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The invention belongs to the technical field of material wear and fatigue life prediction, and discloses a material macro / micro fatigue fracture mechanics-based wear test device, which comprises a bottom plate (1) and a guide rail bracket (2) mounted on the bottom plate (1), a vertical guide rail (3) and a sliding block (4) which slides up and down along the guide rail (3) are arranged on the guide rail frame (2); a sliding block (4) is arranged on the base (1), a cantilever supporting column (6) is fixed on the sliding block (4), a loading device frame (5) is arranged on the cantilever supporting column (6), a loading and mechanical measurement integrated device (7) is assembled on the loading device frame (5), and a loading head (8) is arranged at the front end of the loading and mechanical measurement integrated device (7). The method is based on macroscopic and microscopic fatigue fracture mechanical models of materials, has a deep theoretical basis and wide applicability, and can be suitable for predicting the wear life of different organic materials.