The invention discloses a
silicified microcrystalline cellulose composite auxiliary material and a preparation method thereof, belonging to the field of medical premixed composite auxiliary materials. The
silicified microcrystalline cellulose composite auxiliary material disclosed by the invention consists of the following components in parts by
mass: 25.2-25.5 parts of
microcrystalline cellulose, 0.5-0.8 part of
silicon dioxide, 0.08 part of hydroxypropyl methylcellulose K4M and 74 parts of water. The preparation method comprises the following steps: (1) dissolving the hydroxypropyl methylcellulose K4M and water, adding the dissolved substances into a stirrer, adding the
silicon dioxide, stirring, adding the
microcrystalline cellulose, and stirring, thereby obtaining uniform suspension A; (2) setting the air
inlet temperature at 160 DEG C by using a centrifugal
spray dryer, setting the outlet temperature at 95 DEG C, setting the rotating speed of an atomizer at 8000
revolutions per minute, setting the rotating speed of a
peristaltic pump at 20
revolutions per minute, and
drying, thereby obtaining a material B; (3) adding the material B into a screening
machine, vibrating and screening to the
granularity of 80 meshes, thereby obtaining
sieve residues C; and (4) testing the samples of
sieve residues C, thereby obtaining the product of which the quality accords with the regulation, namely the composite auxiliary material. According to the composite auxiliary material and the preparation method thereof provided by the invention, the requirement of directly pressing the
powder is met, so that the product is uniform in tablet weight, large in tablet
hardness, smooth in tablet and qualified in
dissolution rate.