A CFD-based optimization method for a fermenter for
amino acid fermentation according to an embodiment of the present invention includes: a first step of setting an objective variable, a constraint variable, and a design variable with respect to an optimization objective of at least one
impeller fermenter; a second step of generating a three-dimensional shape for a flow region of the
impeller fermenter for each condition of the constraint variable and the design variable according to the objective variable; a third step of calculating a primary value, which is at least one of
oxygen diffusion coefficient,
liquid density,
liquid viscosity, gas hold-up, bubble
diameter, energy dissipation rate, and torque, by computational fluid dynamics analysis for the flow region based on information about the three-dimensional shape; a fourth step of calculating secondary values, which are an
oxygen transfer coefficient and a
power consumption ratio (
power ratio), using the primary value; and a fifth step of repeating the second, third, and fourth steps while varying the design variable of the first step in various ways, and finding an optimal point based on a comparison value obtained by comparing the secondary values before and after the variation.