The application provides a safe torque off (STO) control circuit and system. The STO control circuit comprises a signal conversion circuit, a first photocoupling circuit, a second photocoupling circuit, a first NOT gate, a second NOT gate, a third NOT gate, a fourth NOT gate, a first RC filter circuit and a second RC filter circuit, wherein the first photocoupling circuit comprises a first resistor, a second resistor, a third resistor, a first capacitor, a second capacitor, a first diode, a second diode, a third diode, a fourth diode, a first voltage stabilization diode and a first isolation photocoupler, and the second photocoupling circuit comprises a fourth resistor, a fifth resistor, a sixth resistor, a third capacitor, a fourth capacitor, a fifth diode, a sixth diode, a seventh diode, an eighth diode, a second voltage stabilization diode and a second isolation photocoupler. In the application, the STO control circuit provided by the invention is used for achieving an STO function and circuit self-detection.