17 results about "Acid–base homeostasis" patented technology

The invention provides a traditional Chinese medicine composition for treating acute altitude sickness. The traditional Chinese medicine composition is prepared from ginseng, astragalus membranaceus, acanthopanax, rhodiola rosea, turnip, salvia miltiorrhiza, dogwood, poria cocos, rhizoma cimicifugae, radix bupleuri, platycodon grandiflorum, aster, elecampane, rhizoma anemarrhenae and liquorice. The traditional Chinese medicine composition disclosed by the invention can be used for treating the acute altitude sickness, remarkably prolonging the load-bearing swimming time of rats, remarkably increasing the arterial oxygen partial pressure and the arterial oxygen saturation of acute altitude sickness model rats and relieving physical fatigue, has obvious effects of resisting anoxia, improving acid-base balance and resisting inflammation, and has obvious curative effects on myocardial injury, liver injury, liver injury and the like. And the kidney injury can be protected.

The invention discloses a novel nanocarbon material with conditioning and treating functions and a preparation method thereof, and belongs to the technical field of health food. According to the novel nano-carbon material, a biological nano-carbon material is organically combined with active magnesium and active silicon, so that a finished product is endowed with unique conditioning and treatment functions. The traditional Chinese medicine composition integrates multiple mechanisms such as sterilization and disinfection, immune enhancement, free radical removal and cell activation, not only has a direct treatment effect on oral inflammation, gastroenteritis, skin inflammation, cyst and the like, but also can fundamentally improve the sub-health state by regulating the acid-base balance of an organism, promoting metabolism and delaying senescence. The whole process is carried out in a 10000-grade clean environment at normal temperature and normal pressure, so that the operation process is simplified, the energy consumption and equipment requirements are reduced, the damage of extreme conditions such as high temperature and high pressure to the activity of the material can be effectively avoided, and the effect of each component is fully exerted.

The invention discloses an application of food-grade sodium carbonate in preparation of a medicine for regulating the acid-base balance of human tissues. The food-grade sodium carbonate conforming to the national food safety standard (GB1886.1) is used as a unique effective component and is dissolved in water to prepare sodium carbonate aqueous solutions with different concentrations, and acid metabolites accumulated in human tissues in local and whole body levels and in human tissues are treated by multiple administration routes such as external use and oral administration. The normal acid-base microenvironment of the tissue is recovered. Wherein the mass concentration of the external preparation is 0.05%-10%, and the mass concentration of the oral preparation is 0.1%-1.5%. The traditional Chinese medicine composition can be used for preventing and / or treating cancers and malignant tumors, stomach diseases related to hyperacidity, femoral head necrosis, muscle strain, frostbite and various diseases taking acid-base imbalance as a common pathological basis. The raw materials are wide in source, low in price and high in safety, the preparation process is simple, the administration scheme is systematic and complete, a single or combined administration route can be flexibly selected according to the specific condition of a patient, and individualized treatment is achieved.

A Smad5 mutant and uses thereof in the prevention and treatment of diabetes. The amino acid sequence of the Smad5 mutant is as shown in SEQ NO ID:1. The invention further relates to a nucleic acid encoding the Smad5 mutant, a recombinant expression vector containing the nucleic acid, and a transformant. The uses also comprise uses of the nucleic acid, the recombinant expression vector containing the nucleic acid, and the transformant in the preparation of a medicament for preventing and / or treating diabetes. The Smad5 mutant can improve symptoms of type 1 and type 2 diabetes in vivo, and, compared with conventional oral hypoglycemic drugs, has no toxic or side effects and does not cause damage to the liver or kidneys of patients. In addition, the invention relates to a reagent for regulating acid-base balance, comprising alkaline drinking water containing baking soda; the reagent can lower blood glucose, alleviate diabetic symptoms, and is more economical and convenient for patients to use.

The invention provides a bacteriostatic soft capsule helpful for improving vaginal relaxation and a preparation method thereof. The soft capsule comprises a soft capsule content and a soft capsule shell, the soft capsule content is prepared from the following raw materials in parts by weight: 3 to 5 parts of fructus corni, 2 to 4 parts of fructus evodiae, 0.8 to 1.2 parts of herba violae, 1 to 3 parts of radix angelicae sinensis, 1 to 2 parts of saffron crocus, 1 to 3 parts of gallnut, 1 to 3 parts of fructus schisandrae chinensis, 0.8 to 1.0 part of sunflower seeds, 0.1 to 0.4 part of geranium, 2 to 4 parts of cortex phellodendri, 1 to 3 parts of folium artemisiae argyi, 0.8 to 1.0 part of pericarpium zanthoxyli and 1 to 3 parts of compound polysaccharide; the soft capsule shell comprises the following raw materials in parts by weight: 1-3 parts of gelatin, 1-3 parts of egg yolk lecithin, 2-4 parts of glycerol and 15-20 parts of deionized water. The soft capsule prepared by the invention integrates the functions of repairing, tightening, nourishing, lubricating, inhibiting bacteria and resisting inflammation, has no irritation to skin and mucous membrane, does not damage the acid-base balance in the body, has no side effect, can obviously improve the vaginal relaxation phenomenon, has strong sterilization and anti-inflammation effects, has a good curative effect on vaginal bacterial infection, eliminates peculiar smell, and has a good application prospect.

FIELD: veterinary science.SUBSTANCE: used to treat dermatitis of parasitic etiology in carnivores. The medications selamectin and fipronil are applied to the skin between the shoulder blades at the base of the animal’s neck. After which they are treated with a solution of ethyl alcohol. Next, using a sprayer, the surface is treated with electrochemically activated water with an acidic fraction with a pH of 2.0 in the amount of 20 ml per 15–20 cm2 for 15–18 s from a distance of 15–18 cm, then held for 40 min, after which the surface is treated with electrochemically activated water with an alkaline fraction with a pH of 9.0 in the amount of 20 ml per 10–12 cm2 for 15–18 s from a distance of 15–18 cm. The treatment is carried out twice a day until the skin heals.EFFECT: method provides for combined highly effective eradication of ectoparasites and suppression of pathogenic microflora with simultaneous acceleration of regeneration of damaged tissues due to the synergistic action of systemic-contact insectoacaricides and sequential local treatment of affected areas of the skin with electrochemically activated solutions with regulated acid-base balance.1 cl, 1 dwg

The invention provides a multifunctional adjusting filter element for escherichia coli culture and a preparation method of the multifunctional adjusting filter element, and relates to the technical field of microorganism culture. The multifunctional adjusting filter element for escherichia coli culture is of a composite sphere structure, the composite sphere structure comprises an inner core and an outer shell, the inner core is of a porous structure, holes are filled with an acid-base buffering agent, and the outer shell sequentially comprises a nutrition supplementing layer and a shell layer from inside to outside. The preparation raw materials of the inner core comprise an inorganic adsorption powder material and ultra-high molecular weight plastic powder, the preparation raw materials of the nutrition supplement layer comprise amino acid, vitamins, glucose, tryptone, a yeast extract and magnesium ions, and the preparation raw material of the shell layer comprises gelatin. The multifunctional adjusting filter element for escherichia coli culture can effectively adjust acid-base balance in the escherichia coli culture process, provide nutrient substances and reduce accumulation of bacteriocin generated in the proliferation and fermentation process, so that the growth speed and density of escherichia coli are increased.

The invention belongs to the technical field of microorganisms, and particularly relates to a novel bacterial culture method. Various nutritional ingredients and growth factors are compounded in the agar culture medium. Due to the addition of glycerol, the property of the culture medium can be stabilized, a certain moisturizing effect is achieved, a certain carbon source can be provided, and growth and metabolism of bacteria are facilitated; the coconut water is rich in various nutrient substances, such as saccharides, amino acids and mineral substances, provides rich natural nutrients for bacteria, and is beneficial to promoting the growth and reproduction of the bacteria; mgSO4, FeCl3 and CaCl2 are added, so that the requirements on trace elements in the growth process of the bacteria can be met, the ion strength and acid-base balance of the culture medium are adjusted, and a good chemical environment is created for the growth of the bacteria; the addition of lecithin may help to simulate the growth environment of bacteria in vivo, promote the growth and metabolism of bacteria, and improve the success rate and positive rate of culture.

The invention discloses an oligochitosan ion slow-release agent and application thereof in animal acid balance regulation, the oligochitosan ion slow-release agent comprises the following active components by weight: 30%-50% of oligochitosan, 25%-40% of oligochitosan sodium and 15%-35% of oligochitosan potassium; the polymerization degree of the chitosan oligosaccharide is 2-20, the number-average molecular weight of the chitosan oligosaccharide is 500-3000Da, and the deacetylation degree of the chitosan oligosaccharide is greater than or equal to 85%; the appearance of the slow-release agent is white to faint yellow crystal powder, the water solubility detected according to the GB / T19466-2004 standard is larger than or equal to 99%, and the pH value of a 10% (w / v) aqueous solution at the temperature of 25 + / -2 DEG C is 13.5-14.0; the slow-release agent can effectively regulate the acid-base balance of animals, improve the barrier function of intestinal mucosa of the animals and improve the appetite and digestion and absorption capacity of the animals, as shown in the embodiment, after the slow-release agent is applied to beef cattle in the fattening period, the average daily gain is increased by 20%, and the feed conversion rate is reduced by 15.8%; the goose gout prevention morbidity is reduced to 1%, the initial treatment cure rate reaches 96.7%, and the breeding economic benefits are remarkably improved.

The invention relates to the technical field of blood gas acid-base equilibrium analysis, and provides an intelligent blood gas analysis system which comprises an information acquisition module. The data verification module is configured to verify the accuracy of each blood gas index parameter; the data analysis module is configured to analyze the pulmonary alveolar ventilation function state of the patient and analyze the oxygenation state of the patient according to each blood gas index parameter; the acid-base balance analysis module is configured to judge the overall acid-base state of the blood according to the blood gas index parameters; the balance disorder analysis module is configured to determine the reason and the type of the acid-base imbalance caused by the acid-base imbalance according to each blood-gas index parameter; the acid-base imbalance judgment module is configured to calculate the compensation reasonability according to the reason and the type of the acid-base imbalance; and a result output module. According to the invention, multiple modules are arranged to cooperate with each other, so that data acquisition comprehensiveness and inspection and calculation standardization can be realized, and comprehensiveness and accuracy of analysis results can be guaranteed.

The invention discloses a method for determining influence of oleic acid with different concentrations and fermentation time on phellinus igniarius liquid fermentation, and relates to the technical field related to phellinus igniarius liquid fermentation. S1, preparing experimental materials, reagents and drugs; s2, a research method: S2-1, strain activation and strain liquid preparation; s2-2, fermenting phellinus igniarius mycelium liquid under different concentrations of oleic acid; s2-3, determining the biomass of the mycelium; s2-4, determining the pH value and acidity of the fermentation liquid; s2-5, preparing a phellinus igniarius mycelium extracting solution; s2-6, determining the antioxidant activity of the phellinus igniarius mycelium; s3, data analysis processing; and S4, obtaining a result and analyzing. According to the method for determining the influence of different concentrations of oleic acid and fermentation time on the fermentation of the phellinus igniarius liquid, different concentrations of oleic acid have influence on the growth of phellinus igniarius mycelium and the synthesis of active ingredient substances; the proper oleic acid can effectively maintain the acid-base balance of the phellinus igniarius growth environment, so that proper conditions are provided for the growth and metabolism of mycelia of the phellinus igniarius.

The application relates to a magnesium-cerium-gallic acid metal organic framework and preparation and application thereof, and the metal organic framework material is prepared by the following method: (1) dissolving a soluble cerium salt and a soluble magnesium salt in water, then adding gallic acid, and stirring to form a milky white colloidal solution; (2) adjusting the pH of the milky white colloidal solution obtained in step (1) to make it change from a milky white suspension to a dark brown solution; (3) transferring the obtained dark brown solution into a reaction kettle, heating and reacting, and then separating, washing and drying the obtained reaction product to obtain the target product, a magnesium-cerium-gallic acid metal organic framework. 2+ Adjusting an immune microenvironment and accelerating tissue regeneration.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and / or treating renal anemia, a preparation, a preparation method and application. The invention provides a traditional Chinese medicine composition for preventing and / or treating renal anemia, which is prepared from the following ingredients in parts by mass: 10 to 30 parts of turtle shells, 10 to 30 parts of radix astragali seu hedysari, 10 to 40 parts of seaweed, 15 to 30 parts of raw oyster shells, 2 to 5 parts of leeches, 5 to 15 parts of radix angelicae sinensis, 10 to 30 parts of rhizoma chuanxiong and 5 to 20 parts of abelmoschus manihot flowers. The embodiment shows that the turtle shell anti-aging liquid has the effect of improving the hemoglobin level, the red blood cell number and the renal function of a patient, the curative effect of the turtle shell anti-aging liquid is obviously superior to that of a nephritis anti-aging liquid formula and a Chinese patent medicine abelmoschus esculentus capsule, the turtle shell anti-aging liquid does not have obvious damage to the liver function, is high in safety, has the advantage of adjusting imbalance of electrolyte and acid-base balance level, and can be used for treating nephritis. The traditional Chinese medicine composition can delay renal tissue fibrosis and apoptosis and regulate renal anemia related pathways, is lower in cost, and can effectively relieve renal anemia and delay the progress of chronic kidney diseases.

The invention discloses a traditional Chinese medicine prescription for treating gout and promoting uric acid metabolism and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine prescriptions for gout, the traditional Chinese medicine prescription is prepared from the following raw materials in parts by weight: 1 part of chicory root (extract), 1 part of semen plantaginis, 1 part of dandelion, 1 part of sargentgloryvine stem, 1 part of sunflower disc alkaloid, 1 part of parasitic loranthus and 1 part of rhizoma smilacis glabrae. The preparation method comprises the step of grinding the chicory root (extract), the semen plantaginis, the dandelion, the sargentgloryvine stem, the sunflower disc alkaloid, the loranthus parasiticus and the dry leaves and branches of the rhizoma smilacis glabrae into powder to obtain the product. Before taking, the medicinal material powder is brewed with water at 70-80 DEG C. The formula can treat gout and promote uric acid metabolism in the body. As an orally taken prescription for soaking in water, the traditional Chinese medicine composition has the effects of (1) reducing swelling and removing stasis, inducing diuresis, promoting diuresis, treating stranguria, dispelling wind and relieving pain, ventilating, dredging collaterals and activating blood, clearing liver and benefiting gallbladder, tonifying liver and kidney, strengthening muscles and bones, protecting cardiovascular system, invigorating stomach and promoting digestion, expelling toxin, reducing blood pressure, blood fat, blood sugar and cholesterol, expanding coronary vessels, resisting inflammation and enhancing immunity; (2) gouty stones can be dissolved, and uric acid metabolism in the body can be accelerated; and (3) relieving mild acute gouty arthritis, namely reducing uric acid, dissolving calculus and regulating the acid-base balance degree of the body by the sunflower alkali to improve the symptoms such as uric acid level increase and gouty arthritis caused by purine metabolism disorder, neutralizing the uric acid, maintaining the acid-base balance in the body, reducing the attack frequency of gout and the like.

The present application relates to sunflower disc related raw material technical field, concretely relates to a kind of sunflower disc liposome and its application in preparation reduce uric acid and dissolve gout stone product.The sunflower disc liposome is formed by self-assembly with ferrocene sunflower disc peptide, alkaloid and flavone as raw material, can reduce uric acid, dissolve gout stone, balance in vivo acid-base balance, inhibit xanthine oxidase synthesis uric acid, promote in vivo uric acid excretion and intestinal peristalsis, repair damaged liver and kidney cells, swelling anti-inflammatory analgesic, prevent and treat hyperuricemia, relieve gout inflammation, reduce blood pressure, improve immunity.

The invention discloses a human body lubricating liquid which comprises propylene glycol, glycerol, sodium hyaluronate, carbomer, arginine, silver ions and a pH regulator, and betaine or coumarin is selectively added. Wherein the propylene glycol and the glycerol synergistically provide long-acting moisture retention, the sodium hyaluronate enhances lubrication and smoothness and repairs skin barriers, the carbomer adjusts viscosity and stability, the arginine relieves inflammation and maintains acid-base balance, the silver ions inhibit pathogenic microorganisms through broad-spectrum antibacterial characteristics, and the pH regulator enables the product to be close to the physiological pH value of a human body. Betaine and coumarin can be used in an alternative manner or have a synergistic effect, and the skin protection capability is improved by resisting inflammation and oxidation and inhibiting free radicals respectively. The human body lubricating liquid disclosed by the invention has remarkable advantages in the aspects of lubricating effect, moisturizing performance, antibacterial ability, use comfort and the like.