboard ambiguity. Compared with the traditional hydrophone array, the size of the array of the quaternary array MEMS vector hydrophone microstructure is greatly reduced. The quaternary array MEMS vector hydrophone microstructure is integrally formed through the MEMS technology, high consistency exists among array elements, and burden on calculation of sequential arithmetic is lightened.
Owner:ZHONGBEI UNIV

Stereoscopic lens manufacturing method

The invention discloses a stereoscopic lens manufacturing method, in which a stereoscopic lens material with adjustable curvature radius and focal distance under the condition of a fixed spacing is produced through combination of a mould head and a pair of moulds. The stereoscopic lens manufacturing method comprises a device preparing step and a stereoscopic lens material producing step, wherein the device preparing step comprises the following substeps: preparing the mould head for extruding molten plastic, manufacturing aspheric stereoscopic lens moulds for extruding and moulding a lens, and manufacturing a polishing roller for polishing the other surface of the lens material; the stereoscopic lens material producing step comprises the following substeps: adjusting the fitting degree of the moulds and the molten plastic, adjusting the extruding amount, the depositing amount and the producing speed of the mould head, extruding one surface of the plastic by using the aspheric stereoscopic lens moulds so as to form the front surface of the stereoscopic lens material, and polishing the other surface of the plastic by using the polishing roller so as to form the back surface of the stereoscopic lens material, by the stereoscopic lens manufacturing method, the stereoscopic lens material which has the same lens spacing, but has different curvature radiuses and corresponding focal distances.
Owner:SHANGHAI CAICHENG NEW MATERIAL TECH CO LTD
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