34 results about "Brain spinal cord" patented technology

The invention relates to the field of closed-loop nerve regulation and function reconstruction, and discloses a closed-loop brain-spinal cord interface upper limb grasping function reconstruction method and system based on multi-modal biofeedback. According to the method, at least three kinds of feedback information such as joint angles, grabbing force and electromyographic signals are synchronously collected, and a comprehensive actual motion state is generated through weighted fusion; according to an error vector between an expected state and an actual state, a hierarchical adjustment strategy is creatively adopted to carry out differentiation and adaptive adjustment on parameters such as stimulation current intensity, frequency and pulse width; and fatigue indexes are calculated based on myoelectricity frequency domain characteristics (such as median frequency and average power frequency), and prospective intervention is carried out by superimposing a fatigue compensation strategy. The method effectively solves the problems that an existing system is low in control precision, insufficient in single feedback dimension information and insufficient in continuous motion ability, and the precision, adaptability and long-term stability of motion control are remarkably improved.

This invention involves, among other things, elements that stimulate an immune response. Which includes: a) one or more antigens of Avibacterium paragallinarum and One or more antigens of avian brain and spinal cord rhizomatous virus and one antigen. or more of avian porcine ... Furthermore, this invention relates to a method for immunizing animals which includes administration. The animal drug contains components that stimulate the immune response of this invention; moreover, This invention relates to a method of treating or preventing clinical signs caused by Avibactericum. Paragallinarum, a viral infection that causes encephalitis and spinal cord inflammation in birds and avian pox virus in animals. Essential, a method that involves administering medication to animals in effective dosages as a form of treatment. The components that stimulate an immune response are consistent with this invention;

Embodiments of the present application disclose a brain-spinal cord interface system. The system can include a first acquisition module, a decoding module, a conversion module, and a stimulation module. The first acquisition module is configured to acquire neural signals of a brain of a target subject to obtain target neural signals representing a movement intention of the target subject. The decoding module is configured to decode the target neural signals to obtain the movement intention. The conversion module is configured to convert the movement intention into target ultrasound stimulation parameters. The stimulation module is configured to stimulate a spinal cord of the target subject based on the target ultrasound stimulation parameters. The technical solution of the embodiments of the present application can better reconstruct the functional connection between the brain and the spinal cord.

Implantable devices and / or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices / sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and / or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

The invention provides an infrared light release hydrogen sulfide nanoreactor. The infrared light release hydrogen sulfide nanoreactor comprises an injectable PVA / PVP transparent conductive hydrogel and an SNSs / PEI-DTC compound, wherein the interior of the injectable PVA / PVP transparent conductive hydrogel is filled with the SNSs / PEI-DTC compound; the SNSs / PEI-DTC compound is prepared from a donor PEI-DTC and a two-dimensional silylene nanosheet loaded on the surface of the donor PEI-DTC. The invention innovatively provides a light field in-situ controlled release hydrogen sulfide treatment gas for protecting spinal cord neurons from secondary injury, and due to the advantage of good lipid solubility of hydrogen sulfide, the hydrogen sulfide is extremely easy to pass through a blood brain spinal cord barrier and a cell membrane barrier to enter an intracellular structure for treatment of spinal cord injury.

The present invention relates to a neuromodulation / neurostimulation system (100) for restoring motor function of an upper limb and / or a lower limb of a patient (P) suffering from spinal cord injury (SCI) and / or other neurological conditions and promoting neurological restoration, the system (100) comprising: a processing unit (10) configured and adapted to provide stimulation commands; an implantable or external stimulation unit (12) configured and adapted to deliver neuromodulation therapy, in particular electrical epidural stimulation (EES), to the dorsal root of the spinal cord (SC) of the patient (P); at least one implantable or external pulse generator (14), the at least one implantable or external pulse generator being operatively connected to the stimulation unit (12); an implantable neural sensor (16), the implantable neural sensor comprising an electronic component configured and adapted to detect a cerebral electrocorticogram (ECoG) signal representing a motor intent of the patient (P) from a sensory motor cortex (C) of the patient (P), wherein the processing unit (10), the stimulation unit (12) and the implantable neural sensor (16) are operatively connected to define a cerebrospinal cord interface (BSI), and wherein the processing unit (10) is configured and adapted to: preferably collect the ECoG signals from the sensory motor cortex (C) in real time and decode the ECoG signals into corresponding motor intent of the patient (P); the decoded motion intent is converted, preferably in real time, into a corresponding stimulation command, and the stimulation command is forwarded, preferably in real time, to the at least one pulse generator (14).

The invention discloses an efficient blood brain barrier crossing adeno-associated virus mutant and application, and relates to the technical field of biological medicine. A587Q588 in the amino acid of the AAV9 serotype capsid protein is replaced by a heterologous peptide; the heterologous peptide is a polypeptide consisting of any one of amino acid sequences in DGTIQAPFR (Databine Glycine Triphosphate Quantitative Amplified Polypeptide Receptor) or DGTTFTPPR ( The infection efficiency, mRNA (messenger ribonucleic acid) and protein expression of the SG302 and the SG303 on brain, spinal cord and thalamic neurons of a mouse are obviously higher than those of AAV9, and the infection capacity on the liver is obviously lower than that of the AAV9. The SG302 and the SG303 are serotype mutants with good specificity for a nervous system, the high infection efficiency can reduce the administration dosage, and the low hepatotrophy characteristic can improve the safety performance.

Ventricular catheters and their methods of use are disclosed. In some embodiments, the disclosed ventricular catheters may reduce, or substantially prevent, obstruction of the catheter by astrocytes or other brain tissue due to adhesion and / or growth within the catheter. For example, in some embodiments, the holes and internal lumen of a ventricular catheter may be constructed such that the wall shear stresses applied within the holes and internal lumen of the catheter are greater than a threshold shear stress to prevent cell adhesion and growth within the catheter.

The application discloses a waterproof and breathable type brain and spinal cord nerve injury wound protection dressing, which is sequentially stacked and arranged from inside to outside as a wound adhesion inner layer, a functional sustained-release middle layer and a waterproof and breathable outer layer; the three-layer synergistic dressing structure of the wound adhesion inner layer, the functional sustained-release middle layer and the waterproof and breathable outer layer is constructed, waterproof sealing and the dynamic adaptation of the air permeability performance of the brain and spinal cord nerve injury wound are realized, the target anti-scar polypeptide is covalently bonded on the inner layer, the effective inhibition of excessive scar hyperplasia and neuroma formation is realized, the matching regulation of the gradient degradation drug-loaded microsphere system and the air permeation pore size of the middle layer is realized, the accurate release of active factors in the whole cycle of nerve repair is realized, the long-acting waterproof and breathable protection in a dynamic scene is realized through the design of the outer layer of super-hydrophobic nanofiber membrane, the risk of postoperative complications is reduced, and the integration and synergy of the physical protection of the wound and the nerve function repair are realized.

Methods and devices for the nasal administration of compositions comprising glutathione trisulfide (GSSSG), pantethine trisulfide (PTN-SSS), or lipoic acid trisulfide (LA-SSS) in neuroprotection, e.g., in neurodegenerative diseases and to reduce the risk of ischemic injury. The methods can be used, e.g., to reduce risk of injury to brain, spinal cord, and peripheral nerves from ischemia or low blood flow states possibly caused by surgery, trauma, and other conditions that decrease / impair blood flow and or oxygen delivery to the nervous system.

The invention belongs to the technical field of experimental devices, and provides a fixing device for a brain-spinal cord sample of a mouse. The device comprises a base, a brain fixing groove and a spinal cord fixing groove, wherein the brain fixing groove and the spinal cord fixing groove are formed in the base and are communicated; the brain fixing groove is a bionic groove matched with the anatomical contour of the lateral hemisphere of the mouse brain and used for containing the lateral hemisphere of the mouse brain and exposing the tail end of the brainstem. The spinal cord fixing groove is a spiral bionic groove matched with the side dissection outline of the mouse spinal cord and used for containing the side face of the mouse spinal cord and enabling the spinal cord and the tail end of the brainstem to keep a natural connection angle. According to the invention, through the design of the bionic grooves and the buckles, each sample is ensured to be fixed in the same form; the structure of the mold limits the coiling path of the spinal cord, so that the embedding length becomes controllable and repeatable; through the preset coiling path and the buckle, the spinal cord is stabilized in the preset direction and prevented from being twisted, and the axon tracking accuracy is guaranteed.

Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) that have increased viral transduction enrichment in the brain, spinal cord, and / or heart. The rAAV compositions described herein encoat transgenes, such as therapeutic nucleic acids. Gene therapies using these rAAVs are described. Methods of treating brain, spinal cord and / or heart related diseases and conditions are also described.

The invention belongs to the technical field of experimental devices, and provides a batch processing system and method for brain-spinal cord samples. The system comprises a brain-spinal cord sample fixing device, an internal processing box and an external processing box, the fixing device comprises a base, a brain fixing groove and a spinal cord fixing groove, wherein the brain fixing groove and the spinal cord fixing groove are formed in the base and communicate with each other. A frame is arranged in the internal processing box and comprises a plurality of guide rails for embedding the fixing device; and the external processing box is used for accommodating the internal processing box so as to perform unified reagent processing on the whole sample group. The invention also discloses a method for batch processing of brain-spinal cord samples by using the system. According to the invention, by designing the modularized sample bearing unit and the reagent treatment outer box, synchronous and standardized treatment of a plurality of samples is realized. A plurality of samples can be processed at the same time, and the processing efficiency is greatly improved; the height consistency between samples is ensured, batch errors are eliminated to the maximum extent, and the data comparability is ensured; and human intervention and injury are reduced to the greatest extent.

The application relates to the technical field of a brain-computer interface driven wearable adaptive brain-spinal cord synergistic neural regulation system, and particularly discloses a brain-computer interface driven wearable adaptive brain-spinal cord synergistic neural regulation system, which aims to solve the problems of brain and spinal cord regulation device synergistic stimulation, brain signal decoding based on a brain-computer interface, and a closed-loop adaptive neural regulation mechanism. The system comprises a brain-computer interface signal acquisition and decoding module, a multi-modal physiological state sensing module, and an adaptive brain-spinal cord synergistic neural regulation decision and execution module. The system realizes closed-loop adaptive neural intervention by collecting electroencephalogram and electromyogram signals in real time and dynamically generating brain and spinal cord synergistic regulation parameters. The application improves the individualization, precision and continuity of neural function repair, and has wearable integration and safety monitoring capabilities.

The present invention provides methods for the treatment of a central nervous system (CNS) tumor in a subject comprising administering and IL-4 targeted cargo protein formulated in an artificial cerebral spinal fluid formulation. The present invention also provides formulations and methods for administration along with a surrogate tracer for monitoring.

Systems and methods for treating neurodegenerative disorders with high frequency stimulation are disclosed. A representative method for treating a patient includes applying an electrical signal to the patient via a treatment system that includes a signal delivery element positioned at or within a white matter of the patient's brain, spinal cord, or both, the electrical signal having a frequency of from about 1.5 kHz to about 100 kHz.

The utility model relates to the field of medical instruments, and discloses a craniocerebral spinal cord surgery suction tube capable of assisting manual control, which comprises a suction tube, one end of the suction tube is fixedly connected with a control sleeve, the inside of the control sleeve is rotatably connected with a sealing ball, and the outer wall of the sealing ball is fixedly connected with an adjusting valve. The adjusting valve is rotatably connected to the interior of the control sleeve, the outer wall of the sealing ball is fixedly connected with a limiting column, the limiting column is rotatably connected to the interior of the control sleeve, positioning grooves arranged in an annular array are formed in the limiting column, a limiting assembly is arranged in the control sleeve, and the limiting assembly is used for preventing the sealing ball from rotating at will. According to the suction tube for the craniocerebral spinal cord surgery, the sealing ball is limited in the control sleeve through the limiting column, and the control sleeve is embedded into the positioning groove through the clamping column at one end of the N-shaped supporting rod, so that the effect of limiting the valve is achieved, the problem that the position of the valve is easy to change during suction and the suction force is changed is solved, and the stability of the suction tube for the craniocerebral spinal cord surgery is improved.

The invention relates to methods for monitoring the implementation of physical rehabilitation therapy in the case of diseases related to impaired blood circulation and cerebrospinal fluid circulation in the brain, as well as in the case of myotonic syndrome. Prior to commencement of physical rehabilitation therapy, data about the patient's continuous electrical potentials in five zones, frontal (Fz), central / parietal (Cz), occipital (Oz), right (Td) and left (Ts), are obtained by neural energy mapping. The obtained readings are compared with a norm, determining any deviation from the norm (mV). Physical rehabilitation therapy is implemented with neural energy mapping being carried out in real time. The therapy implemented is adjusted if the readings obtained deviate from the norm. The method makes it possible to monitor the implementation of physical rehabilitation therapy in the case of diseases related to impaired blood circulation and cerebrospinal fluid circulation in the brain, as well as in the case of myotonic syndrome.

The invention discloses a multifunctional active nerve scaffold and a preparation method thereof, and belongs to the technical field of tissue engineering nerve scaffolds. The nerve scaffold is composed of a gel layer, a response layer and a cell layer. Wherein the gel layer has conductivity similar to that of nervous tissue and program-controlled deformation and tissue wet adhesion capability under the triggering of water or physiological liquid; the response layer has specific surface topological morphology and power generation capacity under the remote control of external fields such as light, ultrasound and magnetism, and can regulate and control migration and proliferation of cells in the cell layer and release of bioactive substances such as growth factors and exosomes based on topological morphology mediated biomechanical signals and bioelectrical signals generated under the remote control of the external fields. Based on the functions, the multifunctional active nerve scaffold can be used for tissue regeneration and functional reconstruction of nerve injury (such as brain, spinal cord, optic nerve and peripheral nerve). The invention also provides a preparation method of the multifunctional active nerve scaffold.

Poly(ADP-ribose) (PAR) is a protein implicated in numerous neurodegenerative disease states including Parkinson's disease (PD). To date, no routine laboratory test has been developed to diagnosis, assess or monitor patients suffering from PD. Disclosed herein a novel method to assess the PAR concentration in the cerebral spinal fluid (CSF) of a patient and correlate that concentration to the medical condition of a patient with PD. Also disclosed is the use of PAR as a biomarker for PD.

Based on combination therapy, we propose a cell therapy that can significantly enhance the therapeutic effect of treatment for cerebrovascular disease, ischemic heart disease, or traumatic cerebrospinal nerve injury in subjects compared to conventional methods. [Solution] A cell preparation containing microglia and / or monocytes, which have the ability to promote angiogenesis and axon extension, is administered to the subject. By repeatedly implementing a bidirectional biofeedback loop between the nervous system and the musculoskeletal system, the effect of improving the motor function of the subject's brain, nervous system, and muscular system is enhanced.

A shunt for treating hydrocephalus and a system thereof. The shunt (1) comprises a distal portion (13) provided with a cerebrospinal fluid inlet, a proximal portion (12) provided with a cerebrospinal fluid outlet, and a tube body (11) provided with a flow lumen (15). The distal portion (13) is provided with a limiting part (14) for contacting a dura mater. The maximum radial dimension of the limiting part (14) in a delivery state is greater than the minimum radial dimension of a puncture orifice and the tube body. The shunt system comprises the shunt (1) and a delivery system. The delivery system is used for delivering the shunt (1) to a designated position in a venous system and a ventricular system. In the delivery process, the shunt (1) is placed within the delivery system. By means of the distal portion (13) of the shunt (1), the dural puncture orifice is dilated, and the limiting part (14), whose dimension is larger than that of the puncture orifice, is pressed into a cistern. By utilizing the elastic recovery capability of the biological membrane itself, the limiting part (14) and the dura mater form a locking anchorage. The limiting part (14) is limited by its own dimensions. The structure and the operation are simple, thereby simplifying the delivery process and the delivery system.

Methods and devices for nasal administration of a composition comprising glutathione trisulfide (GSSSG), pantethine trisulfide (PTN-SSS), or lipoic acid trisulfide (LA-SSS) in neuroprotection (e.g., in neurodegenerative disease) and in order to reduce the risk of ischemic injury. The methods may be used, for example, to reduce the risk of ischemia or low blood flow conditions causing injury to the brain, spinal cord, and peripheral nerves that may result from surgery, trauma, and other conditions that reduce / damage blood flow and / or oxygen delivery to the nervous system.

The present disclosure relates generally to controlling a volume of fluid within a portion of a patient's body. For example, the present disclosure can relate to the addition or removal of cerebral spinal fluid (CSF) from a portion of the patient's brain. The amount of fluid can be controlled by a system that includes a dual chamber probe and a volume control. One channel can include a drain element to drain the fluid from the portion of a patient's body. The other channel can include a volume changing element to facilitate the drainage of the fluid by changing a volume of the portion of the patient's body. The volume changing element can be coupled to a volume control, which can control the change of the volume of the portion of the patient's body (e.g., based on passive oscillation or active oscillation).

The present invention provides a system for treating a patient having a spinal cord injury, the system comprising: a first flexible implantable device having a first plurality of electrodes; a second flexible implantable device having a second plurality of electrodes; and a controller communicatively coupled to the electrodes of the first and second implantable devices, and configured to receive an input signal from the electrode of the first implantable device, process the input signal to generate a stimulation signal, and transmit the stimulation signal to the electrode of the second implantable device. The device may be configured for implantation at a plurality of sites in a patient, including the brain, spinal cord, nerve, or limb. The controller may be configured to: process the input signal by decoding the input signal to determine an expected stimulation of a patient's nerve at the head end of the location of the first device on the spinal cord; and generating a stimulation signal that produces the intended stimulation of the nerve of the patient when the stimulation signal is applied to the spinal cord of the patient by the second device. Methods of treating spinal cord injury are also provided.

The present invention relates to an agent for protection of vascular endothelial cells, an agent for protection of blood brain spinal cord barrier, and an agent for protection of central nervous system, containing at least one compound selected from the group consisting of muvritinib, brexpiprazole, papaverine, bismuth-containing compounds, and pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical composition for the treatment of diseases associated with blood brain spinal cord barrier disruption, containing at least one compound selected from the group consisting of muvritinib, brexpiprazole, papaverine, bismuth-containing compounds, and pharmaceutically acceptable salts thereof.

This invention discloses an AI-powered intelligent embolization assistance system for arteriovenous malformations of the brain and spinal cord. By integrating an AI-powered intelligent embolization assistance subsystem and an image-guided platform, it matches 3D-DSA angiography images with internally stored hydrodynamic models of different embolization materials to obtain a three-dimensional vascular architecture map of the lesion and surrounding vessels. Through AI calculation, it completes virtual path planning, simulating the embolization path, three-dimensional course, and embolization range. Based on this, it provides real-time navigation of the microcatheter during EVT, intelligently following its path. After the procedure, it re-acquires 3D-DSA angiography images, performs multimodal image fusion, and assesses the embolization status, the three-dimensional relationship with surrounding structures, and potential related complications. This system enables preoperative planning and simulation of the interventional embolization path and range, and real-time navigation, tracking, and assessment of the lesion during the procedure, effectively improving the efficacy of EVT.

The present invention discloses a real-time evaluation method for the effect of transcranial direct current intervention stimulation, which specifically relates to the field of transcranial direct current effect evaluation, including: collecting multi-channel brain nerve electrical signals from a set cerebral cortex area, calculating its complexity change using multi-scale entropy, and establishing a complexity change time series before and after transcranial direct current intervention stimulation. Synchronously collecting nerve reflex signals from a set spinal cord segment, extracting high-frequency energy density time series using fast Fourier transform, establishing brain-spinal cord cross-regional neural signal association, and calculating the trend correlation of feature changes. Extracting brain nerve electrical signals and spinal cord reflex signals within a set frequency domain range, converting them into instantaneous phase expressions, calculating the frequency locking ratio through phase difference, and forming a phase synchronization time series. Mapping the phase synchronization time series to a high-dimensional space, combining the geometric characteristics of phase synchronization and trend correlation, and comprehensively calculating the evaluation value of the transcranial direct current intervention stimulation effect.

Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with increased viral transduction enrichment in the brain, spinal cord, and / or heart. The rAAV compositions described herein encapsidate a transgene, such as a therapeutic nucleic acid. Gene therapy using the rAAVs is described. Also described are methods of treating diseases of the brain, spinal cord, and / or heart-related diseases and conditions.

Methods for the use of glutathione trisulfide (GSSSG) in neuroprotection, e.g., in neurodegenerative diseases and to reduce the risk of ischemic injury. The methods can be used, e.g., to reduce risk of injury to brain, spinal cord, and peripheral nerves from ischemia or low blood flow states possibly caused by surgery, trauma, and other conditions that decrease / impair blood flow and or oxygen delivery to the nervous system.