The invention discloses a
quadrupole rod power source calibration method and device and a storage medium, and the method comprises the steps: obtaining an initial correction coefficient of a
quadrupole rod power source, and building an initial
voltage correction equation based on a
quadrupole rod
ion motion equation; setting a characteristic
mass number, a target resolution and a pre-scanning range, and collecting
spectrogram data in the pre-scanning range according to the initial
voltage correction equation; presetting a
mass number deviation initial value, dynamically adjusting the
mass number deviation according to a comparison result of the resolution in the
spectrogram data and the target resolution, and positioning a preliminary spectrum peak corresponding to the characteristic
mass number; performing iterative adjustment on the resolution error and the peak error, optimizing the correction coefficient and the initial correction coefficient until the error between the peak center and the characteristic
mass number is smaller than a preset threshold value, and determining a final correction coefficient; and calibrating the spectrum peak of the whole mass axis based on the final correction coefficient to complete quadrupole rod power supply calibration. According to the invention, rapid and accurate quadrupole rod power supply initial parameter calibration can be realized without manual intervention.