The invention discloses a prestressed concrete superimposed sheet with steel trusses and a manufacturing method, and belongs to the technical field of architectural engineering. The prestressed concrete superimposed sheet structurally comprises prefabricated bottom plates, transverse steel bars and a superimposed layer, two sides faces, in the length direction, of each prefabricated bottom plate are inclined faces, a wedge-shaped edge joint is formed between every two adjacent prefabricated bottom plates, the wedge-shaped edge joints are filled with high-strength grouting materials, longitudinal prestress steel bars are distributed in the prefabricated bottom plates in the length direction, and the transverse distribution steel bars are arranged in the width direction. The upper portion of each prefabricated bottom plate is provided with at least one steel truss in the length direction, the transverse steel bars are arranged below the steel trusses in the width direction of the prefabricated bottom plates in a penetrating mode, the prefabricated bottom plates can be connected together, the superimposed layer is poured to the prefabricated bottom plates, and superimposed layer transverse steel bars and superimposed layer longitudinal steel bars are arranged in the superimposed layer. The prestressed concrete superimposed sheet has the advantages of being good in overall stress performance, large in application span, excellent in fireproof effect and high in factory production efficiency, enabling site operation to be easy and convenient and the like.