The invention relates to the technical field of aquatic product breeding, in particular to a selenium-enriched fish breeding method. The method comprises the following steps that firstly, a pond is built and treated; secondly, the pond is disinfected before fry are put into the pond; thirdly, selenium-enriched feed and a feed additive are uniformly mixed for feeding, wherein the feed additive is mainly prepared from folium mori, negundo chastetree fruits, pericarpium citri reticulatae viride, pomegranate leaves, pyrrosia lingua, lespedeza cuneata, courled mallow, semen plantaginis, tea residues, herba asafetida, cortex moutan, ligusticum wallichii and the like; fourthly, a water cleaning agent is used for water purification, wherein the water cleaning agent is mainly formed by mixing calcium hypochlorite, sodium dichloro isocyanurate, compound biological enzyme, photosynthetic bacteria, enterococcus faecalis, nitrobacterium and a curing agent; fifthly, timely catching is carried out. According to the breeding method, the feeding amount of fishes can be increased, fishes are made to rapidly and effectively absorb selenium, calcium and the like, and the feed is fully utilized and hasa certain inhibition effect on absorption of fat, so that fish is not greasy, the use rate of chemical medicines is reduced, the morbidity rate of the fishes is reduced, then economic benefits of fish breeding are improved, and the breeding method is environmentally friendly.