The invention relates to a special integrated cultivation mode which combines a complete nutrient solution and an organic substrate for a summer squash. The special integrated cultivation mode comprises the steps that organic waste, such as crop straws, waste residues after edible fungi cultivation, excrement of animals and the like, is subjected to innocent treatment as a culture substrate for the summer squash instead of soil; and a water soluble fertilizer is used for producing the complete nutrient solution according to a nutrient element absorption ratio of the summer squash, and water and nutrient elements are supplied to the root system area of the summer squash in a manner of integration of water and fertilizer. The cultivation mode provided by the invention is adopted to plant the summer squash, and has the characteristics of safety in fertilizer application, water saving, labor saving, low cost, easiness in obtaining of raw materials of the substrate, high fertilizer and water utilization ratio, prevention of soil-borne diseases, and the like; compared with planting in common soil, the summer squash produced by the technical mode provided by the invention has the characteristics of low abortive fruit ratio, high yield, fine flesh, good taste, abundant nutrition, low pesticide residue, neat fruit twig, few malformed fruits, high commodity rate and the like; summer squash with high yield and high quality can be produced in places, such as severe saline-alkali soil, mountain ridge poor land, abandoned mining lands and the like where normal agricultural production cannot be performed.