The invention relates to a hollow bias structure of a wrist of an industrial robot. The hollow bias structure comprises a tail end output assembly, a first inner sheath, a sixth-axis wrist body, a first sixth-axis transition transmission assembly, a fifth-axis output assembly, a fifth-axis crossed roller bearing locking flange, a fourth-axis wrist body, a fifth-axis transition transmission assembly, a second sixth-axis transition transmission assembly, a fourth-axis output assembly, a first wrist connecting piece, a second wrist connecting piece, a fourth-axis input assembly, a fifth-axis input assembly, a sixth-axis input assembly, a second inner sheath, a first O-type sealing ring, a third inner sheath, a first O-type sealing ring, a fourth inner sheath and a second O-type sealing ring. The left side of the fourth inner sheath is sleeved with the second sixth-axis transition transmission assembly, and the right side of the fourth inner sheath is sleeved with the second wrist connecting piece. A servo motor is used for controlling, the wrist is driven to run through a speed reducer and a series of transmission manners, a fifth axis can rotate without limitations, the takt can be increased, efficiency can be improved, and the requirements of the spraying technology can be met.