6 results about "Polypyridine complex" patented technology

The invention relates to the technical field of DNA intercalating agents, in particular to a near-infrared luminous ruthenium (II) complex, a preparation method thereof and application of the complex as a DNA intercalating agent. The preparation method comprises the following steps: firstly, preparing a precursor 4 '-(1H-benzimidazole-2-yl)-2, 2': 6 ', 2' '-terpyridyl; then, preparing a target precursor, namely, 2-(4-(anthracene-10-yl)-6-(pyrazine-2-yl) pyridine-2-yl) pyrazine as a ligand; and finally, synthesizing a complex [Ru (An-di (2-Pz) Py) (Bitpy)]. The complex is inserted into a DNA base pair as an intercalating agent, has very strong interaction with DNA, and provides basic research for researching the interaction mode of the ruthenium (II) polypyridine complex of the tridentate ligand and DNA and taking the ruthenium (II) polypyridine complex as a diagnosis and treatment reagent.

The present invention discloses a metal ruthenium complex with a binuclear structure for resisting drug-resistant bacteria, a preparation method and an application thereof, and relates to the field of antibacterial medicine technology. The structure of the complex is as follows:, which can be used to prepare drugs for resisting drug-resistant bacteria, reducing hemolysis of red blood cells, inhibiting MRSA and / or inhibiting the formation of MRSA biofilms. Since the complex contains metal ions and carries four positive charges, compared with traditional organic small molecules, it enhances its ability to penetrate bacterial cell membranes and retention effect, and the multi-coordinate configuration of the metal complex allows it to be modified with different ligands, thereby making it more biologically active. Experiments have shown that the bis-ruthenium polypyridine complex of the present invention can effectively reduce the hemolytic effect of toxins released by MRSA on red blood cells, and can inhibit the formation of MRSA biofilms.

The invention discloses a ruthenium polypyridine complex with a sulfonyl fluoride skeleton structure as well as a preparation method and application of the ruthenium polypyridine complex, and belongs to the technical field of antibacterial medicines. According to the ruthenium polypyridine complex with the sulfonyl fluoride structure, ligands obtained after the ruthenium polypyridine complex is coordinated with bipyridines with different substituent groups all carry positive charges and can be combined with negative ions on the surfaces of bacterial cell membranes to damage the bacterial cell membranes, so that bacterial growth is inhibited, and finally bacteria are killed; the introduction of a sulfonyl fluoride structure, a carbon chain structure, an aromatic ring structure and an aromatic heterocyclic structure effectively enhances the biological activity of the complex and the destructive effect on a cell membrane, and bacteria are not easy to secrete alpha-toxin.

The present invention relates to the field of metal complexes, and in particular to a ruthenium polypyridine complex, a preparation method thereof, and anti-tumor applications. The absorption wavelength of the ruthenium polypyridine complex can be extended to 750 nm, and singlet oxygen can be generated under illumination conditions. The singlet oxygen quantum yield thereof in acetonitrile solution was measured to be 0.54. Compared with the chemotherapy drug cisplatin, the ruthenium polypyridine complex exhibits stronger cytotoxicity, and its toxicity to tumor cells after illumination is greater than that under dark conditions, and has the potential for photodynamic therapy (PDT). The content of the present invention has good clinical application prospects and can be used to further prepare photodynamic anti-tumor drugs.

The invention relates to the field of metal complexes, in particular to a ruthenium polypyridine complex with multiple phototherapy mechanisms as well as a preparation method and anti-lung cancer application of the ruthenium polypyridine complex. The absorption wavelength of the ruthenium polypyridine complex is prolonged to 700nm, and the ruthenium polypyridine complex has good light and dark stability. The complex not only can efficiently generate singlet oxygen after light activation, but also can effectively destroy NADH / NAD < + > redox balance, and shows PDT and photocatalytic cancer treatment dual activities. The complex has relatively low dark toxicity and extremely strong phototoxicity to non-small cell lung cancer cells A549, and after light activation, cell apoptosis can be induced, so that A549 cell death can be caused. The content of the invention is expected to bring new breakthrough to lung cancer treatment.

This invention belongs to the field of antibacterial pharmaceutical technology, and discloses a pyrrole-modified iridium polypyridine complex for antibacterial purposes, its preparation method, and its applications. In the compound structure of the pyrrole-modified iridium polypyridine complex, pyrrole is a penta-nitrogen heterocycle with significant research value. Combined with the metallic element iridium, compared to traditional small organic molecules, it enhances its ability to penetrate bacterial cell membranes, improves transmembrane activity, and effectively penetrates into the bacterial cell membrane, generating ROS-induced oxidative stress, thereby leading to bacterial death. Experiments have demonstrated that the complex of this invention can produce ROS-induced oxidative stress and inhibit biofilm formation.