The invention discloses a silicified microcrystalline cellulose composite auxiliary material and a preparation method thereof, belonging to the field of medical premixed composite auxiliary materials. The silicified microcrystalline cellulose composite auxiliary material disclosed by the invention consists of the following components in parts by mass: 25.2-25.5 parts of microcrystalline cellulose, 0.5-0.8 part of silicon dioxide, 0.08 part of hydroxypropyl methylcellulose K4M and 74 parts of water. The preparation method comprises the following steps: (1) dissolving the hydroxypropyl methylcellulose K4M and water, adding the dissolved substances into a stirrer, adding the silicon dioxide, stirring, adding the microcrystalline cellulose, and stirring, thereby obtaining uniform suspension A; (2) setting the air inlet temperature at 160 DEG C by using a centrifugal spray dryer, setting the outlet temperature at 95 DEG C, setting the rotating speed of an atomizer at 8000 revolutions per minute, setting the rotating speed of a peristaltic pump at 20 revolutions per minute, and drying, thereby obtaining a material B; (3) adding the material B into a screening machine, vibrating and screening to the granularity of 80 meshes, thereby obtaining sieve residues C; and (4) testing the samples of sieve residues C, thereby obtaining the product of which the quality accords with the regulation, namely the composite auxiliary material. According to the composite auxiliary material and the preparation method thereof provided by the invention, the requirement of directly pressing the powder is met, so that the product is uniform in tablet weight, large in tablet hardness, smooth in tablet and qualified in dissolution rate.