The invention relates to the technical field of purification of protein polypeptide in peanut meal, in particular to purification equipment for protein polypeptide in peanut meal. The peanut meal is pretreated through a grinding box, condensed peanut meal is dispersed through a material dispersing mechanism, the peanut meal is ground into fine particles through a grinding mechanism, subsequent peanut meal and a solution are effectively mixed and react thoroughly, the extraction amount of the protein peptide is guaranteed, waste of peanut meal raw material is reduced, and the conversion rate isincreased; a turbine and a worm are matched to drive a reaction box to rotate, the reaction box drives the internal solution and the peanut meal to rotate and mix, and a mixing mechanism continuouslystirs the solution and the peanut meal, so that the mixing speed and the mixing uniformity are improved, the reaction time is shortened, and the mixing efficiency and the processing efficiency are improved; and a premixing box premixes the solution and peanut meal, a preheating layer preliminarily heats the solution and the peanut meal, the reaction speed is increased, the mixing time in the reaction box in the later period is shortened, and a solution box is arranged at the rear end of the grinding box, so that the interior of the premixing box is convenient to clean.