The invention discloses a direct pasting uterus warming paste capable of soothing nerves and relieving pain and a preparation method and an application of the direct pasting uterus warming paste. Theuterus warming paste sequentially comprises an adhesion layer, a graphene layer, a spice layer and a heating layer, the spice layer comprises the following fillers: radix angelicae, cinnamon, folium artemisiae argyi, rhizoma zingiberis, fennel, clove, fructus amomi, and agilawood; the heating layer comprises the following fillers: an iron powder, water, activated carbon, vermiculite, a water-absorbent resin, sodium chloride and ultra-low sulfur expandable graphite. The direct pasting uterus warming paste is a type of drug for external use for the healthcare of women, can be directly pasted onthe skin of the woman, is used directly, has obvious effects, and therefore has the effects of relieving exterior syndrome and dispelling cold, soothing nerves, tranquilizing, promoting qi circulationand relieving pain, and is more favorable for alleviating the dysmenorrhea symptoms of women.