The invention discloses a negative pressure waste gas discharge disinfection and sterilizer and a manufacturing method thereof, which comprises a housing, a gas pipeline, a junction box and a heating element. Both ends of the housing are provided with protective covers, and the size of the opening of the protective cover is along the The center of the shell gradually decreases toward the end, and the inner cavity of the protective cover communicates with the gas pipeline. The method includes: a, installing a protective cover welding device; b, welding to obtain a protective cover with an initial shape; c, welding an inner cavity in the protective cover with an initial shape; d, cutting to obtain a formed protective cover; The sealing plate is welded and fixed; f, the protective cover is painted; g, the protective cover is respectively welded on both ends of the shell; h, the bottom of the junction box is sealed on the shell. The invention can avoid the phenomenon of gas leakage, reduce the temperature of the exhaust at the same time, improve the safety, and increase the processing air volume; and solve the technical problem that the inside of the truss-shaped protective cover is not easy to weld, and increase the vertical pressure bearing of the protective cover Capability, can be welded in batches to get the protective cover.