The invention discloses a fire extinguishing agent containing modified medical stone powder, which is prepared from the following raw materials in parts by weight: 50-80 parts of modified medical stone powder, 5-10 parts of talcum powder, 10-15 parts of zinc sulfide hydrate, 3-5 parts of calcium carbonate, 5-8 parts of magnesium stearate, 3-5 parts of methyl silicone oil, 2-3 parts of hydrophobic silica white, 3-5 parts of atlapulgite, 2-3 parts of perlite, 2-3 parts of ethylene glycol, 5-8 parts of calcium lignosulphonate, 3-5 parts of bamboo charcoal fiber, 2-3 parts of industrial essence, 2-4 parts of zinc borate, 1-3 parts of chlorinated paraffin, 5-10 parts of glass bead and 8-10 parts of kieselguhr. The fire extinguishing agent has the advantages of high fire extinguishing efficiency, high moisture resistance, favorable after-combustion resistance, environment friendliness and simple production technique, and is suitable for various fire hazards.