The invention belongs to the technical field of sewage automatic treatment, and discloses a sewage treatment automation operating system implemented by utilizing a statistical modeling technology. The sewage treatment automation operating system comprises an integrated module, an early-warning module, a USAOS system, a communication module, a Web service system, a reporting module, a database system and a daily management module, wherein the integrated module is used for receiving and issuing instructions among an anaerobic module, a facultative module, an aerobic module, a sludge module, a dephosphorization module and a denitrification module, and the integrated module is connected with the early-warning module; and the integrated module sends code processing data to the USAOS system, the USAOS system returns a scheduling strategy to the integrated module at the same time, the USAOS system can further read alarming and early-warning information, the USAOS system issues an instruction to the daily management module according to the information, and the daily management module exerts the information on equipment. The sewage treatment automation operating system can achieve unattended operation, adjusts sewage flow and equipment operating parameters in a fully-automatic manner, sends out early warning, and can realize remote intervention and diagnosis.