An anti-pilling wool fabric includes 100% merino superfine wool, Sunn crotataria fiber, cashmere, milk fiber, acrylic fiber, modal fiber, combed cotton, and real silk. The wool fabric is blended by various fibers, and uniqueness of various fibers can be stuck out through reasonable fiber composition; the advantages of various fibers are integrated to the wool fabric, the wool fabric has a smooth hand feeling of the real silk fiber, and excellent heat retention property and water absorption capability, shows a style of softness with toughness, brightness, and colorfulness, has the characters of smoothness and good overhanging feel of the milk fiber, and has moisturizing factors which can achieve comfort of wearing; the cashmere can allow abundant suede of fabric and smooth hand feeling; the modal fiber has excellent elastic and toughness, and then end-down phenomenon can be reduced during processing; fresh bright color can kept after multi-time washing due to excellent dyeing property; the wool fabric has good stability of shape and size, has natural wrinkle resistance, can prevent pilling, and has soft sweat inhibition functions.