30 results about "Polypyridine complex" patented technology

The invention discloses a ruthenium polypyridine complex and a preparation method and application of [Ru(L)2(tppp)]<2+> thereof. 2, 2'-bipyridine and 1,10'-phenanthroline are used as auxiliary ligands, and tppp is used as a main ligand (tppp=12-(2-thienyl)-pyrido[2', 3':5, 6]pyrazino[2,3-f][1,10]phenanthroline. The ruthenium complex disclosed by the invention has a recognition function, a combination function and a stabilization function on a telomere G-quadruplex. According to TO competition, the combining capacity between the complex and the G-quadruplex is stronger than that of double-stranded DNA, indicating that the complex has a recognition function; according to a TO competition experiment and a DNA melting temperature measurement experiment, the combining capacity and stabilizing capacity of the ruthenium complex a2 on the G-quadruplex are obviously stronger than those of a1.

The invention discloses a synthesis method and application of an anthraquinone polypyridine ligand and anthraquinone-ruthenium polypyridine complex. The anthraquinone-ruthenium polypyridine complex has good inhibition activity on the growth of hypoxic cells, and generates obvious fluorescence through reduction in the hypoxic cells; and thus, the compound is a novel biological reduction type hypoxic cell anti-cancer drug and a specific fluorescence probe as well as a drug with application value and taking tumor hypoxia as a target point and a fluorescence probe.

Cobalt polypyridine complexes are interesting alternative redox mediators for large scale manufacturing of dye-sensitized solar cells (DSCs) since they are less aggressive towards metal contacts and absorb less light than iodide / triiodide. Here we have examined the effect of steric properties of triphenylamine-based organic sensitizers and cobalt polypyridine redox mediators on the electron lifetime and overall device performance in DSCs. Matching the steric bulk of the dye and redox mediator was found to minimize recombination and mass transport problems in DSCs employing cobalt redox mediators. Recombination was efficiently slowed down by introducing insulating butoxyl chains on the dye, allowing the use of a cobalt redox mediator with a less steric bulk. The best efficiency of DSCs sensitized with a triphenylamine-based organic dye in combination with cobalt(II / III) tris(2,2'-bipyridyl) match the highest efficiencies obtained so far with iodide-free electrolytes, reaching a 6.3 % overall conversion efficiency under AMI.5 condition (1000 Wm-2) and an efficiency of 7.8 % at 1 / 10 of a sun. Organic dyes with high extinction coefficients can thus be used instead of standard ruthenium sensitizers to build thin films DSCs in order to overcome mass transport and recombination limitations associated with the cobalt redox couples. DSCs sensitized with organic dyes employing cobalt redox mediators are promising for low light intensity applications since the efficiency and voltage is high at indoor illumination.

The invention discloses a simple preparation method of an electrochemiluminescent reagent ruthenium polypyridine complex. The preparation method comprises the following steps: dissolving a ruthenium chloride hydrate and 2, 2'-dipyridyl in a mixed solvent of ethanol and ethylene glycol, wherein the ratio of ruthenium trichloride in the ruthenium chloride hydrate to 2, 2'-dipyridylis 1:4-1:5, and the concentration of ruthenium trichloride in the mixed solvent is 0.02-0.025mol / L; heating to react, wherein the reaction temperature is 70-100 DEG C and the reaction time is 6-10 hours; cooling to room temperature and carrying out rotary evaporation to remove ethanol; adding a saturated sodium chloride solution to separate out solids, filtering, adding water to recrystallize and drying to obtain tri(2, 2'-dipyridyl) ruthenium chloride (II) hexahydrate. The synthetic method is simple and convenient, short in reaction step, easy to operate, less in consumption of organic solvents, simple in post-treatment and high in product purity. The conversation ratio of noble metal ruthenium reaches up to 95%, so that the preparation method is less in environmental protection pressure and convenient for industrialized production.

The invention discloses a synthesis method and application of an anthraquinone polypyridine ligand and anthraquinone-ruthenium polypyridine complex. The anthraquinone-ruthenium polypyridine complex has good inhibition activity on the growth of hypoxic cells, and generates obvious fluorescence through reduction in the hypoxic cells; and thus, the compound is a novel biological reduction type hypoxic cell anti-cancer drug and a specific fluorescence probe as well as a drug with application value and taking tumor hypoxia as a target point and a fluorescence probe.

The invention relates to ruthenium (II) polypyridine complex.The complex uses 2-(1, 10-phenanthroline monohydrate-5-base)-benzimidazole) as the main ligand and 2, 2'-bipyridine or 1, 10'-phenanthroline as the auxiliary ligand, and the chemical formula of the complex is [Ru(bpy)2pbi]2+ or [Ru(phen)2pbi]2+.A preparation method of the complex includes the steps of firstly, preparing pbi; secondly, synthesizing a ruthenium metal compound with the auxiliary ligand group; thirdly, synthesizing the target ruthenium (II) polypyridine complex; fourthly, using silica gel chromatography column separation to obtain the product.The ruthenium (II) polypyridine complex is used for preparing medicine combining with telomere G-quadruplex to increase the stability of the telomere G-quadruplex.Compared with the prior art, the ruthenium (II) polypyridine complex prepared by the method has the advantages that the ruthenium (II) polypyridine complex can recognize, combine and stabilize the telomere G-quadruplex, inhibit telomerase activity and regulate proto-oncogene expression, and a theoretical foundation is provided for anticancer medicine screening.

The present invention is based on [Ru(bpy) 3 ] 2+ Ru(II) complexes with different conjugation systems were synthesized by modifying the ligands of the polypyridine ruthenium complexes as the core, and the ligand conjugation structure was studied for the generation of singlet oxygen in such complexes. rate impact. In the photodynamic therapy of tumors, the complexes of the present invention have the maximum singlet oxygen production rate, and not only have higher phototoxicity under light, but also increase the uptake of the complexes by cells. The increase in the amount leads to the possible chemical anti-cancer effect after it enters the cells, further improving its anti-tumor activity.

The invention discloses a liposome-encapsulated ruthenium polypyridine complex and its application. By using dichlorobis(2,2'-bipyridine) ruthenium and ruthenium acetate as anticancer metal complexes, compared with cis Platinum and ruthenium complexes have low toxicity and side effects, are easy to absorb and excrete quickly, and can inhibit tumor growth and metastasis; at the same time, they are encapsulated with liposomes, and by adding blending agents, antioxidants, buffers, antibacterial agents and stabilizers , wherein the blending agent has selected bis(triethanolamine) diisopropyl titanate, trimethoxy[2-(7-oxabicyclo[4.1.0]heptyl-3-yl)ethyl]silane, (3S, 6E,10S)‑6,10‑dimethyl‑3‑isopropylcyclodec‑6‑ene‑1,4‑dione and diethylene glycol ether, under the combined action of these substances, can greatly improve The mutual coordination between liposomes and ruthenium complexes makes the final liposome-encapsulated ruthenium polypyridine complexes have good biocompatibility and low toxicity; It can be used as a chemotherapeutic or imaging agent in treatment.

The invention relates to a melamine fluorescence spectrum detection method based on metallic ruthenium polypyridine complex. Melamine and DNA rich in thymine can form the effect of three special hydrogen bonds, so that the DNA can be transformed into three strands from a single strand, and as (Ru(phen)2dppz-idzo)<2+> (phen is 1,10-phenanthroline, dppz is bispyridine phenazine, and idzo is imidazolone) has strong insertion effect on three-strand DNA, fluorescence enhanced range of the three-strand DNA is obviously higher than that of single-strand DNA. When the concentration of the melamine is 0 to 7.0 micro mol / L, the concentration of the obviously and a fluorescence response value have a good linear relation, linear regression equations are respectively F=199.96+85.41c (C: micro mol / L), and a linear coefficient R2 is 0.9923. Meanwhile, by adding melamine with different concentrations to pure milk samples through a constructed method, a satisfactory recovery rate is obtained.

A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and / or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

The invention discloses a ruthenium polypyridine complex, the structure of the ruthenium polypyridine complex is shown as a formula 1, the ruthenium polypyridine complex is used as a photoacid generator, and the problems that the existing photoacid generator needs to be irradiated by ultraviolet light to generate acid, the acid generation reaction time is long, the dosage of required raw materialsis large and the efficiency is low can be solved. The invention also discloses a preparation method and application of the ruthenium polypyridine complex.

The invention discloses an iridium-selenium polypyridine complex as well as a preparation method and an application of the iridium-selenium polypyridine complex. The iridium-selenium polypyridine complex disclosed by the invention has the chemical formula of [Ir (N-C)2(phenSe)]+(N-C=ppy, dfppy, btp, 2-pq or dbq), is derived from selenium-5, 6-diamine-1, 10-ortho phenanthroline, has a good living cell mitochondria coloring characteristic, a strong cell membrane penetration capacity and low cytotoxicity and has a great application potential in the aspects of biolabeling and cell imaging.

The present invention is concerned with a staining dye for staining a biological cell, comprising dye molecules with a positively charged polar head group for attraction to cell membrane of the cell and for refraining the dye molecules from entering the cytoplasm, and one or more hydrophobic groups for interaction with phospholipids of the cell membrane. The dye molecules are phosphorescent transition metal polypyridine complexes having a metal center and ligands which are non-organic fluorophores.

The invention discloses a simple preparation method of an electrochemiluminescent reagent ruthenium polypyridine complex. The preparation method comprises the following steps: dissolving a ruthenium chloride hydrate and 2, 2'-dipyridyl in a mixed solvent of ethanol and ethylene glycol, wherein the ratio of ruthenium trichloride in the ruthenium chloride hydrate to 2, 2'-dipyridylis 1:4-1:5, and the concentration of ruthenium trichloride in the mixed solvent is 0.02-0.025mol / L; heating to react, wherein the reaction temperature is 70-100 DEG C and the reaction time is 6-10 hours; cooling to room temperature and carrying out rotary evaporation to remove ethanol; adding a saturated sodium chloride solution to separate out solids, filtering, adding water to recrystallize and drying to obtain tri(2, 2'-dipyridyl) ruthenium chloride (II) hexahydrate. The synthetic method is simple and convenient, short in reaction step, easy to operate, less in consumption of organic solvents, simple in post-treatment and high in product purity. The conversation ratio of noble metal ruthenium reaches up to 95%, so that the preparation method is less in environmental protection pressure and convenient for industrialized production.

The invention discloses a synthesis method of ginkgo biloba polyprenol metal complex with light control activity. The method comprises the following steps: using high-purity ginkgo biloba polyprenol as a raw material, replacing the terminal hydroxyl group of the polyprenol with an active group with stronger coordination ability by means of chemical modification, and then combining it with a ruthenium polypyridine complex Carry out complexation reaction to synthesize Ginkgo biloba polyprenol-ruthenium polypyridine metal complex; the prepared complex has good photodissociation efficiency and light-controlled anti-tumor properties, and can be used as a high-value Ginkgo biloba polyprene Provide theoretical reference and technical support for the development of alcohol functional products.

The invention provides a ruthenium (II)-polypyridine complex. For the ruthenium (II)-polypyridine complex, bipyridyl (bpy) or phenanthroline hydrate (phen) is used as an ancillary ligand, and dipyridine[3,2-a:2',3'-c]phenazine-11,12-imidazole (dppzi) is used as a main ligand. The preparation method comprises the following steps: preparing 5,6-dinitrobenzimidazole from 5,6-nitrobenzimidazole; reducing 5,6-dinitrobenzimidazole into 5,6-diaminobenzimidazole by using hydrazine hydrate and palladium / carbon; preparing dppzi from phenanthroline hydrate-5,6-dione and 5,6-diaminobenzimidazole and preparing cis-[Ru(bpy)2Cl2].2H2O from ruthenium trichloride, bpy and lithium chloride; preparing cis-[Ru(phen)2Cl2].3H2O from ruthenium trichloride, phen and lithium chloride; carrying out a heating reflux reaction on dppzi and cis-[Ru(bpy)2Cl2].2H2O or cis-[Ru(phen)2Cl2].3H2O under the protection of argon, carrying out cooling, adding ammonium hexafluorophosphate, allowing precipitate to deposit and carrying out filtration and column chromatography so as to obtain a target product. The ruthenium (II)-polypyridine complex provided in the invention can be used as an optical switch for G-quadruplex DNA molecules.