A ultra-miniature, electro-mechanical, MEMS type safe and arming (S&A) device for medium- or large-artillery rounds, including, three sequenced S&A interlocks: a setback slider, which is positioned partially within and partially extending from an arming slider, such that, upon firing acceleration, the setback slider will compress into a channel within the arming slider (unlocking the 1st interlock); freeing the arming slider to move toward its arming position under urging of the round's spin; a stop and release mechanism formed by a flexible latch arm which impacts upon a safety catch located within the frame in which the arming slider is mounted, such that the arming slider is stopped until a release command signal is initiated by the fuze circuit, triggering a spot charge which generates an expanding gas wave that flexes the latch arm from contact with the safety catch (unlocking the 2nd interlock), thereby freeing the arming slider to continue its motion into an arming position (unlocking the 3rd interlock) and aligning the parts of the firetrain within the device, such that upon signal from the fuze circuit an output charge from the device will ignite the acceptor charge within the round.