The invention relates to low-GI total-nutrient meal replacement powder for intervening polycystic ovarian syndrome based on a ketogenesis principle and application of the low-GI total-nutrient meal replacement powder. The meal replacement powder is prepared from the following raw materials: freshly squeezed coconut oil, conjugated linoleic acid glyceride, linseed oil, olive oil, fish oil, high oleic acid sunflower seed oil, soybean oil, whey protein concentrate, soy isolate protein, hydrolyzed fish collagen, casein, rice protein, quinoa flour, chia seeds, konjac powder, inulin, fructo-oligosaccharide, L-carnitine, glutamine, enzymes, vitamin complex and mineral complex. The formula has the advantages that the energy supply ratio of the three nutrients is as follows: 70%-75% of fat, 3%-5% of carbohydrate and 20%-27% of protein. By utilizing the characteristics that MCT (medium-chain fatty acid) does not store fat and can quickly supply energy to a human body, insulin resistance is reduced, glycolipid metabolism disorder is improved, and the purpose of reducing weight is achieved. A scientific and convenient ketogenic diet replacement scheme is provided, and the ketogenic diet replacement scheme is convenient to implement and popularize in crowds.