The invention relates to a variable gain correlated double sampling circuit and a control method. The variable gain correlated double sampling circuit is provided with a switch K1, a switch K2, a switch K3, a switch K4, a switch K5, a switch K2_b, a switch K3_b, a switch K4_b, a switch K5_b, a capacitor C1, a capacitor C2, an operational amplifier OPA and a variable gain control module G, and is also provided with a circuit with a symmetrical structure: a node A' is symmetrical with the node A, a node B' is symmetrical with the node B, a node C' is symmetrical with the node C, a node D' is symmetrical with the node D, and a node E' and a node E are symmetrical; the circuit structure located at the in-phase input end of the operational amplifier is the same as the circuit structure located at the anti-phase input end of the operational amplifier, the in-phase output end of the operational amplifier outputs a signal VOUTP, and the anti-phase output end of the operational amplifier outputs a signal VOUTN. Parallel work of the sampling circuit and the holding and amplifying circuit is realized, pixel correction is not needed, and subsequent image processing work is simplified. And after the differential signal is amplified, the post-stage numerical quantization ADC index requirement is reduced.