The invention relates to a prehardening plastic die steel plate and a manufacture method thereof. The steel plate comprises, by weight, C 0.28 to 0.40, Si 0.20 to 0.80, Mn 0.60 to 1.0, Cr 1.40 to 2.2, Mo 0.30 to 0.50, P no more than 0.030, S no more than 0.030, Al 0.01 to 0.08, Ti 0.01 to 0.05 and B 0.0010 to 0.0050, with the balance being Fe and unavoidable impurities. The manufacture method comprises a first step of smelting, that is, carrying out tapping and casting when components in liquid steel meet requirements so as to obtain steel ingots, a second step of hot rolling, that is, rolling the steel ingots into steel plates with a thickness of 60 to 200 mm, a width of 300 to 1500 and a length of 2000 to 8000 mm, a third step of cooling, that is, cooling the steel plates to a temperature below 550 DEG C, wherein, slow cooling time is no less than 24 hours, and a fourth step of tempering, that is, arranging the steel plates in a tempering furnace for tempering at a temperature of 400 to 600 DEG C, carrying out insulation for 4 to 12 hours, taking the steel plates out of the tempering furnace and cooling the steel plates to room temperature in the air. The difference of surface hardness of prehardening plastic die steel plates manufactured in the invention is within 20 HB.