20 results about "Brain spinal cord" patented technology

The invention relates to the field of closed-loop nerve regulation and function reconstruction, and discloses a closed-loop brain-spinal cord interface upper limb grasping function reconstruction method and system based on multi-modal biofeedback. According to the method, at least three kinds of feedback information such as joint angles, grabbing force and electromyographic signals are synchronously collected, and a comprehensive actual motion state is generated through weighted fusion; according to an error vector between an expected state and an actual state, a hierarchical adjustment strategy is creatively adopted to carry out differentiation and adaptive adjustment on parameters such as stimulation current intensity, frequency and pulse width; and fatigue indexes are calculated based on myoelectricity frequency domain characteristics (such as median frequency and average power frequency), and prospective intervention is carried out by superimposing a fatigue compensation strategy. The method effectively solves the problems that an existing system is low in control precision, insufficient in single feedback dimension information and insufficient in continuous motion ability, and the precision, adaptability and long-term stability of motion control are remarkably improved.

This invention involves, among other things, elements that stimulate an immune response. Which includes: a) one or more antigens of Avibacterium paragallinarum and One or more antigens of avian brain and spinal cord rhizomatous virus and one antigen. or more of avian porcine ... Furthermore, this invention relates to a method for immunizing animals which includes administration. The animal drug contains components that stimulate the immune response of this invention; moreover, This invention relates to a method of treating or preventing clinical signs caused by Avibactericum. Paragallinarum, a viral infection that causes encephalitis and spinal cord inflammation in birds and avian pox virus in animals. Essential, a method that involves administering medication to animals in effective dosages as a form of treatment. The components that stimulate an immune response are consistent with this invention;

Embodiments of the present application disclose a brain-spinal cord interface system. The system can include a first acquisition module, a decoding module, a conversion module, and a stimulation module. The first acquisition module is configured to acquire neural signals of a brain of a target subject to obtain target neural signals representing a movement intention of the target subject. The decoding module is configured to decode the target neural signals to obtain the movement intention. The conversion module is configured to convert the movement intention into target ultrasound stimulation parameters. The stimulation module is configured to stimulate a spinal cord of the target subject based on the target ultrasound stimulation parameters. The technical solution of the embodiments of the present application can better reconstruct the functional connection between the brain and the spinal cord.

Implantable devices and / or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices / sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and / or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

The present invention relates to a neuromodulation / neurostimulation system (100) for restoring motor function of an upper limb and / or a lower limb of a patient (P) suffering from spinal cord injury (SCI) and / or other neurological conditions and promoting neurological restoration, the system (100) comprising: a processing unit (10) configured and adapted to provide stimulation commands; an implantable or external stimulation unit (12) configured and adapted to deliver neuromodulation therapy, in particular electrical epidural stimulation (EES), to the dorsal root of the spinal cord (SC) of the patient (P); at least one implantable or external pulse generator (14), the at least one implantable or external pulse generator being operatively connected to the stimulation unit (12); an implantable neural sensor (16), the implantable neural sensor comprising an electronic component configured and adapted to detect a cerebral electrocorticogram (ECoG) signal representing a motor intent of the patient (P) from a sensory motor cortex (C) of the patient (P), wherein the processing unit (10), the stimulation unit (12) and the implantable neural sensor (16) are operatively connected to define a cerebrospinal cord interface (BSI), and wherein the processing unit (10) is configured and adapted to: preferably collect the ECoG signals from the sensory motor cortex (C) in real time and decode the ECoG signals into corresponding motor intent of the patient (P); the decoded motion intent is converted, preferably in real time, into a corresponding stimulation command, and the stimulation command is forwarded, preferably in real time, to the at least one pulse generator (14).

The invention discloses an efficient blood brain barrier crossing adeno-associated virus mutant and application, and relates to the technical field of biological medicine. A587Q588 in the amino acid of the AAV9 serotype capsid protein is replaced by a heterologous peptide; the heterologous peptide is a polypeptide consisting of any one of amino acid sequences in DGTIQAPFR (Databine Glycine Triphosphate Quantitative Amplified Polypeptide Receptor) or DGTTFTPPR ( The infection efficiency, mRNA (messenger ribonucleic acid) and protein expression of the SG302 and the SG303 on brain, spinal cord and thalamic neurons of a mouse are obviously higher than those of AAV9, and the infection capacity on the liver is obviously lower than that of the AAV9. The SG302 and the SG303 are serotype mutants with good specificity for a nervous system, the high infection efficiency can reduce the administration dosage, and the low hepatotrophy characteristic can improve the safety performance.

Ventricular catheters and their methods of use are disclosed. In some embodiments, the disclosed ventricular catheters may reduce, or substantially prevent, obstruction of the catheter by astrocytes or other brain tissue due to adhesion and / or growth within the catheter. For example, in some embodiments, the holes and internal lumen of a ventricular catheter may be constructed such that the wall shear stresses applied within the holes and internal lumen of the catheter are greater than a threshold shear stress to prevent cell adhesion and growth within the catheter.

The application discloses a waterproof and breathable type brain and spinal cord nerve injury wound protection dressing, which is sequentially stacked and arranged from inside to outside as a wound adhesion inner layer, a functional sustained-release middle layer and a waterproof and breathable outer layer; the three-layer synergistic dressing structure of the wound adhesion inner layer, the functional sustained-release middle layer and the waterproof and breathable outer layer is constructed, waterproof sealing and the dynamic adaptation of the air permeability performance of the brain and spinal cord nerve injury wound are realized, the target anti-scar polypeptide is covalently bonded on the inner layer, the effective inhibition of excessive scar hyperplasia and neuroma formation is realized, the matching regulation of the gradient degradation drug-loaded microsphere system and the air permeation pore size of the middle layer is realized, the accurate release of active factors in the whole cycle of nerve repair is realized, the long-acting waterproof and breathable protection in a dynamic scene is realized through the design of the outer layer of super-hydrophobic nanofiber membrane, the risk of postoperative complications is reduced, and the integration and synergy of the physical protection of the wound and the nerve function repair are realized.

The invention belongs to the technical field of experimental devices, and provides a fixing device for a brain-spinal cord sample of a mouse. The device comprises a base, a brain fixing groove and a spinal cord fixing groove, wherein the brain fixing groove and the spinal cord fixing groove are formed in the base and are communicated; the brain fixing groove is a bionic groove matched with the anatomical contour of the lateral hemisphere of the mouse brain and used for containing the lateral hemisphere of the mouse brain and exposing the tail end of the brainstem. The spinal cord fixing groove is a spiral bionic groove matched with the side dissection outline of the mouse spinal cord and used for containing the side face of the mouse spinal cord and enabling the spinal cord and the tail end of the brainstem to keep a natural connection angle. According to the invention, through the design of the bionic grooves and the buckles, each sample is ensured to be fixed in the same form; the structure of the mold limits the coiling path of the spinal cord, so that the embedding length becomes controllable and repeatable; through the preset coiling path and the buckle, the spinal cord is stabilized in the preset direction and prevented from being twisted, and the axon tracking accuracy is guaranteed.

The invention belongs to the technical field of experimental devices, and provides a batch processing system and method for brain-spinal cord samples. The system comprises a brain-spinal cord sample fixing device, an internal processing box and an external processing box, the fixing device comprises a base, a brain fixing groove and a spinal cord fixing groove, wherein the brain fixing groove and the spinal cord fixing groove are formed in the base and communicate with each other. A frame is arranged in the internal processing box and comprises a plurality of guide rails for embedding the fixing device; and the external processing box is used for accommodating the internal processing box so as to perform unified reagent processing on the whole sample group. The invention also discloses a method for batch processing of brain-spinal cord samples by using the system. According to the invention, by designing the modularized sample bearing unit and the reagent treatment outer box, synchronous and standardized treatment of a plurality of samples is realized. A plurality of samples can be processed at the same time, and the processing efficiency is greatly improved; the height consistency between samples is ensured, batch errors are eliminated to the maximum extent, and the data comparability is ensured; and human intervention and injury are reduced to the greatest extent.

The application relates to the technical field of a brain-computer interface driven wearable adaptive brain-spinal cord synergistic neural regulation system, and particularly discloses a brain-computer interface driven wearable adaptive brain-spinal cord synergistic neural regulation system, which aims to solve the problems of brain and spinal cord regulation device synergistic stimulation, brain signal decoding based on a brain-computer interface, and a closed-loop adaptive neural regulation mechanism. The system comprises a brain-computer interface signal acquisition and decoding module, a multi-modal physiological state sensing module, and an adaptive brain-spinal cord synergistic neural regulation decision and execution module. The system realizes closed-loop adaptive neural intervention by collecting electroencephalogram and electromyogram signals in real time and dynamically generating brain and spinal cord synergistic regulation parameters. The application improves the individualization, precision and continuity of neural function repair, and has wearable integration and safety monitoring capabilities.

Systems and methods for treating neurodegenerative disorders with high frequency stimulation are disclosed. A representative method for treating a patient includes applying an electrical signal to the patient via a treatment system that includes a signal delivery element positioned at or within a white matter of the patient's brain, spinal cord, or both, the electrical signal having a frequency of from about 1.5 kHz to about 100 kHz.

The utility model relates to the field of medical instruments, and discloses a craniocerebral spinal cord surgery suction tube capable of assisting manual control, which comprises a suction tube, one end of the suction tube is fixedly connected with a control sleeve, the inside of the control sleeve is rotatably connected with a sealing ball, and the outer wall of the sealing ball is fixedly connected with an adjusting valve. The adjusting valve is rotatably connected to the interior of the control sleeve, the outer wall of the sealing ball is fixedly connected with a limiting column, the limiting column is rotatably connected to the interior of the control sleeve, positioning grooves arranged in an annular array are formed in the limiting column, a limiting assembly is arranged in the control sleeve, and the limiting assembly is used for preventing the sealing ball from rotating at will. According to the suction tube for the craniocerebral spinal cord surgery, the sealing ball is limited in the control sleeve through the limiting column, and the control sleeve is embedded into the positioning groove through the clamping column at one end of the N-shaped supporting rod, so that the effect of limiting the valve is achieved, the problem that the position of the valve is easy to change during suction and the suction force is changed is solved, and the stability of the suction tube for the craniocerebral spinal cord surgery is improved.

Based on combination therapy, we propose a cell therapy that can significantly enhance the therapeutic effect of treatment for cerebrovascular disease, ischemic heart disease, or traumatic cerebrospinal nerve injury in subjects compared to conventional methods. [Solution] A cell preparation containing microglia and / or monocytes, which have the ability to promote angiogenesis and axon extension, is administered to the subject. By repeatedly implementing a bidirectional biofeedback loop between the nervous system and the musculoskeletal system, the effect of improving the motor function of the subject's brain, nervous system, and muscular system is enhanced.

This invention discloses an AI-powered intelligent embolization assistance system for arteriovenous malformations of the brain and spinal cord. By integrating an AI-powered intelligent embolization assistance subsystem and an image-guided platform, it matches 3D-DSA angiography images with internally stored hydrodynamic models of different embolization materials to obtain a three-dimensional vascular architecture map of the lesion and surrounding vessels. Through AI calculation, it completes virtual path planning, simulating the embolization path, three-dimensional course, and embolization range. Based on this, it provides real-time navigation of the microcatheter during EVT, intelligently following its path. After the procedure, it re-acquires 3D-DSA angiography images, performs multimodal image fusion, and assesses the embolization status, the three-dimensional relationship with surrounding structures, and potential related complications. This system enables preoperative planning and simulation of the interventional embolization path and range, and real-time navigation, tracking, and assessment of the lesion during the procedure, effectively improving the efficacy of EVT.

Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with increased viral transduction enrichment in the brain, spinal cord, and / or heart. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Gene therapy using the rAAVs is described. Also described are methods of treating diseases of the brain, spinal cord, and / or heart-related diseases and conditions.

Methods for the use of glutathione trisulfide (GSSSG) in neuroprotection, e.g., in neurodegenerative diseases and to reduce the risk of ischemic injury. The methods can be used, e.g., to reduce risk of injury to brain, spinal cord, and peripheral nerves from ischemia or low blood flow states possibly caused by surgery, trauma, and other conditions that decrease / impair blood flow and or oxygen delivery to the nervous system.

The application relates to the field of closed-loop neuromodulation and functional reconstruction, and discloses a closed-loop brain-spinal cord interface upper limb grasping function reconstruction method and system based on multi-modal biological feedback. The method synchronously collects at least three kinds of feedback information such as joint angle, grasping force and electromyographic signal, generates a comprehensive actual motion state through weighted fusion, creatively adopts a hierarchical adjustment strategy according to an error vector between a desired state and an actual state, and differentiates and adaptively adjusts parameters such as stimulation current intensity, frequency and pulse width, calculates a fatigue index based on electromyographic frequency domain characteristics (such as a median frequency and an average power frequency), and superimposes a fatigue compensation strategy to perform prospective intervention. The method effectively solves the problems of low control precision, insufficient single feedback dimension information and insufficient continuous motion capacity of existing systems, and significantly improves the precision, adaptability and long-term stability of motion control.

The invention relates to a method and a device using said method that determine the time constant and thus the cerebrospinal fluid pressure in order to calculate, at high speed and with high accuracy, intracranial pressure (ICP) measurements performed with a spinal manometer of the cerebrospinal fluid (CSF) pressure value, without requiring the characteristics of the spinal needle used for lumbar puncture.

Among the various aspects of the present disclosure is the provision for systems and methods that employ a multielectrode transdermal spinal stimulation (tSCS) device configured to provide spatiotemporal transcutaneous spinal cord stimulation. In some aspects, the predetermined pattern is configured to sequentially activate and recruit individual muscle groups in a sequence configured to assist in the subject's movements such as walking. Among various other aspects a non-invasive brain-spine interface (BSI) system is disclosed that facilitate movements such as leg movements in a subject with a spinal cord injury (SCI). The BSI system includes a wearable EEG array to monitor brain activity, and a computer to identify intended movement by the subject based on the monitored brain activity. In response to the detection of an intended movement by the BSI system, the tSCS device activates the multielectrode transdermal spinal stimulation device to facilitate the intended movement of the subject.