The invention relates to an indobufen pharmaceutical composition and a quality control method thereof. Specifically, the indobufen pharmaceutical composition of the present invention includes: 200 parts by weight of indobufen, 30-50 parts by weight of sugar diluent, 15-40 parts by weight of cellulose diluent, 5-15 parts by weight of disintegrant 3-8 parts by weight of binder, 1-5 parts by weight of glidant, and 1-5 parts by weight of lubricant. The sugar diluent is selected from the group consisting of mannitol, sucrose, lactose, fructose, glucose, sorbitol, hydrates thereof, and combinations thereof. The invention also relates to the preparation method of the composition, its quality control method and pharmaceutical application. The indobufen pharmaceutical composition of the present invention can be used for arteriosclerotic ischemic cardiovascular disease, ischemic cerebrovascular disease and peripheral arterial disease, dyslipidemia, venous thrombosis and diabetes, and can be used for preventing thrombosis during extracorporeal circulation operation Formed, the pharmaceutical composition exhibits excellent effects as described in the instructions.